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De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases

Background and Objectives: Solid-organ transplant recipients (SOTRs) are notably considered at risk for developing cutaneous malignancies. However, most of the existing literature is focused on kidney transplant-related non-melanoma skin cancers (NMSCs). Conflicting data have been published so far o...

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Autores principales: Paganelli, Alessia, Magistri, Paolo, Kaleci, Shaniko, Chester, Johanna, Pezzini, Claudia, Catellani, Barbara, Ciardo, Silvana, Casari, Alice, Giusti, Francesca, Bassoli, Sara, Di Sandro, Stefano, Pellacani, Giovanni, Farnetani, Francesca, Di Benedetto, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610576/
https://www.ncbi.nlm.nih.gov/pubmed/36295604
http://dx.doi.org/10.3390/medicina58101444
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author Paganelli, Alessia
Magistri, Paolo
Kaleci, Shaniko
Chester, Johanna
Pezzini, Claudia
Catellani, Barbara
Ciardo, Silvana
Casari, Alice
Giusti, Francesca
Bassoli, Sara
Di Sandro, Stefano
Pellacani, Giovanni
Farnetani, Francesca
Di Benedetto, Fabrizio
author_facet Paganelli, Alessia
Magistri, Paolo
Kaleci, Shaniko
Chester, Johanna
Pezzini, Claudia
Catellani, Barbara
Ciardo, Silvana
Casari, Alice
Giusti, Francesca
Bassoli, Sara
Di Sandro, Stefano
Pellacani, Giovanni
Farnetani, Francesca
Di Benedetto, Fabrizio
author_sort Paganelli, Alessia
collection PubMed
description Background and Objectives: Solid-organ transplant recipients (SOTRs) are notably considered at risk for developing cutaneous malignancies. However, most of the existing literature is focused on kidney transplant-related non-melanoma skin cancers (NMSCs). Conflicting data have been published so far on NMSC incidence among liver transplant recipients (LTRs), and whether LTRs really should be considered at lower risk remains controversial. The aim of the present study was to prospectively collect data on the incidence of cutaneous neoplasms in an LTR cohort. Materials and Methods: All LTRs transplanted at the Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit of Modena University Hospital from October 2015 to June 2021 underwent a post-transplant periodic skin check at the Dermatology Unit according to our institutional integrated care pathway. Data on the presence of cutaneous malignant and premalignant lesions were collected at every timepoint. Results: A total of 105 patients were enrolled in the present study. Nearly 15% of the patients developed cutaneous cancerous and/or precancerous lesions during the follow-up period. Almost half of the skin cancerous lesions were basal cell carcinomas. Actinic keratoses (AKs) were observed in six patients. Four patients developed in situ squamous cell carcinomas, and one patient was diagnosed with stage I malignant melanoma. Otherwise, well-established risk factors for the occurrence of skin tumors, such as skin phototype, cumulative sun exposure, and familial history of cutaneous neoplasms, seemed to have no direct impact on skin cancer occurrence in our cohort, as well as an immunosuppressive regimen and the occurrence of non-cutaneous neoplasms. Conclusions: Close dermatological follow-up is crucial for LTRs, and shared protocols of regular skin checks in this particular subset of patients are needed in transplant centers.
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spelling pubmed-96105762022-10-28 De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases Paganelli, Alessia Magistri, Paolo Kaleci, Shaniko Chester, Johanna Pezzini, Claudia Catellani, Barbara Ciardo, Silvana Casari, Alice Giusti, Francesca Bassoli, Sara Di Sandro, Stefano Pellacani, Giovanni Farnetani, Francesca Di Benedetto, Fabrizio Medicina (Kaunas) Communication Background and Objectives: Solid-organ transplant recipients (SOTRs) are notably considered at risk for developing cutaneous malignancies. However, most of the existing literature is focused on kidney transplant-related non-melanoma skin cancers (NMSCs). Conflicting data have been published so far on NMSC incidence among liver transplant recipients (LTRs), and whether LTRs really should be considered at lower risk remains controversial. The aim of the present study was to prospectively collect data on the incidence of cutaneous neoplasms in an LTR cohort. Materials and Methods: All LTRs transplanted at the Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit of Modena University Hospital from October 2015 to June 2021 underwent a post-transplant periodic skin check at the Dermatology Unit according to our institutional integrated care pathway. Data on the presence of cutaneous malignant and premalignant lesions were collected at every timepoint. Results: A total of 105 patients were enrolled in the present study. Nearly 15% of the patients developed cutaneous cancerous and/or precancerous lesions during the follow-up period. Almost half of the skin cancerous lesions were basal cell carcinomas. Actinic keratoses (AKs) were observed in six patients. Four patients developed in situ squamous cell carcinomas, and one patient was diagnosed with stage I malignant melanoma. Otherwise, well-established risk factors for the occurrence of skin tumors, such as skin phototype, cumulative sun exposure, and familial history of cutaneous neoplasms, seemed to have no direct impact on skin cancer occurrence in our cohort, as well as an immunosuppressive regimen and the occurrence of non-cutaneous neoplasms. Conclusions: Close dermatological follow-up is crucial for LTRs, and shared protocols of regular skin checks in this particular subset of patients are needed in transplant centers. MDPI 2022-10-13 /pmc/articles/PMC9610576/ /pubmed/36295604 http://dx.doi.org/10.3390/medicina58101444 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Paganelli, Alessia
Magistri, Paolo
Kaleci, Shaniko
Chester, Johanna
Pezzini, Claudia
Catellani, Barbara
Ciardo, Silvana
Casari, Alice
Giusti, Francesca
Bassoli, Sara
Di Sandro, Stefano
Pellacani, Giovanni
Farnetani, Francesca
Di Benedetto, Fabrizio
De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases
title De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases
title_full De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases
title_fullStr De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases
title_full_unstemmed De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases
title_short De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases
title_sort de novo skin neoplasms in liver-transplanted patients: single-center prospective evaluation of 105 cases
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610576/
https://www.ncbi.nlm.nih.gov/pubmed/36295604
http://dx.doi.org/10.3390/medicina58101444
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