Cargando…

The roles of connectivity and neuronal phenotype in determining the pattern of α-synuclein pathology in Parkinson's disease

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and motor dysfunction has been attributed to loss of dopaminergic neurons. However, motor dysfunction is only one of many symptoms experienced by patients. A neuropathological hallmark of PD is intraneuronal protei...

Descripción completa

Detalles Bibliográficos
Autores principales:	Henderson, Michael X., Henrich, Martin T., Geibl, Fanni F., Oertel, Wolfgang H., Brundin, Patrik, Surmeier, D. James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610381/ https://www.ncbi.nlm.nih.gov/pubmed/35283326 http://dx.doi.org/10.1016/j.nbd.2022.105687

Ejemplares similares

Determinants of seeding and spreading of α-synuclein pathology in the brain
por: Henrich, Martin T., et al.
Publicado: (2020)

Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential
por: Henrich, Martin T., et al.
Publicado: (2023)

A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson’s disease-like pathology in neurons and glia
por: Henrich, Martin Timo, et al.
Publicado: (2018)

Editorial: Targeting α-Synuclein in Parkinson's Disease and Multiple System Atrophy
por: Fellner, Lisa, et al.
Publicado: (2022)

Immunotherapy in Parkinson’s Disease: Micromanaging Alpha-Synuclein Aggregation
por: George, Sonia, et al.
Publicado: (2015)

What’s to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?
por: Dunning, Christopher J.R., et al.
Publicado: (2013)

Linking α-synuclein-induced synaptopathy and neural network dysfunction in early Parkinson’s disease
por: Kulkarni, Aishwarya S, et al.
Publicado: (2022)

Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala
por: Chen, Liqiang, et al.
Publicado: (2022)

Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein
por: Tyson, Trevor, et al.
Publicado: (2017)

Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link?
por: Lema Tomé, Carla M., et al.
Publicado: (2012)

Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation
por: Mezias, Christopher, et al.
Publicado: (2019)

α‐Synuclein: The Long Distance Runner
por: George, Sonia, et al.
Publicado: (2013)

Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease
por: Matschke, Lina A., et al.
Publicado: (2022)

Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease
por: George, Sonia, et al.
Publicado: (2019)

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons
por: Henderson, Michael X., et al.
Publicado: (2018)

Acceleration of α-Synuclein Aggregation by Exosomes
por: Grey, Marie, et al.
Publicado: (2015)

Initiation and progression of α-synuclein pathology in Parkinson’s disease
por: Tofaris, George K.
Publicado: (2022)

Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease
por: Yan, Shijun, et al.
Publicado: (2023)

T Cells Limit Accumulation of Aggregate Pathology Following Intrastriatal Injection of α-Synuclein Fibrils
por: George, Sonia, et al.
Publicado: (2021)

Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson’s disease
por: Kuan, Wei-Li, et al.
Publicado: (2019)

Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin
por: Kam, Tae-In, et al.
Publicado: (2022)

Association of Glial Activation and α-Synuclein Pathology in Parkinson’s Disease
por: Wang, Rui, et al.
Publicado: (2022)

Endogenous alpha-synuclein monomers, oligomers and resulting pathology: let’s talk about the lipids in the room
por: Killinger, Bryan A., et al.
Publicado: (2019)

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons
por: Zambon, Federico, et al.
Publicado: (2019)

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb
por: Rey, Nolwen L., et al.
Publicado: (2019)

Rasagiline Ameliorates Olfactory Deficits in an Alpha-Synuclein Mouse Model of Parkinson's Disease
por: Petit, Géraldine H., et al.
Publicado: (2013)

Progressive Olfactory Impairment and Cardiac Sympathetic Denervation in REM Sleep Behavior Disorder
por: Janzen, Annette, et al.
Publicado: (2022)

Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis
por: van den Berge, Simone A., et al.
Publicado: (2012)

Silica Nanoparticles Promote α-Synuclein Aggregation and Parkinson’s Disease Pathology
por: Yuan, Xin, et al.
Publicado: (2022)

Therapeutic functions of astrocytes to treat α-synuclein pathology in Parkinson’s disease
por: Yang, Yunseon, et al.
Publicado: (2022)

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice
por: Rey, Nolwen L., et al.
Publicado: (2013)

Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson’s disease
por: Grotemeyer, Alexander, et al.
Publicado: (2023)

Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons
por: Ganjam, Goutham K., et al.
Publicado: (2019)

Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo
por: Angot, Elodie, et al.
Publicado: (2012)

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term
por: Rey, Nolwen L., et al.
Publicado: (2017)

Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
por: Choi, Minee L., et al.
Publicado: (2022)

Early Forms of α-Synuclein Pathology Are Associated with Neuronal Complex I Deficiency in the Substantia Nigra of Individuals with Parkinson’s Disease
por: Flønes, Irene Hana, et al.
Publicado: (2022)

Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson's Disease: Who's on First?
por: Zaltieri, Michela, et al.
Publicado: (2015)

Role of α- and β-Synucleins in the Axonal Pathology of Parkinson’s Disease and Related Synucleinopathies
por: Sekigawa, Akio, et al.
Publicado: (2015)

Functionally different α-synuclein inclusions yield insight into Parkinson’s disease pathology
por: Raiss, Christian C., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_djfr939ecjm8j3f7iokingh2k0