Mitsunobu Reaction: A Powerful Tool for the Synthesis of Natural Products: A Review

The Mitsunobu reaction plays a vital part in organic chemistry due to its wide synthetic applications. It is considered as a significant reaction for the interconversion of one functional group (alcohol) to another (ester) in the presence of oxidizing agents (azodicarboxylates) and reducing agents (...

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Autores principales: Munawar, Saba, Zahoor, Ameer Fawad, Ali, Shafaqat, Javed, Sadia, Irfan, Muhammad, Irfan, Ali, Kotwica-Mojzych, Katarzyna, Mojzych, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609662/
https://www.ncbi.nlm.nih.gov/pubmed/36296545
http://dx.doi.org/10.3390/molecules27206953
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author Munawar, Saba
Zahoor, Ameer Fawad
Ali, Shafaqat
Javed, Sadia
Irfan, Muhammad
Irfan, Ali
Kotwica-Mojzych, Katarzyna
Mojzych, Mariusz
author_facet Munawar, Saba
Zahoor, Ameer Fawad
Ali, Shafaqat
Javed, Sadia
Irfan, Muhammad
Irfan, Ali
Kotwica-Mojzych, Katarzyna
Mojzych, Mariusz
author_sort Munawar, Saba
collection PubMed
description The Mitsunobu reaction plays a vital part in organic chemistry due to its wide synthetic applications. It is considered as a significant reaction for the interconversion of one functional group (alcohol) to another (ester) in the presence of oxidizing agents (azodicarboxylates) and reducing agents (phosphines). It is a renowned stereoselective reaction which inverts the stereochemical configuration of end products. One of the most important applications of the Mitsunobu reaction is its role in the synthesis of natural products. This review article will focus on the contribution of the Mitsunobu reaction towards the total synthesis of natural products, highlighting their biological potential during recent years.
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spelling pubmed-96096622022-10-28 Mitsunobu Reaction: A Powerful Tool for the Synthesis of Natural Products: A Review Munawar, Saba Zahoor, Ameer Fawad Ali, Shafaqat Javed, Sadia Irfan, Muhammad Irfan, Ali Kotwica-Mojzych, Katarzyna Mojzych, Mariusz Molecules Review The Mitsunobu reaction plays a vital part in organic chemistry due to its wide synthetic applications. It is considered as a significant reaction for the interconversion of one functional group (alcohol) to another (ester) in the presence of oxidizing agents (azodicarboxylates) and reducing agents (phosphines). It is a renowned stereoselective reaction which inverts the stereochemical configuration of end products. One of the most important applications of the Mitsunobu reaction is its role in the synthesis of natural products. This review article will focus on the contribution of the Mitsunobu reaction towards the total synthesis of natural products, highlighting their biological potential during recent years. MDPI 2022-10-17 /pmc/articles/PMC9609662/ /pubmed/36296545 http://dx.doi.org/10.3390/molecules27206953 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Munawar, Saba
Zahoor, Ameer Fawad
Ali, Shafaqat
Javed, Sadia
Irfan, Muhammad
Irfan, Ali
Kotwica-Mojzych, Katarzyna
Mojzych, Mariusz
Mitsunobu Reaction: A Powerful Tool for the Synthesis of Natural Products: A Review
title Mitsunobu Reaction: A Powerful Tool for the Synthesis of Natural Products: A Review
title_full Mitsunobu Reaction: A Powerful Tool for the Synthesis of Natural Products: A Review
title_fullStr Mitsunobu Reaction: A Powerful Tool for the Synthesis of Natural Products: A Review
title_full_unstemmed Mitsunobu Reaction: A Powerful Tool for the Synthesis of Natural Products: A Review
title_short Mitsunobu Reaction: A Powerful Tool for the Synthesis of Natural Products: A Review
title_sort mitsunobu reaction: a powerful tool for the synthesis of natural products: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609662/
https://www.ncbi.nlm.nih.gov/pubmed/36296545
http://dx.doi.org/10.3390/molecules27206953
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