Immunization with a Prefusion SARS-CoV-2 Spike Protein Vaccine (RBMRNA-176) Protects against Viral Challenge in Mice and Nonhuman Primates

There is an urgent need for a broad-spectrum and protective vaccine due to the emergence and rapid spreading of more contagious SARS-CoV-2 strains. We report the development of RBMRNA-176, a pseudouridine (Ψ) nucleoside-modified mRNA-LNP vaccine encoding pre-fusion stabilized trimeric SARS-CoV-2 spi...

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Detalles Bibliográficos
Autores principales: Ma, Qinhai, Li, Runfeng, Guo, Jianmin, Li, Man, Ma, Lin, Dai, Jun, Shi, Yongxia, Dai, Jinlong, Huang, Yuankeng, Dai, Cailing, Pan, Weiqi, Zhong, Huiling, Zhang, Hong, Wen, Jian, Zhao, Haoting, Wu, Linping, Yang, Wei, Zhang, Biliang, Yang, Zifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610403/
https://www.ncbi.nlm.nih.gov/pubmed/36298563
http://dx.doi.org/10.3390/vaccines10101698

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