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Impact of Guidelines Regarding Dihydropyrimidine Dehydrogenase (DPD) Deficiency Screening Using Uracil-Based Phenotyping on the Reduction of Severe Side Effect of 5-Fluorouracil-Based Chemotherapy: A Propension Score Analysis

Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with severe fluoropyrimidines-induced toxicity. As of September 2018, French recommendations call for screening for DPD deficiency by plasma uracil quantification prior to all fluoropyrimidine-based chemotherapy. A dose reduction of fluo...

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Detalles Bibliográficos
Autores principales:	Laures, Nicolas, Konecki, Céline, Brugel, Mathias, Giffard, Anne-Lise, Abdelli, Naceur, Botsen, Damien, Carlier, Claire, Gozalo, Claire, Feliu, Catherine, Slimano, Florian, Djerada, Zoubir, Bouché, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610761/ https://www.ncbi.nlm.nih.gov/pubmed/36297556 http://dx.doi.org/10.3390/pharmaceutics14102119

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