Cargando…

Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin

Application of nanocarriers for drug delivery brings numerous advantages, allowing both minimization of side effects common in systemic drug delivery and improvement in targeting, which has made it the focal point of nanoscience for a number of years. While most of the studies are focused on encapsu...

Descripción completa

Detalles Bibliográficos
Autores principales: Artyukhov, Alexander A., Nechaeva, Anna M., Shtilman, Mikhail I., Chistyakov, Evgeniy M., Svistunova, Alina Yu., Bagrov, Dmitry V., Kuskov, Andrey N., Docea, Anca O., Tsatsakis, Aristides M., Gurevich, Leonid, Mezhuev, Yaroslav O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609473/
https://www.ncbi.nlm.nih.gov/pubmed/36295201
http://dx.doi.org/10.3390/ma15207136
_version_ 1784819028592689152
author Artyukhov, Alexander A.
Nechaeva, Anna M.
Shtilman, Mikhail I.
Chistyakov, Evgeniy M.
Svistunova, Alina Yu.
Bagrov, Dmitry V.
Kuskov, Andrey N.
Docea, Anca O.
Tsatsakis, Aristides M.
Gurevich, Leonid
Mezhuev, Yaroslav O.
author_facet Artyukhov, Alexander A.
Nechaeva, Anna M.
Shtilman, Mikhail I.
Chistyakov, Evgeniy M.
Svistunova, Alina Yu.
Bagrov, Dmitry V.
Kuskov, Andrey N.
Docea, Anca O.
Tsatsakis, Aristides M.
Gurevich, Leonid
Mezhuev, Yaroslav O.
author_sort Artyukhov, Alexander A.
collection PubMed
description Application of nanocarriers for drug delivery brings numerous advantages, allowing both minimization of side effects common in systemic drug delivery and improvement in targeting, which has made it the focal point of nanoscience for a number of years. While most of the studies are focused on encapsulation of hydrophobic drugs, delivery of hydrophilic compounds is typically performed via covalent attachment, which often requires chemical modification of the drug and limits the release kinetics. In this paper, we report synthesis of biphilic copolymers of various compositions capable of self-assembly in water with the formation of nanoparticles and suitable for ionic binding of the common anticancer drug doxorubicin. The copolymers are synthesized by radical copolymerization of N-vinyl-2-pyrrolidone and acrylic acid using n-octadecyl-mercaptan as a chain transfer agent. With an increase of the carboxyl group’s share in the chain, the role of the electrostatic stabilization factor of the nanoparticles increased as well as the ability of doxorubicin as an ion binder. A mathematical description of the kinetics of doxorubicin binding and release is given and thermodynamic functions for the equilibrium ionic binding of doxorubicin are calculated.
format Online
Article
Text
id pubmed-9609473
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96094732022-10-28 Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin Artyukhov, Alexander A. Nechaeva, Anna M. Shtilman, Mikhail I. Chistyakov, Evgeniy M. Svistunova, Alina Yu. Bagrov, Dmitry V. Kuskov, Andrey N. Docea, Anca O. Tsatsakis, Aristides M. Gurevich, Leonid Mezhuev, Yaroslav O. Materials (Basel) Article Application of nanocarriers for drug delivery brings numerous advantages, allowing both minimization of side effects common in systemic drug delivery and improvement in targeting, which has made it the focal point of nanoscience for a number of years. While most of the studies are focused on encapsulation of hydrophobic drugs, delivery of hydrophilic compounds is typically performed via covalent attachment, which often requires chemical modification of the drug and limits the release kinetics. In this paper, we report synthesis of biphilic copolymers of various compositions capable of self-assembly in water with the formation of nanoparticles and suitable for ionic binding of the common anticancer drug doxorubicin. The copolymers are synthesized by radical copolymerization of N-vinyl-2-pyrrolidone and acrylic acid using n-octadecyl-mercaptan as a chain transfer agent. With an increase of the carboxyl group’s share in the chain, the role of the electrostatic stabilization factor of the nanoparticles increased as well as the ability of doxorubicin as an ion binder. A mathematical description of the kinetics of doxorubicin binding and release is given and thermodynamic functions for the equilibrium ionic binding of doxorubicin are calculated. MDPI 2022-10-13 /pmc/articles/PMC9609473/ /pubmed/36295201 http://dx.doi.org/10.3390/ma15207136 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Artyukhov, Alexander A.
Nechaeva, Anna M.
Shtilman, Mikhail I.
Chistyakov, Evgeniy M.
Svistunova, Alina Yu.
Bagrov, Dmitry V.
Kuskov, Andrey N.
Docea, Anca O.
Tsatsakis, Aristides M.
Gurevich, Leonid
Mezhuev, Yaroslav O.
Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin
title Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin
title_full Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin
title_fullStr Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin
title_full_unstemmed Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin
title_short Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin
title_sort nanoaggregates of biphilic carboxyl-containing copolymers as carriers for ionically bound doxorubicin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609473/
https://www.ncbi.nlm.nih.gov/pubmed/36295201
http://dx.doi.org/10.3390/ma15207136
work_keys_str_mv AT artyukhovalexandera nanoaggregatesofbiphiliccarboxylcontainingcopolymersascarriersforionicallybounddoxorubicin
AT nechaevaannam nanoaggregatesofbiphiliccarboxylcontainingcopolymersascarriersforionicallybounddoxorubicin
AT shtilmanmikhaili nanoaggregatesofbiphiliccarboxylcontainingcopolymersascarriersforionicallybounddoxorubicin
AT chistyakovevgeniym nanoaggregatesofbiphiliccarboxylcontainingcopolymersascarriersforionicallybounddoxorubicin
AT svistunovaalinayu nanoaggregatesofbiphiliccarboxylcontainingcopolymersascarriersforionicallybounddoxorubicin
AT bagrovdmitryv nanoaggregatesofbiphiliccarboxylcontainingcopolymersascarriersforionicallybounddoxorubicin
AT kuskovandreyn nanoaggregatesofbiphiliccarboxylcontainingcopolymersascarriersforionicallybounddoxorubicin
AT doceaancao nanoaggregatesofbiphiliccarboxylcontainingcopolymersascarriersforionicallybounddoxorubicin
AT tsatsakisaristidesm nanoaggregatesofbiphiliccarboxylcontainingcopolymersascarriersforionicallybounddoxorubicin
AT gurevichleonid nanoaggregatesofbiphiliccarboxylcontainingcopolymersascarriersforionicallybounddoxorubicin
AT mezhuevyaroslavo nanoaggregatesofbiphiliccarboxylcontainingcopolymersascarriersforionicallybounddoxorubicin