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Additive Manufacturing of Drug-Eluting Multilayer Biodegradable Films

Drug-eluting films made of bioresorbable polymers are a widely used tool of modern personalized medicine. However, most currently existing methods of producing coatings do not go beyond the laboratory, as they have low encapsulation efficiency and/or difficulties in scaling up. The PLACE (Printed La...

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Detalles Bibliográficos
Autores principales: Proshin, Pavel I., Abdurashitov, Arkady S., Sindeeva, Olga A., Ivanova, Anastasia A., Sukhorukov, Gleb B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611279/
https://www.ncbi.nlm.nih.gov/pubmed/36297899
http://dx.doi.org/10.3390/polym14204318
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author Proshin, Pavel I.
Abdurashitov, Arkady S.
Sindeeva, Olga A.
Ivanova, Anastasia A.
Sukhorukov, Gleb B.
author_facet Proshin, Pavel I.
Abdurashitov, Arkady S.
Sindeeva, Olga A.
Ivanova, Anastasia A.
Sukhorukov, Gleb B.
author_sort Proshin, Pavel I.
collection PubMed
description Drug-eluting films made of bioresorbable polymers are a widely used tool of modern personalized medicine. However, most currently existing methods of producing coatings do not go beyond the laboratory, as they have low encapsulation efficiency and/or difficulties in scaling up. The PLACE (Printed Layered Adjustable Cargo Encapsulation) technology proposed in this article uses an additive approach for film manufacturing. PLACE technology is accessible, scalable, and reproducible in any laboratory. As a demonstration of the technology capabilities, we fabricated layered drug-eluting polyglycolic acid films containing different concentrations of Cefazolin antibiotic. The influence of the amount of loaded drug component on the film production process and the release kinetics was studied. The specific loading of drugs was significantly increased to 200–400 µg/cm(2) while maintaining the uniform release of Cefazolin antibiotic in a dosage sufficient for local antimicrobial therapy for 14 days. The fact that the further increase in the drug amount results in the crystallization of a substance, which can lead to specific defects in the cover film formation and accelerated one-week cargo release, was also shown, and options for further technology development were proposed.
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spelling pubmed-96112792022-10-28 Additive Manufacturing of Drug-Eluting Multilayer Biodegradable Films Proshin, Pavel I. Abdurashitov, Arkady S. Sindeeva, Olga A. Ivanova, Anastasia A. Sukhorukov, Gleb B. Polymers (Basel) Article Drug-eluting films made of bioresorbable polymers are a widely used tool of modern personalized medicine. However, most currently existing methods of producing coatings do not go beyond the laboratory, as they have low encapsulation efficiency and/or difficulties in scaling up. The PLACE (Printed Layered Adjustable Cargo Encapsulation) technology proposed in this article uses an additive approach for film manufacturing. PLACE technology is accessible, scalable, and reproducible in any laboratory. As a demonstration of the technology capabilities, we fabricated layered drug-eluting polyglycolic acid films containing different concentrations of Cefazolin antibiotic. The influence of the amount of loaded drug component on the film production process and the release kinetics was studied. The specific loading of drugs was significantly increased to 200–400 µg/cm(2) while maintaining the uniform release of Cefazolin antibiotic in a dosage sufficient for local antimicrobial therapy for 14 days. The fact that the further increase in the drug amount results in the crystallization of a substance, which can lead to specific defects in the cover film formation and accelerated one-week cargo release, was also shown, and options for further technology development were proposed. MDPI 2022-10-14 /pmc/articles/PMC9611279/ /pubmed/36297899 http://dx.doi.org/10.3390/polym14204318 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Proshin, Pavel I.
Abdurashitov, Arkady S.
Sindeeva, Olga A.
Ivanova, Anastasia A.
Sukhorukov, Gleb B.
Additive Manufacturing of Drug-Eluting Multilayer Biodegradable Films
title Additive Manufacturing of Drug-Eluting Multilayer Biodegradable Films
title_full Additive Manufacturing of Drug-Eluting Multilayer Biodegradable Films
title_fullStr Additive Manufacturing of Drug-Eluting Multilayer Biodegradable Films
title_full_unstemmed Additive Manufacturing of Drug-Eluting Multilayer Biodegradable Films
title_short Additive Manufacturing of Drug-Eluting Multilayer Biodegradable Films
title_sort additive manufacturing of drug-eluting multilayer biodegradable films
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611279/
https://www.ncbi.nlm.nih.gov/pubmed/36297899
http://dx.doi.org/10.3390/polym14204318
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