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Mechanical Cardiac Support With an Implantable Direct Cardiac Compression Device: Proof of Concept

PURPOSE: We examined the hemodynamic effects of a new, implantable, direct cardiac assist device in an ovine heart failure model. DESCRIPTION: The device, which encompasses both left and right ventricles, is inserted through the pericardial apex and self-expands to encompass the heart without suturi...

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Autores principales: Letsou, George V., Bolch, Christina M., Hord, Erica C., Altman, William C., Youngblood, Brad L., Leschinsky, Boris, Criscione, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610996/
https://www.ncbi.nlm.nih.gov/pubmed/35921854
http://dx.doi.org/10.1016/j.athoracsur.2022.06.052
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author Letsou, George V.
Bolch, Christina M.
Hord, Erica C.
Altman, William C.
Youngblood, Brad L.
Leschinsky, Boris
Criscione, John C.
author_facet Letsou, George V.
Bolch, Christina M.
Hord, Erica C.
Altman, William C.
Youngblood, Brad L.
Leschinsky, Boris
Criscione, John C.
author_sort Letsou, George V.
collection PubMed
description PURPOSE: We examined the hemodynamic effects of a new, implantable, direct cardiac assist device in an ovine heart failure model. DESCRIPTION: The device, which encompasses both left and right ventricles, is inserted through the pericardial apex and self-expands to encompass the heart without suturing. The intact pericardium anchors the device in place. The device has 2 concentric chamber layers: an internal chamber layer filled with fluid to conform to the heart and an external chamber layer filled with air that provides external compression and negative pressure to aid relaxation. EVALUATION: The device was implanted in 7 sheep with heart failure induced by microsphere embolization. Cardiac performance was assessed for 6 to 8 hours. The cardiac assist device provided cardiac systolic and diastolic assistance, as shown by pressure tracings of the left ventricle and aorta, pulmonary artery flow, and +dP/dt. Central venous pressure decreased during cardiac assistance. No anatomic damage was noted postmortem. CONCLUSIONS: Systolic and diastolic cardiac assistance can be achieved with this device that compresses and relaxes in synchrony with the native cardiac cycle.
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spelling pubmed-96109962022-11-01 Mechanical Cardiac Support With an Implantable Direct Cardiac Compression Device: Proof of Concept Letsou, George V. Bolch, Christina M. Hord, Erica C. Altman, William C. Youngblood, Brad L. Leschinsky, Boris Criscione, John C. Ann Thorac Surg New Technology PURPOSE: We examined the hemodynamic effects of a new, implantable, direct cardiac assist device in an ovine heart failure model. DESCRIPTION: The device, which encompasses both left and right ventricles, is inserted through the pericardial apex and self-expands to encompass the heart without suturing. The intact pericardium anchors the device in place. The device has 2 concentric chamber layers: an internal chamber layer filled with fluid to conform to the heart and an external chamber layer filled with air that provides external compression and negative pressure to aid relaxation. EVALUATION: The device was implanted in 7 sheep with heart failure induced by microsphere embolization. Cardiac performance was assessed for 6 to 8 hours. The cardiac assist device provided cardiac systolic and diastolic assistance, as shown by pressure tracings of the left ventricle and aorta, pulmonary artery flow, and +dP/dt. Central venous pressure decreased during cardiac assistance. No anatomic damage was noted postmortem. CONCLUSIONS: Systolic and diastolic cardiac assistance can be achieved with this device that compresses and relaxes in synchrony with the native cardiac cycle. Elsevier 2022-11 /pmc/articles/PMC9610996/ /pubmed/35921854 http://dx.doi.org/10.1016/j.athoracsur.2022.06.052 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle New Technology
Letsou, George V.
Bolch, Christina M.
Hord, Erica C.
Altman, William C.
Youngblood, Brad L.
Leschinsky, Boris
Criscione, John C.
Mechanical Cardiac Support With an Implantable Direct Cardiac Compression Device: Proof of Concept
title Mechanical Cardiac Support With an Implantable Direct Cardiac Compression Device: Proof of Concept
title_full Mechanical Cardiac Support With an Implantable Direct Cardiac Compression Device: Proof of Concept
title_fullStr Mechanical Cardiac Support With an Implantable Direct Cardiac Compression Device: Proof of Concept
title_full_unstemmed Mechanical Cardiac Support With an Implantable Direct Cardiac Compression Device: Proof of Concept
title_short Mechanical Cardiac Support With an Implantable Direct Cardiac Compression Device: Proof of Concept
title_sort mechanical cardiac support with an implantable direct cardiac compression device: proof of concept
topic New Technology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610996/
https://www.ncbi.nlm.nih.gov/pubmed/35921854
http://dx.doi.org/10.1016/j.athoracsur.2022.06.052
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