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Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin
Application of nanocarriers for drug delivery brings numerous advantages, allowing both minimization of side effects common in systemic drug delivery and improvement in targeting, which has made it the focal point of nanoscience for a number of years. While most of the studies are focused on encapsu...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609473/ https://www.ncbi.nlm.nih.gov/pubmed/36295201 http://dx.doi.org/10.3390/ma15207136 |
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author | Artyukhov, Alexander A. Nechaeva, Anna M. Shtilman, Mikhail I. Chistyakov, Evgeniy M. Svistunova, Alina Yu. Bagrov, Dmitry V. Kuskov, Andrey N. Docea, Anca O. Tsatsakis, Aristides M. Gurevich, Leonid Mezhuev, Yaroslav O. |
author_facet | Artyukhov, Alexander A. Nechaeva, Anna M. Shtilman, Mikhail I. Chistyakov, Evgeniy M. Svistunova, Alina Yu. Bagrov, Dmitry V. Kuskov, Andrey N. Docea, Anca O. Tsatsakis, Aristides M. Gurevich, Leonid Mezhuev, Yaroslav O. |
author_sort | Artyukhov, Alexander A. |
collection | PubMed |
description | Application of nanocarriers for drug delivery brings numerous advantages, allowing both minimization of side effects common in systemic drug delivery and improvement in targeting, which has made it the focal point of nanoscience for a number of years. While most of the studies are focused on encapsulation of hydrophobic drugs, delivery of hydrophilic compounds is typically performed via covalent attachment, which often requires chemical modification of the drug and limits the release kinetics. In this paper, we report synthesis of biphilic copolymers of various compositions capable of self-assembly in water with the formation of nanoparticles and suitable for ionic binding of the common anticancer drug doxorubicin. The copolymers are synthesized by radical copolymerization of N-vinyl-2-pyrrolidone and acrylic acid using n-octadecyl-mercaptan as a chain transfer agent. With an increase of the carboxyl group’s share in the chain, the role of the electrostatic stabilization factor of the nanoparticles increased as well as the ability of doxorubicin as an ion binder. A mathematical description of the kinetics of doxorubicin binding and release is given and thermodynamic functions for the equilibrium ionic binding of doxorubicin are calculated. |
format | Online Article Text |
id | pubmed-9609473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96094732022-10-28 Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin Artyukhov, Alexander A. Nechaeva, Anna M. Shtilman, Mikhail I. Chistyakov, Evgeniy M. Svistunova, Alina Yu. Bagrov, Dmitry V. Kuskov, Andrey N. Docea, Anca O. Tsatsakis, Aristides M. Gurevich, Leonid Mezhuev, Yaroslav O. Materials (Basel) Article Application of nanocarriers for drug delivery brings numerous advantages, allowing both minimization of side effects common in systemic drug delivery and improvement in targeting, which has made it the focal point of nanoscience for a number of years. While most of the studies are focused on encapsulation of hydrophobic drugs, delivery of hydrophilic compounds is typically performed via covalent attachment, which often requires chemical modification of the drug and limits the release kinetics. In this paper, we report synthesis of biphilic copolymers of various compositions capable of self-assembly in water with the formation of nanoparticles and suitable for ionic binding of the common anticancer drug doxorubicin. The copolymers are synthesized by radical copolymerization of N-vinyl-2-pyrrolidone and acrylic acid using n-octadecyl-mercaptan as a chain transfer agent. With an increase of the carboxyl group’s share in the chain, the role of the electrostatic stabilization factor of the nanoparticles increased as well as the ability of doxorubicin as an ion binder. A mathematical description of the kinetics of doxorubicin binding and release is given and thermodynamic functions for the equilibrium ionic binding of doxorubicin are calculated. MDPI 2022-10-13 /pmc/articles/PMC9609473/ /pubmed/36295201 http://dx.doi.org/10.3390/ma15207136 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Artyukhov, Alexander A. Nechaeva, Anna M. Shtilman, Mikhail I. Chistyakov, Evgeniy M. Svistunova, Alina Yu. Bagrov, Dmitry V. Kuskov, Andrey N. Docea, Anca O. Tsatsakis, Aristides M. Gurevich, Leonid Mezhuev, Yaroslav O. Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin |
title | Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin |
title_full | Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin |
title_fullStr | Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin |
title_full_unstemmed | Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin |
title_short | Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin |
title_sort | nanoaggregates of biphilic carboxyl-containing copolymers as carriers for ionically bound doxorubicin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609473/ https://www.ncbi.nlm.nih.gov/pubmed/36295201 http://dx.doi.org/10.3390/ma15207136 |
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