Cargando…

Proinflammatory Innate Cytokines and Distinct Metabolomic Signatures Shape the T Cell Response in Active COVID-19

The underlying factors contributing to the evolution of SARS-CoV-2-specific T cell responses during COVID-19 infection remain unidentified. To address this, we characterized innate and adaptive immune responses with metabolomic profiling longitudinally at three different time points (0–3, 7–9, and 1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Binayke, Akshay, Zaheer, Aymaan, Dandotiya, Jyotsna, Gupta, Sonu Kumar, Mani, Shailendra, Tripathy, Manas Ranjan, Madan, Upasna, Shrivastava, Tripti, Kumar, Yashwant, Pandey, Anil Kumar, Rathore, Deepak Kumar, Awasthi, Amit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609972/ https://www.ncbi.nlm.nih.gov/pubmed/36298628 http://dx.doi.org/10.3390/vaccines10101762

Ejemplares similares

Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2022)

IL-9 aggravates SARS-CoV-2 infection and exacerbates associated airway inflammation
por: Sadhu, Srikanth, et al.
Publicado: (2023)

High-salt diet mediates interplay between NK cells and gut microbiota to induce potent tumor immunity
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2021)

Evaluation of Ayush-64 (a Polyherbal Formulation) and Its Ingredients in the Syrian Hamster Model for SARS-CoV-2 Infection Reveals the Preventative Potential of Alstonia scholaris
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2023)

Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2022)

Pharmacological potential of Withania somnifera (L.) Dunal and Tinospora cordifolia (Willd.) Miers on the experimental models of COVID-19, T cell differentiation, and neutrophil functions
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2023)

Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: a test-negative, case-control study and a mechanistic study of post-vaccination immune responses
por: Thiruvengadam, Ramachandran, et al.
Publicado: (2022)

Immunogenicity and safety of Biological E’s CORBEVAX™ vaccine compared to COVISHIELD™ (ChAdOx1 nCoV-19) vaccine studied in a phase-3, single blind, multicentre, randomized clinical trial
por: Thuluva, Subhash, et al.
Publicado: (2023)

SARS-CoV-2 delta variant: a persistent threat to the effectiveness of vaccines
por: Thiruvengadam, Ramachandran, et al.
Publicado: (2022)

Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2023)

A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern
por: Parray, Hilal Ahmad, et al.
Publicado: (2022)

Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Based Novel Epitopes Induce Potent Immune Responses in vivo and Inhibit Viral Replication in vitro
por: Vishwakarma, Preeti, et al.
Publicado: (2021)

Gefitinib Results in Robust Host-Directed Immunity Against Salmonella Infection Through Proteo-Metabolomic Reprogramming
por: Sadhu, Srikanth, et al.
Publicado: (2021)

Clinical and experimental evidence suggest omicron variant of SARS-CoV-2 is inherently less pathogenic than delta variant independent of previous immunity
por: Thiruvengadam, Ramachandran, et al.
Publicado: (2023)

Identification of an anti–SARS–CoV-2 receptor-binding domain–directed human monoclonal antibody from a naïve semisynthetic library
por: Parray, Hilal Ahmad, et al.
Publicado: (2020)

Metabolomic analysis of primary human skeletal muscle cells during myogenic progression
por: Kumar, Ashok, et al.
Publicado: (2020)

The SARS CoV-2 spike directed non-neutralizing polyclonal antibodies cross-react with Human immunodeficiency virus (HIV-1) gp41
por: Perween, Reshma, et al.
Publicado: (2021)

Forecasting suicide rates in India: An empirical exposition
por: Swain, Prafulla Kumar, et al.
Publicado: (2021)

Effect of Prophylactic Use of Intranasal Oil Formulations in the Hamster Model of COVID-19
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2021)

Analysis of Salmonella enterica Serovar Typhi by Outer Membrane Protein (OMP) Profiling, Random Amplification of Polymorphic DNA (RAPD) and Pulsed Field Gel Electrophoresis (PFGE)
por: Kumar, Yashwant, et al.
Publicado: (2019)

Comparative Immunomodulatory Evaluation of the Receptor Binding Domain of the SARS-CoV-2 Spike Protein; a Potential Vaccine Candidate Which Imparts Potent Humoral and Th1 Type Immune Response in a Mouse Model
por: Shrivastava, Tripti, et al.
Publicado: (2021)

Diffusion Tensor and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Correlate with Molecular Markers of Inflammation in the Synovium
por: Tripathi, Deepak, et al.
Publicado: (2022)

Detection of COVID19 from X-ray images using multiscale Deep Convolutional Neural Network
por: Muralidharan, Neha, et al.
Publicado: (2022)

Characterization of a broadly cross reactive tetravalent human monoclonal antibody, recognizing conformational epitopes in receptor binding domain of SARS-CoV-2
por: Garg, Sonal, et al.
Publicado: (2022)

Identification of metabolite extraction method for targeted exploration of antimicrobial resistance associated metabolites of Klebsiella pneumoniae
por: Kumar, Ashok, et al.
Publicado: (2022)

Author Correction: Au nanoparticles modified CuO nanowire electrode based non-enzymatic glucose detection with improved linearity
por: Mishra, Ashwini Kumar, et al.
Publicado: (2020)

Au nanoparticles modified CuO nanowire electrode based non-enzymatic glucose detection with improved linearity
por: Mishra, Ashwini Kumar, et al.
Publicado: (2020)

Effectiveness of various communication strategies for improving childhood pneumonia case management: a community based behavioral open labeled trial in rural Lucknow, Uttar Pradesh, India
por: Awasthi, Shally, et al.
Publicado: (2019)

Japanese Encephalitis Virus Infected Human Monocyte-Derived Dendritic Cells Activate a Transcriptional Network Leading to an Antiviral Inflammatory Response
por: Chauhan, Shailendra, et al.
Publicado: (2021)

Characterization of antimicrobial resistance markers & their stability in Salmonella enterica serovar Typhi
por: Kumar, Yashwant, et al.
Publicado: (2017)

Compliance monitoring of prohibition of smoking (under section-4 of COTPA) at a tertiary health-care institution in a smoke-free city of India
por: Tripathy, Jaya Prasad, et al.
Publicado: (2013)

Measuring and understanding motivation among community health workers in rural health facilities in India-a mixed method study
por: Tripathy, Jaya Prasad, et al.
Publicado: (2016)

Systems Biology to Understand and Regulate Human Retroviral Proinflammatory Response
por: Helmy, Mohamed, et al.
Publicado: (2021)

Novel optical coherence tomography angiography biomarkers in the diagnosis and assessment of diabetic macular edema and diabetic macular ischemia in patients with non-proliferative diabetic retinopathy
por: Thaker, Shivna, et al.
Publicado: (2023)

Antibody-based therapeutic interventions: possible strategy to counter chikungunya viral infection
por: Kumar, Rajesh, et al.
Publicado: (2020)

Simvastatin Restores HDAC1/2 Activity and Improves Behavioral Deficits in Angelman Syndrome Model Mouse
por: Kumar, Vipendra, et al.
Publicado: (2019)

Amaranthus Biochar-Based Microbial Cell Composites for Alleviation of Drought and Cadmium Stress: A Novel Bioremediation Approach
por: Tripti,, et al.
Publicado: (2023)

Evaluation of performance of C-MAC(®) video laryngoscope Miller blade size zero for endotracheal intubation in preterm and ex-preterm infants: A retrospective analysis
por: Sinha, Renu, et al.
Publicado: (2019)

Mosquito Innate Immunity
por: Kumar, Ankit, et al.
Publicado: (2018)

Prognostic value of TNF-α-308 and IFN-γ-874 single nucleotide polymorphisms and their plasma levels in patients with aplastic anemia
por: Shukla, Saurabh, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dogog5cdgoa1c7a58m8fjutiuj