Cargando…

Chimeric Virus-like Particles Co-Displaying Hemagglutinin Stem and the C-Terminal Fragment of DnaK Confer Heterologous Influenza Protection in Mice

Influenza virus hemagglutinin (HA) stem is currently regarded as an extremely promising immunogen for designing universal influenza vaccines. The appropriate antigen-presenting vaccine vector would be conducive to increasing the immunogenicity of the HA stem antigen. In this study, we generated chim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Cui-Cui, Liu, De-Jian, Yue, Xin-Yu, Zhong, Xiu-Qin, Wu, Xuan, Chang, Hai-Yan, Wang, Bao-Zhong, Wan, Mu-Yang, Deng, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610613/ https://www.ncbi.nlm.nih.gov/pubmed/36298664 http://dx.doi.org/10.3390/v14102109

Ejemplares similares

Heterologous transmembrane and cytoplasmic domains direct functional chimeric influenza virus hemagglutinins into the endocytic pathway
Publicado: (1986)

Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate
por: Tran, Erin E. H., et al.
Publicado: (2016)

Globular Head-Displayed Conserved Influenza H1 Hemagglutinin Stalk Epitopes Confer Protection against Heterologous H1N1 Virus
por: Klausberger, Miriam, et al.
Publicado: (2016)

Chimeric recombinant rotavirus-like particles as a vehicle for the display of heterologous epitopes
por: Peralta, Andrea, et al.
Publicado: (2009)

Dual-linker gold nanoparticles as adjuvanting carriers for multivalent display of recombinant influenza hemagglutinin trimers and flagellin improve the immunological responses in vivo and in vitro
por: Wang, Chao, et al.
Publicado: (2017)

Influenza chimeric hemagglutinin structures in complex with broadly protective antibodies to the stem and trimer interface
por: Zhu, Xueyong, et al.
Publicado: (2022)

Chimeric Hemagglutinin-Based Live-Attenuated Vaccines Confer Durable Protective Immunity against Influenza A Viruses in a Preclinical Ferret Model
por: Liu, Wen-Chun, et al.
Publicado: (2021)

Enhanced Immunogenicity of Stabilized Trimeric Soluble Influenza Hemagglutinin
por: Weldon, William C., et al.
Publicado: (2010)

Baculovirus Displaying Hemagglutinin Elicits Broad Cross-Protection against Influenza in Mice
por: Sim, Sang-Hee, et al.
Publicado: (2016)

Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model
por: Liu, Wen-Chun, et al.
Publicado: (2019)

Advancing usability of an influenza hemagglutinin virus-like particle vaccine expressing a chimeric cytokine
por: Imagawa, Toshifumi, et al.
Publicado: (2023)

Bioprocess development for universal influenza vaccines based on inactivated split chimeric and mosaic hemagglutinin viruses
por: Puente-Massaguer, Eduard, et al.
Publicado: (2023)

Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccines
por: Sutton, Troy C., et al.
Publicado: (2017)

Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts
por: Shvartsman, Dmitry E., et al.
Publicado: (2003)

Recombinant hemagglutinin displaying on yeast reshapes congenital lymphocyte subsets to prompt optimized systemic immune protection against avian influenza infection
por: Zhang, Han, et al.
Publicado: (2023)

Reinkarnál dnak a részecskegyorsít k
Publicado: (2009)

Endocytosis of chimeric influenza virus hemagglutinin proteins that lack a cytoplasmic recognition feature for coated pits
Publicado: (1996)

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses
por: Kanekiyo, Masaru, et al.
Publicado: (2019)

Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens
por: Kar, Uddipan, et al.
Publicado: (2022)

Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry
por: Du, Ruikun, et al.
Publicado: (2019)

Vaccination With Viral Vectors Expressing Chimeric Hemagglutinin, NP and M1 Antigens Protects Ferrets Against Influenza Virus Challenge
por: McMahon, Meagan, et al.
Publicado: (2019)

Influenza Chimeric Protein (3M2e-3HA2-NP) Adjuvanted with PGA/Alum Confers Cross-Protection against Heterologous Influenza A Viruses
por: Kwak, Chaewon, et al.
Publicado: (2021)

Development of an mRNA vaccine against a panel of heterologous H1N1 seasonal influenza viruses using a consensus hemagglutinin sequence
por: Ma, Ning, et al.
Publicado: (2023)

Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin
por: Park, Bo Ryoung, et al.
Publicado: (2021)

The large external domain is sufficient for the correct sorting of secreted or chimeric influenza virus hemagglutinins in polarized monkey kidney cells
Publicado: (1987)

Influenza hemagglutinin membrane anchor
por: Benton, Donald J., et al.
Publicado: (2018)

Intranasal Immunization of Baculovirus Displayed Hemagglutinin Confers Complete Protection against Mouse Adapted Highly Pathogenic H7N7 Reassortant Influenza Virus
por: Rajesh Kumar, Subaschandrabose, et al.
Publicado: (2013)

DnaK-Dependent Accelerated Evolutionary Rate in Prokaryotes
por: Kadibalban, A. Samer, et al.
Publicado: (2016)

Role of Mycoplasma Chaperone DnaK in Cellular Transformation
por: Benedetti, Francesca, et al.
Publicado: (2020)

Vaccination against Influenza with Recombinant Hemagglutinin Expressed by Schizochytrium sp. Confers Protective Immunity
por: Bayne, Anne-Cécile V., et al.
Publicado: (2013)

Chimeric hemagglutinin split vaccines elicit broadly cross-reactive antibodies and protection against group 2 influenza viruses in mice
por: Puente-Massaguer, Eduard, et al.
Publicado: (2023)

Antibody-Dependent Cell-Mediated Cytotoxicity to Hemagglutinin of Influenza A Viruses After Influenza Vaccination in Humans
por: Zhong, Weimin, et al.
Publicado: (2016)

Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket
por: Leu, Julia I-Ju, et al.
Publicado: (2014)

Folding of influenza hemagglutinin in the endoplasmic reticulum
Publicado: (1991)

Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins
por: Gamblin, Steven J., et al.
Publicado: (2010)

Influenza A Virus Entry Inhibitors Targeting the Hemagglutinin
por: Yang, Jie, et al.
Publicado: (2013)

Vaccination with viral vectors expressing NP, M1 and chimeric hemagglutinin induces broad protection against influenza virus challenge in mice
por: Asthagiri Arunkumar, Guha, et al.
Publicado: (2019)

Novel pH Selective, Highly Lytic Peptides Based on a Chimeric Influenza Hemagglutinin Peptide/Cell Penetrating Peptide Motif
por: Algayer, Bethany, et al.
Publicado: (2019)

Influence of Escherichia coli chaperone DnaK on protein immunogenicity
por: Ratanji, Kirsty D., et al.
Publicado: (2016)

The force-dependent mechanism of DnaK-mediated mechanical folding
por: Perales-Calvo, Judit, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gl8f0ropspb67qvvei4o0mn3or