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MicroRNA and Metabolic Profiling of a Primary Ovarian Neuroendocrine Carcinoma Pulmonary-Type Reveals a High Degree of Similarity with Small Cell Lung Cancer

Small cell neuroendocrine carcinoma is most frequently found in the lung (SCLC), but it has been also reported, albeit with a very low incidence, in the ovary. Here, we analyze a case of primary small cell carcinoma of the ovary of pulmonary type (SCCOPT), a rare and aggressive tumor with poor progn...

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Autores principales: Miglietta, Stefano, Girolimetti, Giulia, Marchio, Lorena, Sollazzo, Manuela, Laprovitera, Noemi, Coluccelli, Sara, De Biase, Dario, De Leo, Antonio, Santini, Donatella, Kurelac, Ivana, Iommarini, Luisa, Ghelli, Anna, Campana, Davide, Ferracin, Manuela, Perrone, Anna Myriam, Gasparre, Giuseppe, Porcelli, Anna Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611163/
https://www.ncbi.nlm.nih.gov/pubmed/36287116
http://dx.doi.org/10.3390/ncrna8050064
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author Miglietta, Stefano
Girolimetti, Giulia
Marchio, Lorena
Sollazzo, Manuela
Laprovitera, Noemi
Coluccelli, Sara
De Biase, Dario
De Leo, Antonio
Santini, Donatella
Kurelac, Ivana
Iommarini, Luisa
Ghelli, Anna
Campana, Davide
Ferracin, Manuela
Perrone, Anna Myriam
Gasparre, Giuseppe
Porcelli, Anna Maria
author_facet Miglietta, Stefano
Girolimetti, Giulia
Marchio, Lorena
Sollazzo, Manuela
Laprovitera, Noemi
Coluccelli, Sara
De Biase, Dario
De Leo, Antonio
Santini, Donatella
Kurelac, Ivana
Iommarini, Luisa
Ghelli, Anna
Campana, Davide
Ferracin, Manuela
Perrone, Anna Myriam
Gasparre, Giuseppe
Porcelli, Anna Maria
author_sort Miglietta, Stefano
collection PubMed
description Small cell neuroendocrine carcinoma is most frequently found in the lung (SCLC), but it has been also reported, albeit with a very low incidence, in the ovary. Here, we analyze a case of primary small cell carcinoma of the ovary of pulmonary type (SCCOPT), a rare and aggressive tumor with poor prognosis, whose biology and molecular features have not yet been thoroughly investigated. The patient affected by SCCOPT had a residual tumor following chemotherapy which displayed pronounced similarity with neuroendocrine tumors and lung cancer in terms of its microRNA expression profile and mTOR-downstream activation. By analyzing the metabolic markers of the neoplastic lesion, we established a likely glycolytic signature. In conclusion, this in-depth characterization of SCCOPT could be useful for future diagnoses, possibly aided by microRNA profiling, allowing clinicians to adopt the most appropriate therapeutic strategy.
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spelling pubmed-96111632022-10-28 MicroRNA and Metabolic Profiling of a Primary Ovarian Neuroendocrine Carcinoma Pulmonary-Type Reveals a High Degree of Similarity with Small Cell Lung Cancer Miglietta, Stefano Girolimetti, Giulia Marchio, Lorena Sollazzo, Manuela Laprovitera, Noemi Coluccelli, Sara De Biase, Dario De Leo, Antonio Santini, Donatella Kurelac, Ivana Iommarini, Luisa Ghelli, Anna Campana, Davide Ferracin, Manuela Perrone, Anna Myriam Gasparre, Giuseppe Porcelli, Anna Maria Noncoding RNA Article Small cell neuroendocrine carcinoma is most frequently found in the lung (SCLC), but it has been also reported, albeit with a very low incidence, in the ovary. Here, we analyze a case of primary small cell carcinoma of the ovary of pulmonary type (SCCOPT), a rare and aggressive tumor with poor prognosis, whose biology and molecular features have not yet been thoroughly investigated. The patient affected by SCCOPT had a residual tumor following chemotherapy which displayed pronounced similarity with neuroendocrine tumors and lung cancer in terms of its microRNA expression profile and mTOR-downstream activation. By analyzing the metabolic markers of the neoplastic lesion, we established a likely glycolytic signature. In conclusion, this in-depth characterization of SCCOPT could be useful for future diagnoses, possibly aided by microRNA profiling, allowing clinicians to adopt the most appropriate therapeutic strategy. MDPI 2022-09-25 /pmc/articles/PMC9611163/ /pubmed/36287116 http://dx.doi.org/10.3390/ncrna8050064 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Miglietta, Stefano
Girolimetti, Giulia
Marchio, Lorena
Sollazzo, Manuela
Laprovitera, Noemi
Coluccelli, Sara
De Biase, Dario
De Leo, Antonio
Santini, Donatella
Kurelac, Ivana
Iommarini, Luisa
Ghelli, Anna
Campana, Davide
Ferracin, Manuela
Perrone, Anna Myriam
Gasparre, Giuseppe
Porcelli, Anna Maria
MicroRNA and Metabolic Profiling of a Primary Ovarian Neuroendocrine Carcinoma Pulmonary-Type Reveals a High Degree of Similarity with Small Cell Lung Cancer
title MicroRNA and Metabolic Profiling of a Primary Ovarian Neuroendocrine Carcinoma Pulmonary-Type Reveals a High Degree of Similarity with Small Cell Lung Cancer
title_full MicroRNA and Metabolic Profiling of a Primary Ovarian Neuroendocrine Carcinoma Pulmonary-Type Reveals a High Degree of Similarity with Small Cell Lung Cancer
title_fullStr MicroRNA and Metabolic Profiling of a Primary Ovarian Neuroendocrine Carcinoma Pulmonary-Type Reveals a High Degree of Similarity with Small Cell Lung Cancer
title_full_unstemmed MicroRNA and Metabolic Profiling of a Primary Ovarian Neuroendocrine Carcinoma Pulmonary-Type Reveals a High Degree of Similarity with Small Cell Lung Cancer
title_short MicroRNA and Metabolic Profiling of a Primary Ovarian Neuroendocrine Carcinoma Pulmonary-Type Reveals a High Degree of Similarity with Small Cell Lung Cancer
title_sort microrna and metabolic profiling of a primary ovarian neuroendocrine carcinoma pulmonary-type reveals a high degree of similarity with small cell lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611163/
https://www.ncbi.nlm.nih.gov/pubmed/36287116
http://dx.doi.org/10.3390/ncrna8050064
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