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De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases
Background and Objectives: Solid-organ transplant recipients (SOTRs) are notably considered at risk for developing cutaneous malignancies. However, most of the existing literature is focused on kidney transplant-related non-melanoma skin cancers (NMSCs). Conflicting data have been published so far o...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610576/ https://www.ncbi.nlm.nih.gov/pubmed/36295604 http://dx.doi.org/10.3390/medicina58101444 |
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author | Paganelli, Alessia Magistri, Paolo Kaleci, Shaniko Chester, Johanna Pezzini, Claudia Catellani, Barbara Ciardo, Silvana Casari, Alice Giusti, Francesca Bassoli, Sara Di Sandro, Stefano Pellacani, Giovanni Farnetani, Francesca Di Benedetto, Fabrizio |
author_facet | Paganelli, Alessia Magistri, Paolo Kaleci, Shaniko Chester, Johanna Pezzini, Claudia Catellani, Barbara Ciardo, Silvana Casari, Alice Giusti, Francesca Bassoli, Sara Di Sandro, Stefano Pellacani, Giovanni Farnetani, Francesca Di Benedetto, Fabrizio |
author_sort | Paganelli, Alessia |
collection | PubMed |
description | Background and Objectives: Solid-organ transplant recipients (SOTRs) are notably considered at risk for developing cutaneous malignancies. However, most of the existing literature is focused on kidney transplant-related non-melanoma skin cancers (NMSCs). Conflicting data have been published so far on NMSC incidence among liver transplant recipients (LTRs), and whether LTRs really should be considered at lower risk remains controversial. The aim of the present study was to prospectively collect data on the incidence of cutaneous neoplasms in an LTR cohort. Materials and Methods: All LTRs transplanted at the Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit of Modena University Hospital from October 2015 to June 2021 underwent a post-transplant periodic skin check at the Dermatology Unit according to our institutional integrated care pathway. Data on the presence of cutaneous malignant and premalignant lesions were collected at every timepoint. Results: A total of 105 patients were enrolled in the present study. Nearly 15% of the patients developed cutaneous cancerous and/or precancerous lesions during the follow-up period. Almost half of the skin cancerous lesions were basal cell carcinomas. Actinic keratoses (AKs) were observed in six patients. Four patients developed in situ squamous cell carcinomas, and one patient was diagnosed with stage I malignant melanoma. Otherwise, well-established risk factors for the occurrence of skin tumors, such as skin phototype, cumulative sun exposure, and familial history of cutaneous neoplasms, seemed to have no direct impact on skin cancer occurrence in our cohort, as well as an immunosuppressive regimen and the occurrence of non-cutaneous neoplasms. Conclusions: Close dermatological follow-up is crucial for LTRs, and shared protocols of regular skin checks in this particular subset of patients are needed in transplant centers. |
format | Online Article Text |
id | pubmed-9610576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96105762022-10-28 De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases Paganelli, Alessia Magistri, Paolo Kaleci, Shaniko Chester, Johanna Pezzini, Claudia Catellani, Barbara Ciardo, Silvana Casari, Alice Giusti, Francesca Bassoli, Sara Di Sandro, Stefano Pellacani, Giovanni Farnetani, Francesca Di Benedetto, Fabrizio Medicina (Kaunas) Communication Background and Objectives: Solid-organ transplant recipients (SOTRs) are notably considered at risk for developing cutaneous malignancies. However, most of the existing literature is focused on kidney transplant-related non-melanoma skin cancers (NMSCs). Conflicting data have been published so far on NMSC incidence among liver transplant recipients (LTRs), and whether LTRs really should be considered at lower risk remains controversial. The aim of the present study was to prospectively collect data on the incidence of cutaneous neoplasms in an LTR cohort. Materials and Methods: All LTRs transplanted at the Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit of Modena University Hospital from October 2015 to June 2021 underwent a post-transplant periodic skin check at the Dermatology Unit according to our institutional integrated care pathway. Data on the presence of cutaneous malignant and premalignant lesions were collected at every timepoint. Results: A total of 105 patients were enrolled in the present study. Nearly 15% of the patients developed cutaneous cancerous and/or precancerous lesions during the follow-up period. Almost half of the skin cancerous lesions were basal cell carcinomas. Actinic keratoses (AKs) were observed in six patients. Four patients developed in situ squamous cell carcinomas, and one patient was diagnosed with stage I malignant melanoma. Otherwise, well-established risk factors for the occurrence of skin tumors, such as skin phototype, cumulative sun exposure, and familial history of cutaneous neoplasms, seemed to have no direct impact on skin cancer occurrence in our cohort, as well as an immunosuppressive regimen and the occurrence of non-cutaneous neoplasms. Conclusions: Close dermatological follow-up is crucial for LTRs, and shared protocols of regular skin checks in this particular subset of patients are needed in transplant centers. MDPI 2022-10-13 /pmc/articles/PMC9610576/ /pubmed/36295604 http://dx.doi.org/10.3390/medicina58101444 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Paganelli, Alessia Magistri, Paolo Kaleci, Shaniko Chester, Johanna Pezzini, Claudia Catellani, Barbara Ciardo, Silvana Casari, Alice Giusti, Francesca Bassoli, Sara Di Sandro, Stefano Pellacani, Giovanni Farnetani, Francesca Di Benedetto, Fabrizio De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases |
title | De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases |
title_full | De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases |
title_fullStr | De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases |
title_full_unstemmed | De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases |
title_short | De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases |
title_sort | de novo skin neoplasms in liver-transplanted patients: single-center prospective evaluation of 105 cases |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610576/ https://www.ncbi.nlm.nih.gov/pubmed/36295604 http://dx.doi.org/10.3390/medicina58101444 |
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