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Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District
The Siberian Federal District is among the most affected regions with a high prevalence of HIV-infection and is characterized by high HIV-infection incidence rate and high mortality among the HIV-infected population. HIV drug resistance poses a major threat to public health and is associated with in...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610422/ https://www.ncbi.nlm.nih.gov/pubmed/36298672 http://dx.doi.org/10.3390/v14102117 |
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author | Shtrek, Sergey Levakhina, Lidiya Blokh, Aleksey Pasechnik, Oksana Pen’evskaya, Nataliya |
author_facet | Shtrek, Sergey Levakhina, Lidiya Blokh, Aleksey Pasechnik, Oksana Pen’evskaya, Nataliya |
author_sort | Shtrek, Sergey |
collection | PubMed |
description | The Siberian Federal District is among the most affected regions with a high prevalence of HIV-infection and is characterized by high HIV-infection incidence rate and high mortality among the HIV-infected population. HIV drug resistance poses a major threat to public health and is associated with increased mortality, HIV incidence, and cost of epidemic control programs. A total of 1281 samples from HIV-infected patients were sequenced and analyzed with the DEONA and HIVdb Program to assess the prevalence of drug resistance mutations in patients in the Siberian Federal District in 2016–2018. The federal surveillance data obtained from 0.5% of HIV-infected patients during the long-term follow-up care in 2021 were also used. The incidence rate of HIV infection in the Siberian Federal District has declined since 2016: from 135.8 per 100 thousand population to 81.1 per 100 thousand population in 2021. Mutations associated with resistance to NRTI and NNRTI were found in 10.3% of the samples in 2016–2018 and in 28.4% of the samples in 2020. The rising prevalence of drug resistance in HIV-infected patients indicates that it is increasingly important to continuously monitor and improve the approaches to the use of effective treatment regimens. |
format | Online Article Text |
id | pubmed-9610422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96104222022-10-28 Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District Shtrek, Sergey Levakhina, Lidiya Blokh, Aleksey Pasechnik, Oksana Pen’evskaya, Nataliya Viruses Article The Siberian Federal District is among the most affected regions with a high prevalence of HIV-infection and is characterized by high HIV-infection incidence rate and high mortality among the HIV-infected population. HIV drug resistance poses a major threat to public health and is associated with increased mortality, HIV incidence, and cost of epidemic control programs. A total of 1281 samples from HIV-infected patients were sequenced and analyzed with the DEONA and HIVdb Program to assess the prevalence of drug resistance mutations in patients in the Siberian Federal District in 2016–2018. The federal surveillance data obtained from 0.5% of HIV-infected patients during the long-term follow-up care in 2021 were also used. The incidence rate of HIV infection in the Siberian Federal District has declined since 2016: from 135.8 per 100 thousand population to 81.1 per 100 thousand population in 2021. Mutations associated with resistance to NRTI and NNRTI were found in 10.3% of the samples in 2016–2018 and in 28.4% of the samples in 2020. The rising prevalence of drug resistance in HIV-infected patients indicates that it is increasingly important to continuously monitor and improve the approaches to the use of effective treatment regimens. MDPI 2022-09-25 /pmc/articles/PMC9610422/ /pubmed/36298672 http://dx.doi.org/10.3390/v14102117 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shtrek, Sergey Levakhina, Lidiya Blokh, Aleksey Pasechnik, Oksana Pen’evskaya, Nataliya Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District |
title | Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District |
title_full | Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District |
title_fullStr | Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District |
title_full_unstemmed | Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District |
title_short | Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District |
title_sort | prevalence and spectrum of hiv-1 resistance mutations in the siberian federal district |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610422/ https://www.ncbi.nlm.nih.gov/pubmed/36298672 http://dx.doi.org/10.3390/v14102117 |
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