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Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District

The Siberian Federal District is among the most affected regions with a high prevalence of HIV-infection and is characterized by high HIV-infection incidence rate and high mortality among the HIV-infected population. HIV drug resistance poses a major threat to public health and is associated with in...

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Autores principales: Shtrek, Sergey, Levakhina, Lidiya, Blokh, Aleksey, Pasechnik, Oksana, Pen’evskaya, Nataliya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610422/
https://www.ncbi.nlm.nih.gov/pubmed/36298672
http://dx.doi.org/10.3390/v14102117
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author Shtrek, Sergey
Levakhina, Lidiya
Blokh, Aleksey
Pasechnik, Oksana
Pen’evskaya, Nataliya
author_facet Shtrek, Sergey
Levakhina, Lidiya
Blokh, Aleksey
Pasechnik, Oksana
Pen’evskaya, Nataliya
author_sort Shtrek, Sergey
collection PubMed
description The Siberian Federal District is among the most affected regions with a high prevalence of HIV-infection and is characterized by high HIV-infection incidence rate and high mortality among the HIV-infected population. HIV drug resistance poses a major threat to public health and is associated with increased mortality, HIV incidence, and cost of epidemic control programs. A total of 1281 samples from HIV-infected patients were sequenced and analyzed with the DEONA and HIVdb Program to assess the prevalence of drug resistance mutations in patients in the Siberian Federal District in 2016–2018. The federal surveillance data obtained from 0.5% of HIV-infected patients during the long-term follow-up care in 2021 were also used. The incidence rate of HIV infection in the Siberian Federal District has declined since 2016: from 135.8 per 100 thousand population to 81.1 per 100 thousand population in 2021. Mutations associated with resistance to NRTI and NNRTI were found in 10.3% of the samples in 2016–2018 and in 28.4% of the samples in 2020. The rising prevalence of drug resistance in HIV-infected patients indicates that it is increasingly important to continuously monitor and improve the approaches to the use of effective treatment regimens.
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spelling pubmed-96104222022-10-28 Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District Shtrek, Sergey Levakhina, Lidiya Blokh, Aleksey Pasechnik, Oksana Pen’evskaya, Nataliya Viruses Article The Siberian Federal District is among the most affected regions with a high prevalence of HIV-infection and is characterized by high HIV-infection incidence rate and high mortality among the HIV-infected population. HIV drug resistance poses a major threat to public health and is associated with increased mortality, HIV incidence, and cost of epidemic control programs. A total of 1281 samples from HIV-infected patients were sequenced and analyzed with the DEONA and HIVdb Program to assess the prevalence of drug resistance mutations in patients in the Siberian Federal District in 2016–2018. The federal surveillance data obtained from 0.5% of HIV-infected patients during the long-term follow-up care in 2021 were also used. The incidence rate of HIV infection in the Siberian Federal District has declined since 2016: from 135.8 per 100 thousand population to 81.1 per 100 thousand population in 2021. Mutations associated with resistance to NRTI and NNRTI were found in 10.3% of the samples in 2016–2018 and in 28.4% of the samples in 2020. The rising prevalence of drug resistance in HIV-infected patients indicates that it is increasingly important to continuously monitor and improve the approaches to the use of effective treatment regimens. MDPI 2022-09-25 /pmc/articles/PMC9610422/ /pubmed/36298672 http://dx.doi.org/10.3390/v14102117 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shtrek, Sergey
Levakhina, Lidiya
Blokh, Aleksey
Pasechnik, Oksana
Pen’evskaya, Nataliya
Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District
title Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District
title_full Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District
title_fullStr Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District
title_full_unstemmed Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District
title_short Prevalence and Spectrum of HIV-1 Resistance Mutations in the Siberian Federal District
title_sort prevalence and spectrum of hiv-1 resistance mutations in the siberian federal district
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610422/
https://www.ncbi.nlm.nih.gov/pubmed/36298672
http://dx.doi.org/10.3390/v14102117
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