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Case report: Local bleomycin injection: A possible treatment option for primitive myxoid mesenchymal tumor of infancy

In recent years, it has been determined that primitive myxoid mesenchymal tumors of infancy (PMMTI) are solid tumors. To date, very few cases of PMMTI have been reported, and there is no consensus regarding treatment. To provide additional references, it is necessary to collect and report the diagno...

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Autores principales: Yang, Binbin, Chen, Qingjiang, Zhu, Yueling, Wang, Jianbing, Dong, Ao, Chen, Yi, He, Xue, Gu, Weizhong, Gao, Zhigang, Qian, Yunzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611196/
https://www.ncbi.nlm.nih.gov/pubmed/36313882
http://dx.doi.org/10.3389/fped.2022.993450
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author Yang, Binbin
Chen, Qingjiang
Zhu, Yueling
Wang, Jianbing
Dong, Ao
Chen, Yi
He, Xue
Gu, Weizhong
Gao, Zhigang
Qian, Yunzhong
author_facet Yang, Binbin
Chen, Qingjiang
Zhu, Yueling
Wang, Jianbing
Dong, Ao
Chen, Yi
He, Xue
Gu, Weizhong
Gao, Zhigang
Qian, Yunzhong
author_sort Yang, Binbin
collection PubMed
description In recent years, it has been determined that primitive myxoid mesenchymal tumors of infancy (PMMTI) are solid tumors. To date, very few cases of PMMTI have been reported, and there is no consensus regarding treatment. To provide additional references, it is necessary to collect and report the diagnoses and treatment outcomes of related cases. We report the case of a 38-day-old girl who presented with a 5-cm purple tumor in the right shoulder. Upon hospital admission, the patient received an intratumoral injection of bleomycin after diagnosis of a possible lymphangioma. 10 days after the treatment, the tumor began to develop inflammation and necrosis, resulting in a clear demarcation between the tumor and surrounding tissue. Hence, during the second hospitalization, we performed a successful tumor resection. Postoperatively, the tumor was pathologically diagnosed as PMMTI. 3 months after excision, the patient showed no local recurrence on re-examination. To the best of our knowledge, this is the first report of a PMMTI in which bleomycin, or other similar chemotherapeutic drugs, have been injected into tumors. This result offers novel insights into the treatment of PMMTI. Injection therapy with bleomycin and similar chemotherapeutics may result in specific responses to PMMTI, which may help in developing better surgical conditions or improving outcomes in non-surgical patients.
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spelling pubmed-96111962022-10-28 Case report: Local bleomycin injection: A possible treatment option for primitive myxoid mesenchymal tumor of infancy Yang, Binbin Chen, Qingjiang Zhu, Yueling Wang, Jianbing Dong, Ao Chen, Yi He, Xue Gu, Weizhong Gao, Zhigang Qian, Yunzhong Front Pediatr Pediatrics In recent years, it has been determined that primitive myxoid mesenchymal tumors of infancy (PMMTI) are solid tumors. To date, very few cases of PMMTI have been reported, and there is no consensus regarding treatment. To provide additional references, it is necessary to collect and report the diagnoses and treatment outcomes of related cases. We report the case of a 38-day-old girl who presented with a 5-cm purple tumor in the right shoulder. Upon hospital admission, the patient received an intratumoral injection of bleomycin after diagnosis of a possible lymphangioma. 10 days after the treatment, the tumor began to develop inflammation and necrosis, resulting in a clear demarcation between the tumor and surrounding tissue. Hence, during the second hospitalization, we performed a successful tumor resection. Postoperatively, the tumor was pathologically diagnosed as PMMTI. 3 months after excision, the patient showed no local recurrence on re-examination. To the best of our knowledge, this is the first report of a PMMTI in which bleomycin, or other similar chemotherapeutic drugs, have been injected into tumors. This result offers novel insights into the treatment of PMMTI. Injection therapy with bleomycin and similar chemotherapeutics may result in specific responses to PMMTI, which may help in developing better surgical conditions or improving outcomes in non-surgical patients. Frontiers Media S.A. 2022-10-11 /pmc/articles/PMC9611196/ /pubmed/36313882 http://dx.doi.org/10.3389/fped.2022.993450 Text en Copyright © 2022 Yang, Chen, Zhu, Wang, Dong, Chen, He, Gu, Gao and Qian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Yang, Binbin
Chen, Qingjiang
Zhu, Yueling
Wang, Jianbing
Dong, Ao
Chen, Yi
He, Xue
Gu, Weizhong
Gao, Zhigang
Qian, Yunzhong
Case report: Local bleomycin injection: A possible treatment option for primitive myxoid mesenchymal tumor of infancy
title Case report: Local bleomycin injection: A possible treatment option for primitive myxoid mesenchymal tumor of infancy
title_full Case report: Local bleomycin injection: A possible treatment option for primitive myxoid mesenchymal tumor of infancy
title_fullStr Case report: Local bleomycin injection: A possible treatment option for primitive myxoid mesenchymal tumor of infancy
title_full_unstemmed Case report: Local bleomycin injection: A possible treatment option for primitive myxoid mesenchymal tumor of infancy
title_short Case report: Local bleomycin injection: A possible treatment option for primitive myxoid mesenchymal tumor of infancy
title_sort case report: local bleomycin injection: a possible treatment option for primitive myxoid mesenchymal tumor of infancy
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611196/
https://www.ncbi.nlm.nih.gov/pubmed/36313882
http://dx.doi.org/10.3389/fped.2022.993450
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