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Magnesium Potentiates the Vortioxetine’s Effects on Physical Performances and Biological Changes in Exercise-Induced Stress in Rats

Background and objectives: Vortioxetine (VRT) is a relatively new selective serotonin reuptake inhibitor (SSRI) antidepressant and serotonin receptor modulator, approved for the treatment of major depression and generalized anxiety disorder. Depression has been linked with psychomotor disengagement,...

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Autores principales: Fotache, Paula Alina, Mititelu-Tartau, Liliana, Bogdan, Maria, Buca, Beatrice Rozalina, Pavel, Liliana Lacramioara, Pelin, Ana-Maria, Meca, Andreea-Daniela, Tartau, Cosmin-Gabriel, Popa, Gratiela Eliza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610293/
https://www.ncbi.nlm.nih.gov/pubmed/36295524
http://dx.doi.org/10.3390/medicina58101363
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author Fotache, Paula Alina
Mititelu-Tartau, Liliana
Bogdan, Maria
Buca, Beatrice Rozalina
Pavel, Liliana Lacramioara
Pelin, Ana-Maria
Meca, Andreea-Daniela
Tartau, Cosmin-Gabriel
Popa, Gratiela Eliza
author_facet Fotache, Paula Alina
Mititelu-Tartau, Liliana
Bogdan, Maria
Buca, Beatrice Rozalina
Pavel, Liliana Lacramioara
Pelin, Ana-Maria
Meca, Andreea-Daniela
Tartau, Cosmin-Gabriel
Popa, Gratiela Eliza
author_sort Fotache, Paula Alina
collection PubMed
description Background and objectives: Vortioxetine (VRT) is a relatively new selective serotonin reuptake inhibitor (SSRI) antidepressant and serotonin receptor modulator, approved for the treatment of major depression and generalized anxiety disorder. Depression has been linked with psychomotor disengagement, oxidative stress burden and decreased blood levels of brain-derived neurotrophic factor (BDNF). In our study we performed the experimental investigation of VRT, magnesium and of their association on the rats’ endurance capacity, motor behavior and blood biological disturbances in rats subjected to forced exercise in treadmill test. Materials and Methods: The substances were administered orally for 14 consecutive days, as follows: group 1 (control): distilled water 0.3 mL/100 g body; group 2 (Mg): magnesium chloride 200 mg/kg body; group 3 (VRT): VRT 20 mg/kg body; group 4 (VRT+Mg): VRT 20 mg/kg body + magnesium chloride 200 mg/kg body. Magnesium was used as positive control substance with known effects in treadmill test. The consequences of VRT treatment on glucose, cortisol, BDNF and oxidative stress biomarkers (superoxide-dismutase, malondialdehyde, glutathione-peroxidase, lactate dehydrogenase) were also assessed. Results and conclusions: The use of VRT resulted in an improvement in motor capacity and an increase of the rats’ endurance to physical effort. The administration of VRT increased the serum BDNF levels and reduced the oxidative stress in rats subjected to physical effort. The association of magnesium potentiated the effects of VRT on physical performances, the antioxidant activity and the decreasing in serum stress markers in treadmill test in rats.
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spelling pubmed-96102932022-10-28 Magnesium Potentiates the Vortioxetine’s Effects on Physical Performances and Biological Changes in Exercise-Induced Stress in Rats Fotache, Paula Alina Mititelu-Tartau, Liliana Bogdan, Maria Buca, Beatrice Rozalina Pavel, Liliana Lacramioara Pelin, Ana-Maria Meca, Andreea-Daniela Tartau, Cosmin-Gabriel Popa, Gratiela Eliza Medicina (Kaunas) Article Background and objectives: Vortioxetine (VRT) is a relatively new selective serotonin reuptake inhibitor (SSRI) antidepressant and serotonin receptor modulator, approved for the treatment of major depression and generalized anxiety disorder. Depression has been linked with psychomotor disengagement, oxidative stress burden and decreased blood levels of brain-derived neurotrophic factor (BDNF). In our study we performed the experimental investigation of VRT, magnesium and of their association on the rats’ endurance capacity, motor behavior and blood biological disturbances in rats subjected to forced exercise in treadmill test. Materials and Methods: The substances were administered orally for 14 consecutive days, as follows: group 1 (control): distilled water 0.3 mL/100 g body; group 2 (Mg): magnesium chloride 200 mg/kg body; group 3 (VRT): VRT 20 mg/kg body; group 4 (VRT+Mg): VRT 20 mg/kg body + magnesium chloride 200 mg/kg body. Magnesium was used as positive control substance with known effects in treadmill test. The consequences of VRT treatment on glucose, cortisol, BDNF and oxidative stress biomarkers (superoxide-dismutase, malondialdehyde, glutathione-peroxidase, lactate dehydrogenase) were also assessed. Results and conclusions: The use of VRT resulted in an improvement in motor capacity and an increase of the rats’ endurance to physical effort. The administration of VRT increased the serum BDNF levels and reduced the oxidative stress in rats subjected to physical effort. The association of magnesium potentiated the effects of VRT on physical performances, the antioxidant activity and the decreasing in serum stress markers in treadmill test in rats. MDPI 2022-09-28 /pmc/articles/PMC9610293/ /pubmed/36295524 http://dx.doi.org/10.3390/medicina58101363 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fotache, Paula Alina
Mititelu-Tartau, Liliana
Bogdan, Maria
Buca, Beatrice Rozalina
Pavel, Liliana Lacramioara
Pelin, Ana-Maria
Meca, Andreea-Daniela
Tartau, Cosmin-Gabriel
Popa, Gratiela Eliza
Magnesium Potentiates the Vortioxetine’s Effects on Physical Performances and Biological Changes in Exercise-Induced Stress in Rats
title Magnesium Potentiates the Vortioxetine’s Effects on Physical Performances and Biological Changes in Exercise-Induced Stress in Rats
title_full Magnesium Potentiates the Vortioxetine’s Effects on Physical Performances and Biological Changes in Exercise-Induced Stress in Rats
title_fullStr Magnesium Potentiates the Vortioxetine’s Effects on Physical Performances and Biological Changes in Exercise-Induced Stress in Rats
title_full_unstemmed Magnesium Potentiates the Vortioxetine’s Effects on Physical Performances and Biological Changes in Exercise-Induced Stress in Rats
title_short Magnesium Potentiates the Vortioxetine’s Effects on Physical Performances and Biological Changes in Exercise-Induced Stress in Rats
title_sort magnesium potentiates the vortioxetine’s effects on physical performances and biological changes in exercise-induced stress in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610293/
https://www.ncbi.nlm.nih.gov/pubmed/36295524
http://dx.doi.org/10.3390/medicina58101363
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