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Viral Infection Profile in Children Treated for Acute Lymphoblastic Leukemia—Results of Nationwide Study

Viral infections can be a serious complication of therapy in children with acute lymphoblastic leukemia (ALL). In this study, we focused on the incidence and the profile of viral infection in children with ALL treated in 17 pediatric oncology centers in Poland in the two-year periods of 2018–2019 an...

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Autores principales: Zawitkowska, Joanna, Drabko, Katarzyna, Czyżewski, Krzysztof, Dziedzic, Magdalena, Jaremek, Kamila, Zalas-Więcek, Patrycja, Szmydki-Baran, Anna, Hutnik, Łukasz, Matysiak, Michał, Czogała, Wojciech, Balwierz, Walentyna, Żak, Iwona, Salamonowicz-Bodzioch, Małgorzata, Kazanowska, Bernarda, Wróbel, Grażyna, Kałwak, Krzysztof, Tomaszewska, Renata, Szczepański, Tomasz, Zając-Spychała, Olga, Wachowiak, Jacek, Płonowski, Marcin, Krawczuk-Rybak, Maryna, Królak, Aleksandra, Ociepa, Tomasz, Urasiński, Tomasz, Pierlejewski, Filip, Młynarski, Wojciech, Urbańska-Rakus, Justyna, Machnik, Katarzyna, Pająk, Sonia, Badowska, Wanda, Brzeski, Tomasz, Mycko, Katarzyna, Mańko-Glińska, Hanna, Urbanek-Dądela, Agnieszka, Karolczyk, Grażyna, Mizia-Malarz, Agnieszka, Stolpa, Weronika, Skowron-Kandzia, Katarzyna, Musiał, Jakub, Chaber, Radosław, Irga-Jaworska, Ninela, Bień, Ewa, Styczyński, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609456/
https://www.ncbi.nlm.nih.gov/pubmed/36297147
http://dx.doi.org/10.3390/pathogens11101091
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author Zawitkowska, Joanna
Drabko, Katarzyna
Czyżewski, Krzysztof
Dziedzic, Magdalena
Jaremek, Kamila
Zalas-Więcek, Patrycja
Szmydki-Baran, Anna
Hutnik, Łukasz
Matysiak, Michał
Czogała, Wojciech
Balwierz, Walentyna
Żak, Iwona
Salamonowicz-Bodzioch, Małgorzata
Kazanowska, Bernarda
Wróbel, Grażyna
Kałwak, Krzysztof
Tomaszewska, Renata
Szczepański, Tomasz
Zając-Spychała, Olga
Wachowiak, Jacek
Płonowski, Marcin
Krawczuk-Rybak, Maryna
Królak, Aleksandra
Ociepa, Tomasz
Urasiński, Tomasz
Pierlejewski, Filip
Młynarski, Wojciech
Urbańska-Rakus, Justyna
Machnik, Katarzyna
Pająk, Sonia
Badowska, Wanda
Brzeski, Tomasz
Mycko, Katarzyna
Mańko-Glińska, Hanna
Urbanek-Dądela, Agnieszka
Karolczyk, Grażyna
Mizia-Malarz, Agnieszka
Stolpa, Weronika
Skowron-Kandzia, Katarzyna
Musiał, Jakub
Chaber, Radosław
Irga-Jaworska, Ninela
Bień, Ewa
Styczyński, Jan
author_facet Zawitkowska, Joanna
Drabko, Katarzyna
Czyżewski, Krzysztof
Dziedzic, Magdalena
Jaremek, Kamila
Zalas-Więcek, Patrycja
Szmydki-Baran, Anna
Hutnik, Łukasz
Matysiak, Michał
Czogała, Wojciech
Balwierz, Walentyna
Żak, Iwona
Salamonowicz-Bodzioch, Małgorzata
Kazanowska, Bernarda
Wróbel, Grażyna
Kałwak, Krzysztof
Tomaszewska, Renata
Szczepański, Tomasz
Zając-Spychała, Olga
Wachowiak, Jacek
Płonowski, Marcin
Krawczuk-Rybak, Maryna
Królak, Aleksandra
Ociepa, Tomasz
Urasiński, Tomasz
Pierlejewski, Filip
Młynarski, Wojciech
Urbańska-Rakus, Justyna
Machnik, Katarzyna
Pająk, Sonia
Badowska, Wanda
Brzeski, Tomasz
Mycko, Katarzyna
Mańko-Glińska, Hanna
Urbanek-Dądela, Agnieszka
Karolczyk, Grażyna
Mizia-Malarz, Agnieszka
Stolpa, Weronika
Skowron-Kandzia, Katarzyna
Musiał, Jakub
Chaber, Radosław
Irga-Jaworska, Ninela
Bień, Ewa
Styczyński, Jan
author_sort Zawitkowska, Joanna
collection PubMed
description Viral infections can be a serious complication of therapy in children with acute lymphoblastic leukemia (ALL). In this study, we focused on the incidence and the profile of viral infection in children with ALL treated in 17 pediatric oncology centers in Poland in the two-year periods of 2018–2019 and 2020–2021. We also compared the frequency of viral infections in 2018–2019 to that in 2020–2021. In 2020–2021, a total of 192 children with ALL had a viral infection during intensive chemotherapy. A total number of 312 episodes of viral infections were diagnosed. The most common infections detected in the samples were: COVID-19 (23%), rhinovirus (18%), and respiratory syncytial virus (14%). COVID-19 and BK virus infections were the reason for the death 1% of all patients. In 2018–2019, a total of 53 ALL patients who had a viral infection were reported and 72 viral events were observed, mainly adenovirus (48.6%), rotavirus (31.9%), and herpes zoster (8.3%). No deaths were reported during this period. The cumulative incidence of viral infections in 2018–2019 was 10.4%, while for 2020–2021, it was 36.7%. In conclusion, a high incidence of COVID-19 infection was observed among pediatric patients with ALL in Poland. The mortality rate in our material was low. The viral profile in ALL children undergoing chemotherapy can be useful for clinicians to improve prophylactic and therapeutic strategies.
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spelling pubmed-96094562022-10-28 Viral Infection Profile in Children Treated for Acute Lymphoblastic Leukemia—Results of Nationwide Study Zawitkowska, Joanna Drabko, Katarzyna Czyżewski, Krzysztof Dziedzic, Magdalena Jaremek, Kamila Zalas-Więcek, Patrycja Szmydki-Baran, Anna Hutnik, Łukasz Matysiak, Michał Czogała, Wojciech Balwierz, Walentyna Żak, Iwona Salamonowicz-Bodzioch, Małgorzata Kazanowska, Bernarda Wróbel, Grażyna Kałwak, Krzysztof Tomaszewska, Renata Szczepański, Tomasz Zając-Spychała, Olga Wachowiak, Jacek Płonowski, Marcin Krawczuk-Rybak, Maryna Królak, Aleksandra Ociepa, Tomasz Urasiński, Tomasz Pierlejewski, Filip Młynarski, Wojciech Urbańska-Rakus, Justyna Machnik, Katarzyna Pająk, Sonia Badowska, Wanda Brzeski, Tomasz Mycko, Katarzyna Mańko-Glińska, Hanna Urbanek-Dądela, Agnieszka Karolczyk, Grażyna Mizia-Malarz, Agnieszka Stolpa, Weronika Skowron-Kandzia, Katarzyna Musiał, Jakub Chaber, Radosław Irga-Jaworska, Ninela Bień, Ewa Styczyński, Jan Pathogens Article Viral infections can be a serious complication of therapy in children with acute lymphoblastic leukemia (ALL). In this study, we focused on the incidence and the profile of viral infection in children with ALL treated in 17 pediatric oncology centers in Poland in the two-year periods of 2018–2019 and 2020–2021. We also compared the frequency of viral infections in 2018–2019 to that in 2020–2021. In 2020–2021, a total of 192 children with ALL had a viral infection during intensive chemotherapy. A total number of 312 episodes of viral infections were diagnosed. The most common infections detected in the samples were: COVID-19 (23%), rhinovirus (18%), and respiratory syncytial virus (14%). COVID-19 and BK virus infections were the reason for the death 1% of all patients. In 2018–2019, a total of 53 ALL patients who had a viral infection were reported and 72 viral events were observed, mainly adenovirus (48.6%), rotavirus (31.9%), and herpes zoster (8.3%). No deaths were reported during this period. The cumulative incidence of viral infections in 2018–2019 was 10.4%, while for 2020–2021, it was 36.7%. In conclusion, a high incidence of COVID-19 infection was observed among pediatric patients with ALL in Poland. The mortality rate in our material was low. The viral profile in ALL children undergoing chemotherapy can be useful for clinicians to improve prophylactic and therapeutic strategies. MDPI 2022-09-24 /pmc/articles/PMC9609456/ /pubmed/36297147 http://dx.doi.org/10.3390/pathogens11101091 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zawitkowska, Joanna
Drabko, Katarzyna
Czyżewski, Krzysztof
Dziedzic, Magdalena
Jaremek, Kamila
Zalas-Więcek, Patrycja
Szmydki-Baran, Anna
Hutnik, Łukasz
Matysiak, Michał
Czogała, Wojciech
Balwierz, Walentyna
Żak, Iwona
Salamonowicz-Bodzioch, Małgorzata
Kazanowska, Bernarda
Wróbel, Grażyna
Kałwak, Krzysztof
Tomaszewska, Renata
Szczepański, Tomasz
Zając-Spychała, Olga
Wachowiak, Jacek
Płonowski, Marcin
Krawczuk-Rybak, Maryna
Królak, Aleksandra
Ociepa, Tomasz
Urasiński, Tomasz
Pierlejewski, Filip
Młynarski, Wojciech
Urbańska-Rakus, Justyna
Machnik, Katarzyna
Pająk, Sonia
Badowska, Wanda
Brzeski, Tomasz
Mycko, Katarzyna
Mańko-Glińska, Hanna
Urbanek-Dądela, Agnieszka
Karolczyk, Grażyna
Mizia-Malarz, Agnieszka
Stolpa, Weronika
Skowron-Kandzia, Katarzyna
Musiał, Jakub
Chaber, Radosław
Irga-Jaworska, Ninela
Bień, Ewa
Styczyński, Jan
Viral Infection Profile in Children Treated for Acute Lymphoblastic Leukemia—Results of Nationwide Study
title Viral Infection Profile in Children Treated for Acute Lymphoblastic Leukemia—Results of Nationwide Study
title_full Viral Infection Profile in Children Treated for Acute Lymphoblastic Leukemia—Results of Nationwide Study
title_fullStr Viral Infection Profile in Children Treated for Acute Lymphoblastic Leukemia—Results of Nationwide Study
title_full_unstemmed Viral Infection Profile in Children Treated for Acute Lymphoblastic Leukemia—Results of Nationwide Study
title_short Viral Infection Profile in Children Treated for Acute Lymphoblastic Leukemia—Results of Nationwide Study
title_sort viral infection profile in children treated for acute lymphoblastic leukemia—results of nationwide study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609456/
https://www.ncbi.nlm.nih.gov/pubmed/36297147
http://dx.doi.org/10.3390/pathogens11101091
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