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Evaluation of Simplified Diet Scores Related to C-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening

The aim of this study was to assess the relationship between adherence to a healthy diet, such as the Mediterranean diet (MedDiet), and C-reactive protein (CRP) in Italian heavy smokers undergoing an LDCT screening program (bioMILD trial), using scores calculated by simple questionnaires. Simple for...

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Autores principales: Sabia, Federica, Borgo, Alessandra, Lugo, Alessandra, Suatoni, Paola, Morelli, Daniele, Gallus, Silvano, Villarini, Anna, Pastorino, Ugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610125/
https://www.ncbi.nlm.nih.gov/pubmed/36296996
http://dx.doi.org/10.3390/nu14204312
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author Sabia, Federica
Borgo, Alessandra
Lugo, Alessandra
Suatoni, Paola
Morelli, Daniele
Gallus, Silvano
Villarini, Anna
Pastorino, Ugo
author_facet Sabia, Federica
Borgo, Alessandra
Lugo, Alessandra
Suatoni, Paola
Morelli, Daniele
Gallus, Silvano
Villarini, Anna
Pastorino, Ugo
author_sort Sabia, Federica
collection PubMed
description The aim of this study was to assess the relationship between adherence to a healthy diet, such as the Mediterranean diet (MedDiet), and C-reactive protein (CRP) in Italian heavy smokers undergoing an LDCT screening program (bioMILD trial), using scores calculated by simple questionnaires. Simple formats of food frequency questionnaires were administered to a sample of 2438 volunteers, and the adherence to a healthy diet was measured by the validated 14-point MEDAS and by two adaptations proposed by us: 17-item revised-MEDAS and 18-item revised-MEDAS. The OR of CRP ≥ 2 mg/L for 1-point increase in 14-point MEDAS score was 0.95 (95% CI 0.91–0.99), for 17-point score was 0.94 (95% CI 0.91–0.98), and for 18-point score was 0.92 (95% CI 0.88–0.97). These inverse associations remained statistically significant also after further adjustment for body mass index. These results showed the efficacy of simplified scores and their relationship with lower levels of CRP in a population of heavy smokers. This suggests that a targeted nutritional intervention might achieve a substantial reduction in CRP levels. The findings will be prospectively tested in a new randomized study on primary prevention during lung cancer screening.
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spelling pubmed-96101252022-10-28 Evaluation of Simplified Diet Scores Related to C-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening Sabia, Federica Borgo, Alessandra Lugo, Alessandra Suatoni, Paola Morelli, Daniele Gallus, Silvano Villarini, Anna Pastorino, Ugo Nutrients Article The aim of this study was to assess the relationship between adherence to a healthy diet, such as the Mediterranean diet (MedDiet), and C-reactive protein (CRP) in Italian heavy smokers undergoing an LDCT screening program (bioMILD trial), using scores calculated by simple questionnaires. Simple formats of food frequency questionnaires were administered to a sample of 2438 volunteers, and the adherence to a healthy diet was measured by the validated 14-point MEDAS and by two adaptations proposed by us: 17-item revised-MEDAS and 18-item revised-MEDAS. The OR of CRP ≥ 2 mg/L for 1-point increase in 14-point MEDAS score was 0.95 (95% CI 0.91–0.99), for 17-point score was 0.94 (95% CI 0.91–0.98), and for 18-point score was 0.92 (95% CI 0.88–0.97). These inverse associations remained statistically significant also after further adjustment for body mass index. These results showed the efficacy of simplified scores and their relationship with lower levels of CRP in a population of heavy smokers. This suggests that a targeted nutritional intervention might achieve a substantial reduction in CRP levels. The findings will be prospectively tested in a new randomized study on primary prevention during lung cancer screening. MDPI 2022-10-15 /pmc/articles/PMC9610125/ /pubmed/36296996 http://dx.doi.org/10.3390/nu14204312 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sabia, Federica
Borgo, Alessandra
Lugo, Alessandra
Suatoni, Paola
Morelli, Daniele
Gallus, Silvano
Villarini, Anna
Pastorino, Ugo
Evaluation of Simplified Diet Scores Related to C-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening
title Evaluation of Simplified Diet Scores Related to C-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening
title_full Evaluation of Simplified Diet Scores Related to C-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening
title_fullStr Evaluation of Simplified Diet Scores Related to C-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening
title_full_unstemmed Evaluation of Simplified Diet Scores Related to C-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening
title_short Evaluation of Simplified Diet Scores Related to C-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening
title_sort evaluation of simplified diet scores related to c-reactive protein in heavy smokers undergoing lung cancer screening
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610125/
https://www.ncbi.nlm.nih.gov/pubmed/36296996
http://dx.doi.org/10.3390/nu14204312
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