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Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions
Droplet sorting is one of the fundamental manipulations of droplet-based microfluidics. Although many sorting methods have already been proposed, there is still a demand to develop new sorting methods for various applications of droplet-based microfluidics. This work presents numerical investigation...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611150/ https://www.ncbi.nlm.nih.gov/pubmed/36295993 http://dx.doi.org/10.3390/mi13101640 |
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author | Yang, He Knowles, Tuomas P. J. |
author_facet | Yang, He Knowles, Tuomas P. J. |
author_sort | Yang, He |
collection | PubMed |
description | Droplet sorting is one of the fundamental manipulations of droplet-based microfluidics. Although many sorting methods have already been proposed, there is still a demand to develop new sorting methods for various applications of droplet-based microfluidics. This work presents numerical investigations on droplet sorting with asymmetric acute junctions. It is found that the asymmetric acute junctions could achieve volume-based sorting and velocity-based sorting. The pressure distributions in the asymmetric junctions are discussed to reveal the physical mechanism behind the droplet sorting. The dependence of the droplet sorting on the droplet volume, velocity, and junction angle is explored. The possibility of the employment of the proposed sorting method in most real experiments is also discussed. This work provides a new, simple, and cost-effective passive strategy to separate droplets in microfluidic channels. Moreover, the proposed acute junctions could be used in combination with other sorting methods, which may boost more opportunities to sort droplets. |
format | Online Article Text |
id | pubmed-9611150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96111502022-10-28 Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions Yang, He Knowles, Tuomas P. J. Micromachines (Basel) Article Droplet sorting is one of the fundamental manipulations of droplet-based microfluidics. Although many sorting methods have already been proposed, there is still a demand to develop new sorting methods for various applications of droplet-based microfluidics. This work presents numerical investigations on droplet sorting with asymmetric acute junctions. It is found that the asymmetric acute junctions could achieve volume-based sorting and velocity-based sorting. The pressure distributions in the asymmetric junctions are discussed to reveal the physical mechanism behind the droplet sorting. The dependence of the droplet sorting on the droplet volume, velocity, and junction angle is explored. The possibility of the employment of the proposed sorting method in most real experiments is also discussed. This work provides a new, simple, and cost-effective passive strategy to separate droplets in microfluidic channels. Moreover, the proposed acute junctions could be used in combination with other sorting methods, which may boost more opportunities to sort droplets. MDPI 2022-09-29 /pmc/articles/PMC9611150/ /pubmed/36295993 http://dx.doi.org/10.3390/mi13101640 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yang, He Knowles, Tuomas P. J. Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions |
title | Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions |
title_full | Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions |
title_fullStr | Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions |
title_full_unstemmed | Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions |
title_short | Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions |
title_sort | hydrodynamics of droplet sorting in asymmetric acute junctions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611150/ https://www.ncbi.nlm.nih.gov/pubmed/36295993 http://dx.doi.org/10.3390/mi13101640 |
work_keys_str_mv | AT yanghe hydrodynamicsofdropletsortinginasymmetricacutejunctions AT knowlestuomaspj hydrodynamicsofdropletsortinginasymmetricacutejunctions |