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Systemic Endothelial Function, Plasma Xanthine Oxidoreductase Activity, and Blood Pressure Variability in Patients with Stable Coronary Artery Disease

Background and Objectives: Although previous studies showed that an activity of xanthine oxidoreductase (XOR), a rate-limiting enzyme in purine metabolism, beyond the serum uric acid level, was associated with the development of coronary artery disease (CAD), the underlying mechanisms are unclear. B...

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Autores principales: Hiraga, Takashi, Saito, Yuichi, Tateishi, Kazuya, Mori, Naoto, Murase, Takayo, Nakamura, Takashi, Akari, Seigo, Saito, Kan, Kitahara, Hideki, Kobayashi, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611040/
https://www.ncbi.nlm.nih.gov/pubmed/36295583
http://dx.doi.org/10.3390/medicina58101423
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author Hiraga, Takashi
Saito, Yuichi
Tateishi, Kazuya
Mori, Naoto
Murase, Takayo
Nakamura, Takashi
Akari, Seigo
Saito, Kan
Kitahara, Hideki
Kobayashi, Yoshio
author_facet Hiraga, Takashi
Saito, Yuichi
Tateishi, Kazuya
Mori, Naoto
Murase, Takayo
Nakamura, Takashi
Akari, Seigo
Saito, Kan
Kitahara, Hideki
Kobayashi, Yoshio
author_sort Hiraga, Takashi
collection PubMed
description Background and Objectives: Although previous studies showed that an activity of xanthine oxidoreductase (XOR), a rate-limiting enzyme in purine metabolism, beyond the serum uric acid level, was associated with the development of coronary artery disease (CAD), the underlying mechanisms are unclear. Because endothelial dysfunction and a greater blood pressure (BP) variability may play a role, we investigated the relations among the endothelial function, XOR, and BP variability. Materials and Methods: This was a post-hoc study using pooled data of patients with a stable CAD from two prospective investigations, in which the systemic endothelial function was assessed with the reactive hyperemia index (RHI) and the XOR activity was measured. The BP variability was evaluated using BP measurements during the three- and four-day hospitalization. Results: A total of 106 patients with a stable CAD undergoing a percutaneous coronary intervention were included. Of the 106 patients, 46 (43.4%) had a systemic endothelial dysfunction (RHI < 1.67). The multivariable analysis identified a higher body mass index (BMI), female gender, and diabetes as factors associated with an endothelial dysfunction. A higher BMI was also related to an elevated XOR activity, in addition to current smoking. No significant correlation was observed between the RHI and XOR activity. Similarly, the in-hospital BP variability was associated with neither the endothelial function nor XOR. Conclusions: Among patients with a stable CAD, several factors were identified as being associated with a systemic endothelial dysfunction or an elevated XOR activity. However, no direct relations between the endothelial function, XOR, and BP variability were found.
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spelling pubmed-96110402022-10-28 Systemic Endothelial Function, Plasma Xanthine Oxidoreductase Activity, and Blood Pressure Variability in Patients with Stable Coronary Artery Disease Hiraga, Takashi Saito, Yuichi Tateishi, Kazuya Mori, Naoto Murase, Takayo Nakamura, Takashi Akari, Seigo Saito, Kan Kitahara, Hideki Kobayashi, Yoshio Medicina (Kaunas) Article Background and Objectives: Although previous studies showed that an activity of xanthine oxidoreductase (XOR), a rate-limiting enzyme in purine metabolism, beyond the serum uric acid level, was associated with the development of coronary artery disease (CAD), the underlying mechanisms are unclear. Because endothelial dysfunction and a greater blood pressure (BP) variability may play a role, we investigated the relations among the endothelial function, XOR, and BP variability. Materials and Methods: This was a post-hoc study using pooled data of patients with a stable CAD from two prospective investigations, in which the systemic endothelial function was assessed with the reactive hyperemia index (RHI) and the XOR activity was measured. The BP variability was evaluated using BP measurements during the three- and four-day hospitalization. Results: A total of 106 patients with a stable CAD undergoing a percutaneous coronary intervention were included. Of the 106 patients, 46 (43.4%) had a systemic endothelial dysfunction (RHI < 1.67). The multivariable analysis identified a higher body mass index (BMI), female gender, and diabetes as factors associated with an endothelial dysfunction. A higher BMI was also related to an elevated XOR activity, in addition to current smoking. No significant correlation was observed between the RHI and XOR activity. Similarly, the in-hospital BP variability was associated with neither the endothelial function nor XOR. Conclusions: Among patients with a stable CAD, several factors were identified as being associated with a systemic endothelial dysfunction or an elevated XOR activity. However, no direct relations between the endothelial function, XOR, and BP variability were found. MDPI 2022-10-10 /pmc/articles/PMC9611040/ /pubmed/36295583 http://dx.doi.org/10.3390/medicina58101423 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hiraga, Takashi
Saito, Yuichi
Tateishi, Kazuya
Mori, Naoto
Murase, Takayo
Nakamura, Takashi
Akari, Seigo
Saito, Kan
Kitahara, Hideki
Kobayashi, Yoshio
Systemic Endothelial Function, Plasma Xanthine Oxidoreductase Activity, and Blood Pressure Variability in Patients with Stable Coronary Artery Disease
title Systemic Endothelial Function, Plasma Xanthine Oxidoreductase Activity, and Blood Pressure Variability in Patients with Stable Coronary Artery Disease
title_full Systemic Endothelial Function, Plasma Xanthine Oxidoreductase Activity, and Blood Pressure Variability in Patients with Stable Coronary Artery Disease
title_fullStr Systemic Endothelial Function, Plasma Xanthine Oxidoreductase Activity, and Blood Pressure Variability in Patients with Stable Coronary Artery Disease
title_full_unstemmed Systemic Endothelial Function, Plasma Xanthine Oxidoreductase Activity, and Blood Pressure Variability in Patients with Stable Coronary Artery Disease
title_short Systemic Endothelial Function, Plasma Xanthine Oxidoreductase Activity, and Blood Pressure Variability in Patients with Stable Coronary Artery Disease
title_sort systemic endothelial function, plasma xanthine oxidoreductase activity, and blood pressure variability in patients with stable coronary artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611040/
https://www.ncbi.nlm.nih.gov/pubmed/36295583
http://dx.doi.org/10.3390/medicina58101423
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