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Domino Aza-Michael-S(N)Ar-Heteroaromatization Route to C5-Substituted 1-Alkyl-1H-Indole-3-Carboxylic Esters

A new synthesis of C5-substituted 1-alkyl-1H-indole-3-carboxylic esters is reported. A series of methyl 2-arylacrylate aza-Michael acceptors were prepared with aromatic substitution to activate them towards S(N)Ar reaction. Subsequent reaction with a series of primary amines generated the title comp...

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Detalles Bibliográficos
Autores principales:	Ametsetor, Ebenezer, Farthing, Spencer, Bunce, Richard A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611145/ https://www.ncbi.nlm.nih.gov/pubmed/36296590 http://dx.doi.org/10.3390/molecules27206998

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