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Effect of Vitamin D on Bone Regeneration: A Review

Background and Objectives: Vitamin D (Vit. D) is known for its role in the skeletal system. Vit. D deficiency is also widely researched for its effects on the healing of fractures, bone defects, and osseointegration of implants. In the literature, there are studies that investigated the effects of d...

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Autores principales: Muresan, Giorgiana Corina, Hedesiu, Mihaela, Lucaciu, Ondine, Boca, Sanda, Petrescu, Nausica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610653/
https://www.ncbi.nlm.nih.gov/pubmed/36295498
http://dx.doi.org/10.3390/medicina58101337
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author Muresan, Giorgiana Corina
Hedesiu, Mihaela
Lucaciu, Ondine
Boca, Sanda
Petrescu, Nausica
author_facet Muresan, Giorgiana Corina
Hedesiu, Mihaela
Lucaciu, Ondine
Boca, Sanda
Petrescu, Nausica
author_sort Muresan, Giorgiana Corina
collection PubMed
description Background and Objectives: Vitamin D (Vit. D) is known for its role in the skeletal system. Vit. D deficiency is also widely researched for its effects on the healing of fractures, bone defects, and osseointegration of implants. In the literature, there are studies that investigated the effects of dietary supplementation with Vit. D to reduce Vit. D deficiency, but increasing the serum level of this vitamin takes time. Therefore, an attempt has been made to combat the effect of Vit. D deficiency through topical applications. The aim of this article was to conduct a review of the existing bibliographic data that investigate the effect of Vit. D on bone regeneration. Materials and Methods: In order to carry out this review, an electronic search was made in several databases and the articles found were selected and analyzed. Results: The in vitro studies’ results demonstrated that Vit. D has a high therapeutic potential by enhancing the differentiation of stem cells in osteoblasts. Human and animal studies were conducting using various methods, but most of them revealed that Vit. D has a positive influence on the process of bone regeneration. Conclusions: The overall results of the research showed that, indeed, Vit. D is beneficial for bone regeneration; however, most of the studies imply that a thorough research is still needed for finding the most effective mode of administration and the dose needed in order to achieve the desired effect.
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spelling pubmed-96106532022-10-28 Effect of Vitamin D on Bone Regeneration: A Review Muresan, Giorgiana Corina Hedesiu, Mihaela Lucaciu, Ondine Boca, Sanda Petrescu, Nausica Medicina (Kaunas) Review Background and Objectives: Vitamin D (Vit. D) is known for its role in the skeletal system. Vit. D deficiency is also widely researched for its effects on the healing of fractures, bone defects, and osseointegration of implants. In the literature, there are studies that investigated the effects of dietary supplementation with Vit. D to reduce Vit. D deficiency, but increasing the serum level of this vitamin takes time. Therefore, an attempt has been made to combat the effect of Vit. D deficiency through topical applications. The aim of this article was to conduct a review of the existing bibliographic data that investigate the effect of Vit. D on bone regeneration. Materials and Methods: In order to carry out this review, an electronic search was made in several databases and the articles found were selected and analyzed. Results: The in vitro studies’ results demonstrated that Vit. D has a high therapeutic potential by enhancing the differentiation of stem cells in osteoblasts. Human and animal studies were conducting using various methods, but most of them revealed that Vit. D has a positive influence on the process of bone regeneration. Conclusions: The overall results of the research showed that, indeed, Vit. D is beneficial for bone regeneration; however, most of the studies imply that a thorough research is still needed for finding the most effective mode of administration and the dose needed in order to achieve the desired effect. MDPI 2022-09-23 /pmc/articles/PMC9610653/ /pubmed/36295498 http://dx.doi.org/10.3390/medicina58101337 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Muresan, Giorgiana Corina
Hedesiu, Mihaela
Lucaciu, Ondine
Boca, Sanda
Petrescu, Nausica
Effect of Vitamin D on Bone Regeneration: A Review
title Effect of Vitamin D on Bone Regeneration: A Review
title_full Effect of Vitamin D on Bone Regeneration: A Review
title_fullStr Effect of Vitamin D on Bone Regeneration: A Review
title_full_unstemmed Effect of Vitamin D on Bone Regeneration: A Review
title_short Effect of Vitamin D on Bone Regeneration: A Review
title_sort effect of vitamin d on bone regeneration: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610653/
https://www.ncbi.nlm.nih.gov/pubmed/36295498
http://dx.doi.org/10.3390/medicina58101337
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