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Immunocompetent patient with isolated primary fourth ventricle lymphoma. Unusual diagnosis, their pitfalls, and challenges
BACKGROUND: Primary central nervous system lymphoma (PCNSL) is an uncommon lesion and represent 4% of all central nervous system (CNS) cancers. There have been few reports of localized isolated lymphoma developing in the fourth ventricle, with only 8 previous cases described. We present a case of an...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Scientific Scholar
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610116/ https://www.ncbi.nlm.nih.gov/pubmed/36324945 http://dx.doi.org/10.25259/SNI_584_2022 |
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author | Holanda, Tiago S. F. Pimentel, Isnara Mara Freitas Gosch, Gabriela Oliveira Tavora, Daniel Gurgel Fernandes Bandeira, Luiz Anderson Bevilaqua Filho, Flavio Leitao |
author_facet | Holanda, Tiago S. F. Pimentel, Isnara Mara Freitas Gosch, Gabriela Oliveira Tavora, Daniel Gurgel Fernandes Bandeira, Luiz Anderson Bevilaqua Filho, Flavio Leitao |
author_sort | Holanda, Tiago S. F. |
collection | PubMed |
description | BACKGROUND: Primary central nervous system lymphoma (PCNSL) is an uncommon lesion and represent 4% of all central nervous system (CNS) cancers. There have been few reports of localized isolated lymphoma developing in the fourth ventricle, with only 8 previous cases described. We present a case of an immunocompetent patient with isolated fourth ventricle lymphoma who did not have diffusion-weighted imaging (DWI) restriction. CASE DESCRIPTION: A 45-year-old man presented a history of headache, vomiting and weigh loss. Upon clinical examination, he presented bilateral papilledema, multidirectional nystagmus, and gait imbalance. Magnetic resonance imaging showed a solid tumor in fourth ventricle with 1.8 × 1.6 × 1.1 cm. The patient was submitted to a suboccipital telovelar approach. The pathological study showed a neoplasm composed of loose round cells. Immunohistochemistry showed positivity for CD-45 and CD-23. The diagnosis of primary CNS lymphoma of the fourth ventricle was certified. Patient was sent to complementary treatment with hematologist and radiotherapy and chemotherapy were started. CONCLUSION: PCNSL is a rare and aggressive pathology with high rates of mortality and recurrence. It requires a multidisciplinary team and multiple therapies to control the disease and deliver better quality of life and prognosis to the patient. |
format | Online Article Text |
id | pubmed-9610116 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Scientific Scholar |
record_format | MEDLINE/PubMed |
spelling | pubmed-96101162022-11-01 Immunocompetent patient with isolated primary fourth ventricle lymphoma. Unusual diagnosis, their pitfalls, and challenges Holanda, Tiago S. F. Pimentel, Isnara Mara Freitas Gosch, Gabriela Oliveira Tavora, Daniel Gurgel Fernandes Bandeira, Luiz Anderson Bevilaqua Filho, Flavio Leitao Surg Neurol Int Case Report BACKGROUND: Primary central nervous system lymphoma (PCNSL) is an uncommon lesion and represent 4% of all central nervous system (CNS) cancers. There have been few reports of localized isolated lymphoma developing in the fourth ventricle, with only 8 previous cases described. We present a case of an immunocompetent patient with isolated fourth ventricle lymphoma who did not have diffusion-weighted imaging (DWI) restriction. CASE DESCRIPTION: A 45-year-old man presented a history of headache, vomiting and weigh loss. Upon clinical examination, he presented bilateral papilledema, multidirectional nystagmus, and gait imbalance. Magnetic resonance imaging showed a solid tumor in fourth ventricle with 1.8 × 1.6 × 1.1 cm. The patient was submitted to a suboccipital telovelar approach. The pathological study showed a neoplasm composed of loose round cells. Immunohistochemistry showed positivity for CD-45 and CD-23. The diagnosis of primary CNS lymphoma of the fourth ventricle was certified. Patient was sent to complementary treatment with hematologist and radiotherapy and chemotherapy were started. CONCLUSION: PCNSL is a rare and aggressive pathology with high rates of mortality and recurrence. It requires a multidisciplinary team and multiple therapies to control the disease and deliver better quality of life and prognosis to the patient. Scientific Scholar 2022-10-14 /pmc/articles/PMC9610116/ /pubmed/36324945 http://dx.doi.org/10.25259/SNI_584_2022 Text en Copyright: © 2022 Surgical Neurology International https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Holanda, Tiago S. F. Pimentel, Isnara Mara Freitas Gosch, Gabriela Oliveira Tavora, Daniel Gurgel Fernandes Bandeira, Luiz Anderson Bevilaqua Filho, Flavio Leitao Immunocompetent patient with isolated primary fourth ventricle lymphoma. Unusual diagnosis, their pitfalls, and challenges |
title | Immunocompetent patient with isolated primary fourth ventricle lymphoma. Unusual diagnosis, their pitfalls, and challenges |
title_full | Immunocompetent patient with isolated primary fourth ventricle lymphoma. Unusual diagnosis, their pitfalls, and challenges |
title_fullStr | Immunocompetent patient with isolated primary fourth ventricle lymphoma. Unusual diagnosis, their pitfalls, and challenges |
title_full_unstemmed | Immunocompetent patient with isolated primary fourth ventricle lymphoma. Unusual diagnosis, their pitfalls, and challenges |
title_short | Immunocompetent patient with isolated primary fourth ventricle lymphoma. Unusual diagnosis, their pitfalls, and challenges |
title_sort | immunocompetent patient with isolated primary fourth ventricle lymphoma. unusual diagnosis, their pitfalls, and challenges |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610116/ https://www.ncbi.nlm.nih.gov/pubmed/36324945 http://dx.doi.org/10.25259/SNI_584_2022 |
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