Synthesis, Biological Evaluation and Machine Learning Prediction Model for Fluorinated Cinchona Alkaloid-Based Derivatives as Cholinesterase Inhibitors

A series of 46 Cinchona alkaloid derivatives that differ in positions of fluorine atom(s) in the molecule were synthesized and tested as human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. All tested compounds reversibly inhibited AChE and BChE in the nanomolar to micromol...

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Detalles Bibliográficos
Autores principales: Ramić, Alma, Matošević, Ana, Debanić, Barbara, Mikelić, Ana, Primožič, Ines, Bosak, Anita, Hrenar, Tomica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610298/
https://www.ncbi.nlm.nih.gov/pubmed/36297327
http://dx.doi.org/10.3390/ph15101214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610298/
https://www.ncbi.nlm.nih.gov/pubmed/36297327
http://dx.doi.org/10.3390/ph15101214

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