Rational Design and Synthesis of New Selective COX-2 Inhibitors with In Vivo PGE2-Lowering Activity by Tethering Benzenesulfonamide and 1,2,3-Triazole Pharmacophores to Some NSAIDs

New selective COX-2 inhibitors were designed and synthesized by tethering 1,2,3-triazole and benzenesulfonamide pharmacophores to some NSAIDs. Compounds 6b and 6j showed higher in vitro COX-2 selectivity and inhibitory activity (IC(50) = 0.04 µM and S.I. = 329 and 312, respectively) than celecoxib (...

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Detalles Bibliográficos
Autores principales: El-Dershaby, Nada H., El-Hawash, Soad A., Kassab, Shaymaa E., Daabees, Hoda G., Abdel Moneim, Ahmed E., El-Miligy, Mostafa M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609428/
https://www.ncbi.nlm.nih.gov/pubmed/36297278
http://dx.doi.org/10.3390/ph15101165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609428/
https://www.ncbi.nlm.nih.gov/pubmed/36297278
http://dx.doi.org/10.3390/ph15101165

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