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Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy

Nowadays, infectious diseases caused by microorganisms are a major threat to human health, mostly because of drug resistance, multi-drug resistance and extensive-drug-resistance phenomena to microbial pathogens. During the last few years, obtaining hybrid azaheterocyclic drugs represents a powerful...

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Detalles Bibliográficos
Autores principales: Amariucai-Mantu, Dorina, Mangalagiu, Violeta, Bejan, Iustinian, Aricu, Aculina, Mangalagiu, Ionel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610418/
https://www.ncbi.nlm.nih.gov/pubmed/36297461
http://dx.doi.org/10.3390/pharmaceutics14102026
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author Amariucai-Mantu, Dorina
Mangalagiu, Violeta
Bejan, Iustinian
Aricu, Aculina
Mangalagiu, Ionel I.
author_facet Amariucai-Mantu, Dorina
Mangalagiu, Violeta
Bejan, Iustinian
Aricu, Aculina
Mangalagiu, Ionel I.
author_sort Amariucai-Mantu, Dorina
collection PubMed
description Nowadays, infectious diseases caused by microorganisms are a major threat to human health, mostly because of drug resistance, multi-drug resistance and extensive-drug-resistance phenomena to microbial pathogens. During the last few years, obtaining hybrid azaheterocyclic drugs represents a powerful and attractive approach in modern antimicrobial therapy with very promising results including overcoming microbial drug resistance. The emphasis of this review is to notify the scientific community about the latest recent advances from the last five years in the field of hybrid azine derivatives with antimicrobial activity. The review is divided according to the main series of six-member ring azaheterocycles with one nitrogen atom and their fused analogs. In each case, the main essential data concerning synthesis and antimicrobial activity are presented.
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spelling pubmed-96104182022-10-28 Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy Amariucai-Mantu, Dorina Mangalagiu, Violeta Bejan, Iustinian Aricu, Aculina Mangalagiu, Ionel I. Pharmaceutics Review Nowadays, infectious diseases caused by microorganisms are a major threat to human health, mostly because of drug resistance, multi-drug resistance and extensive-drug-resistance phenomena to microbial pathogens. During the last few years, obtaining hybrid azaheterocyclic drugs represents a powerful and attractive approach in modern antimicrobial therapy with very promising results including overcoming microbial drug resistance. The emphasis of this review is to notify the scientific community about the latest recent advances from the last five years in the field of hybrid azine derivatives with antimicrobial activity. The review is divided according to the main series of six-member ring azaheterocycles with one nitrogen atom and their fused analogs. In each case, the main essential data concerning synthesis and antimicrobial activity are presented. MDPI 2022-09-23 /pmc/articles/PMC9610418/ /pubmed/36297461 http://dx.doi.org/10.3390/pharmaceutics14102026 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Amariucai-Mantu, Dorina
Mangalagiu, Violeta
Bejan, Iustinian
Aricu, Aculina
Mangalagiu, Ionel I.
Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy
title Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy
title_full Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy
title_fullStr Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy
title_full_unstemmed Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy
title_short Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy
title_sort hybrid azine derivatives: a useful approach for antimicrobial therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610418/
https://www.ncbi.nlm.nih.gov/pubmed/36297461
http://dx.doi.org/10.3390/pharmaceutics14102026
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