Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic Acid

The use of crystal engineering to convert liquids into crystalline solids remains a powerful method for inhibiting undesired degradation pathways. When nicotine, a liquid sensitive to both light and air, is combined with the GRAS-listed compound, gentisic acid, the resulting crystalline solid, exhib...

Descripción completa

Detalles Bibliográficos
Autores principales: Angevine, Devin J., Camacho, Kristine Joy, Rzayev, Javid, Benedict, Jason B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611154/
https://www.ncbi.nlm.nih.gov/pubmed/36296448
http://dx.doi.org/10.3390/molecules27206853
_version_ 1784819455629459456
author Angevine, Devin J.
Camacho, Kristine Joy
Rzayev, Javid
Benedict, Jason B.
author_facet Angevine, Devin J.
Camacho, Kristine Joy
Rzayev, Javid
Benedict, Jason B.
author_sort Angevine, Devin J.
collection PubMed
description The use of crystal engineering to convert liquids into crystalline solids remains a powerful method for inhibiting undesired degradation pathways. When nicotine, a liquid sensitive to both light and air, is combined with the GRAS-listed compound, gentisic acid, the resulting crystalline solid, exhibits enhanced photo and thermal stability. Despite a modest ΔT(m) of 42.7 °C, the melting point of 155.9 °C for the nicotinium gentisate salt is the highest reported for nicotine-containing crystalline solids. An analysis of the crystal packing and thermodynamic properties provides context for the observed properties.
format Online
Article
Text
id pubmed-9611154
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96111542022-10-28 Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic Acid Angevine, Devin J. Camacho, Kristine Joy Rzayev, Javid Benedict, Jason B. Molecules Article The use of crystal engineering to convert liquids into crystalline solids remains a powerful method for inhibiting undesired degradation pathways. When nicotine, a liquid sensitive to both light and air, is combined with the GRAS-listed compound, gentisic acid, the resulting crystalline solid, exhibits enhanced photo and thermal stability. Despite a modest ΔT(m) of 42.7 °C, the melting point of 155.9 °C for the nicotinium gentisate salt is the highest reported for nicotine-containing crystalline solids. An analysis of the crystal packing and thermodynamic properties provides context for the observed properties. MDPI 2022-10-13 /pmc/articles/PMC9611154/ /pubmed/36296448 http://dx.doi.org/10.3390/molecules27206853 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Angevine, Devin J.
Camacho, Kristine Joy
Rzayev, Javid
Benedict, Jason B.
Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic Acid
title Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic Acid
title_full Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic Acid
title_fullStr Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic Acid
title_full_unstemmed Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic Acid
title_short Enhancing the Photo and Thermal Stability of Nicotine through Crystal Engineering with Gentisic Acid
title_sort enhancing the photo and thermal stability of nicotine through crystal engineering with gentisic acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611154/
https://www.ncbi.nlm.nih.gov/pubmed/36296448
http://dx.doi.org/10.3390/molecules27206853
work_keys_str_mv AT angevinedevinj enhancingthephotoandthermalstabilityofnicotinethroughcrystalengineeringwithgentisicacid
AT camachokristinejoy enhancingthephotoandthermalstabilityofnicotinethroughcrystalengineeringwithgentisicacid
AT rzayevjavid enhancingthephotoandthermalstabilityofnicotinethroughcrystalengineeringwithgentisicacid
AT benedictjasonb enhancingthephotoandthermalstabilityofnicotinethroughcrystalengineeringwithgentisicacid

Ejemplares similares