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Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease

Sickle cell disease (SCD) is caused by a single-point mutation, and the ensuing deoxygenation-induced polymerization of sickle hemoglobin (HbS), and reduction in bioavailability of vascular nitric oxide (NO), contribute to the pathogenesis of the disease. In a proof-of-concept study, we successfully...

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Detalles Bibliográficos
Autores principales:	Huang, Boshi, Ghatge, Mohini S., Donkor, Akua K., Musayev, Faik N., Deshpande, Tanvi M., Al-Awadh, Mohammed, Alhashimi, Rana T., Zhu, Hongmei, Omar, Abdelsattar M., Telen, Marilyn J., Zhang, Yan, McMahon, Tim J., Abdulmalik, Osheiza, Safo, Martin K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610770/ https://www.ncbi.nlm.nih.gov/pubmed/36296435 http://dx.doi.org/10.3390/molecules27206835

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