Design, Synthesis and Biological Evaluation of Biscarbamates as Potential Selective Butyrylcholinesterase Inhibitors for the Treatment of Alzheimer’s Disease

As butyrylcholinesterase (BChE) plays a role in the progression of symptoms and pathophysiology of Alzheimer’s disease (AD), selective inhibition of BChE over acetylcholinesterase (AChE) can represent a promising pathway in treating AD. The carbamate group was chosen as a pharmacophore because the c...

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Detalles Bibliográficos
Autores principales: Matošević, Ana, Knežević, Anamarija, Zandona, Antonio, Maraković, Nikola, Kovarik, Zrinka, Bosak, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609992/
https://www.ncbi.nlm.nih.gov/pubmed/36297332
http://dx.doi.org/10.3390/ph15101220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609992/
https://www.ncbi.nlm.nih.gov/pubmed/36297332
http://dx.doi.org/10.3390/ph15101220

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