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Viral Hepatitis A, B and C in a Group of Transgender Women in Central Brazil
Transgender women (TGW) have limited access to affordable viral hepatitis testing, hepatitis B vaccination, and treatment. We aimed to estimate the prevalence of viral hepatitis A, B, and C, as well as to compare the adherence and immunogenicity of two hepatitis B vaccine schedules among TGW in Cent...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610098/ https://www.ncbi.nlm.nih.gov/pubmed/36288010 http://dx.doi.org/10.3390/tropicalmed7100269 |
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author | Ferri, Lucila Pessuti Junqueira, Priscilla dos Santos de Almeida, Mayara Maria Souza Oliveira, Mariana Gomes de Oliveira, Brunna Rodrigues Diniz e Silva, Bruno Vinícius Magalhães, Larissa Silva Villar, Lívia Melo Caetano, Karlla Antonieta Amorim Souza, Márcia Maria Carneiro, Megmar Aparecida dos Santos Martins, Regina Maria Bringel Teles, Sheila Araujo |
author_facet | Ferri, Lucila Pessuti Junqueira, Priscilla dos Santos de Almeida, Mayara Maria Souza Oliveira, Mariana Gomes de Oliveira, Brunna Rodrigues Diniz e Silva, Bruno Vinícius Magalhães, Larissa Silva Villar, Lívia Melo Caetano, Karlla Antonieta Amorim Souza, Márcia Maria Carneiro, Megmar Aparecida dos Santos Martins, Regina Maria Bringel Teles, Sheila Araujo |
author_sort | Ferri, Lucila Pessuti |
collection | PubMed |
description | Transgender women (TGW) have limited access to affordable viral hepatitis testing, hepatitis B vaccination, and treatment. We aimed to estimate the prevalence of viral hepatitis A, B, and C, as well as to compare the adherence and immunogenicity of two hepatitis B vaccine schedules among TGW in Central Brazil. A total of 440 TGW were interviewed and tested for hepatitis A, B, and C serological markers from 2017 to 2018. The hepatitis B vaccine was offered to 230 eligible TGW: 112 received a super accelerated hepatitis B vaccine schedule (G1) and 118 a standard schedule (G2). The antibody against the hepatitis A virus (HAV) was detected in 75.63% of the participants, and 12.3% of the TGW were exposed to the hepatitis B virus (HBV). Two (0.46%) participants were HBV carriers. Only 41.5% of the participants showed a serological profile of hepatitis B vaccination. The antibody against the hepatitis C virus (anti-HCV) was found in six participants (1.37%). Of the TGW who received the first vaccine dose, 62 (55.36%) and 49 (41.52%) in G1 and G2, respectively, received three doses (p = 0.036). The vaccine response was evaluated in 28 G1 and 22 G2 TGW; of these, 89.3% and 100% developed protective anti-hepatitis B surface-antigen titers, respectively (p = 0.113). Since one-third of younger transgender women are susceptible to HAV, hepatitis B immunization is low, and the anti-HCV rate is higher in this group than in the general population in Central Brazil, public-health attention is warranted. The super-accelerated scheme demonstrated better adhesion and good immunogenicity, suggesting that it would be a more cost-effective solution. |
format | Online Article Text |
id | pubmed-9610098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96100982022-10-28 Viral Hepatitis A, B and C in a Group of Transgender Women in Central Brazil Ferri, Lucila Pessuti Junqueira, Priscilla dos Santos de Almeida, Mayara Maria Souza Oliveira, Mariana Gomes de Oliveira, Brunna Rodrigues Diniz e Silva, Bruno Vinícius Magalhães, Larissa Silva Villar, Lívia Melo Caetano, Karlla Antonieta Amorim Souza, Márcia Maria Carneiro, Megmar Aparecida dos Santos Martins, Regina Maria Bringel Teles, Sheila Araujo Trop Med Infect Dis Article Transgender women (TGW) have limited access to affordable viral hepatitis testing, hepatitis B vaccination, and treatment. We aimed to estimate the prevalence of viral hepatitis A, B, and C, as well as to compare the adherence and immunogenicity of two hepatitis B vaccine schedules among TGW in Central Brazil. A total of 440 TGW were interviewed and tested for hepatitis A, B, and C serological markers from 2017 to 2018. The hepatitis B vaccine was offered to 230 eligible TGW: 112 received a super accelerated hepatitis B vaccine schedule (G1) and 118 a standard schedule (G2). The antibody against the hepatitis A virus (HAV) was detected in 75.63% of the participants, and 12.3% of the TGW were exposed to the hepatitis B virus (HBV). Two (0.46%) participants were HBV carriers. Only 41.5% of the participants showed a serological profile of hepatitis B vaccination. The antibody against the hepatitis C virus (anti-HCV) was found in six participants (1.37%). Of the TGW who received the first vaccine dose, 62 (55.36%) and 49 (41.52%) in G1 and G2, respectively, received three doses (p = 0.036). The vaccine response was evaluated in 28 G1 and 22 G2 TGW; of these, 89.3% and 100% developed protective anti-hepatitis B surface-antigen titers, respectively (p = 0.113). Since one-third of younger transgender women are susceptible to HAV, hepatitis B immunization is low, and the anti-HCV rate is higher in this group than in the general population in Central Brazil, public-health attention is warranted. The super-accelerated scheme demonstrated better adhesion and good immunogenicity, suggesting that it would be a more cost-effective solution. MDPI 2022-09-27 /pmc/articles/PMC9610098/ /pubmed/36288010 http://dx.doi.org/10.3390/tropicalmed7100269 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ferri, Lucila Pessuti Junqueira, Priscilla dos Santos de Almeida, Mayara Maria Souza Oliveira, Mariana Gomes de Oliveira, Brunna Rodrigues Diniz e Silva, Bruno Vinícius Magalhães, Larissa Silva Villar, Lívia Melo Caetano, Karlla Antonieta Amorim Souza, Márcia Maria Carneiro, Megmar Aparecida dos Santos Martins, Regina Maria Bringel Teles, Sheila Araujo Viral Hepatitis A, B and C in a Group of Transgender Women in Central Brazil |
title | Viral Hepatitis A, B and C in a Group of Transgender Women in Central Brazil |
title_full | Viral Hepatitis A, B and C in a Group of Transgender Women in Central Brazil |
title_fullStr | Viral Hepatitis A, B and C in a Group of Transgender Women in Central Brazil |
title_full_unstemmed | Viral Hepatitis A, B and C in a Group of Transgender Women in Central Brazil |
title_short | Viral Hepatitis A, B and C in a Group of Transgender Women in Central Brazil |
title_sort | viral hepatitis a, b and c in a group of transgender women in central brazil |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610098/ https://www.ncbi.nlm.nih.gov/pubmed/36288010 http://dx.doi.org/10.3390/tropicalmed7100269 |
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