A Deletion Encompassing the Furin Cleavage Site in the Spike Encoding Gene Does Not Alter SARS-CoV-2 Replication in Lung Tissues of Mink and Neutralization by Convalescent Human Serum Samples

SARS-CoV-2 has been shown to lose the furin polybasic cleavage site (FCS) following adaptation on cell culture. Deletion occurring in this region, which may include also the FCS flanking regions, seem not to affect virus replication in vitro; however, a chimeric SARS-CoV-2 virus without the sole FCS...

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Detalles Bibliográficos
Autores principales: Valleriani, Fabrizia, Jurisic, Lucija, Di Pancrazio, Chiara, Irelli, Roberta, Ciarrocchi, Eugenia, Martino, Michele, Cocco, Antonio, Di Felice, Elisabetta, Colaianni, Maria Loredana, Decaro, Nicola, Bonfini, Barbara, Lorusso, Alessio, Di Teodoro, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609486/
https://www.ncbi.nlm.nih.gov/pubmed/36297209
http://dx.doi.org/10.3390/pathogens11101152

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