Design and Synthesis of Aminopyrimidinyl Pyrazole Analogs as PLK1 Inhibitors Using Hybrid 3D-QSAR and Molecular Docking

Cancer continues to be one of the world’s most severe public health issues. Polo-like kinase 1 (PLK1) is one of the most studied members of the polo-like kinase subfamily of serine/threonine protein kinases. PLK1 is a key mitotic regulator responsible for cell cycle processes, such as mitosis initia...

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Detalles Bibliográficos
Autores principales: Bhujbal, Swapnil P., Kim, Hyejin, Bae, Hyunah, Hah, Jung-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610081/
https://www.ncbi.nlm.nih.gov/pubmed/36297281
http://dx.doi.org/10.3390/ph15101170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610081/
https://www.ncbi.nlm.nih.gov/pubmed/36297281
http://dx.doi.org/10.3390/ph15101170

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