Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients

Hepatitis E virus (HEV) is the most prevalent hepatitis virus worldwide. Genotypes 3 (HEV3) and 4 (HEV4) as well as rat HEV can lead to chronic hepatitis E and cirrhosis in immunosuppressed patients. Within the last decade, several options for treating chronic hepatitis have been developed and have...

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Autores principales: Kamar, Nassim, Del Bello, Arnaud, Abravanel, Florence, Pan, Qiuwei, Izopet, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611326/
https://www.ncbi.nlm.nih.gov/pubmed/36298671
http://dx.doi.org/10.3390/v14102116
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author Kamar, Nassim
Del Bello, Arnaud
Abravanel, Florence
Pan, Qiuwei
Izopet, Jacques
author_facet Kamar, Nassim
Del Bello, Arnaud
Abravanel, Florence
Pan, Qiuwei
Izopet, Jacques
author_sort Kamar, Nassim
collection PubMed
description Hepatitis E virus (HEV) is the most prevalent hepatitis virus worldwide. Genotypes 3 (HEV3) and 4 (HEV4) as well as rat HEV can lead to chronic hepatitis E and cirrhosis in immunosuppressed patients. Within the last decade, several options for treating chronic hepatitis have been developed and have achieved a sustained virological response. However, there are still unmet needs such as optimizing immunosuppression to allow HEV clearance with or without ribavirin, as well as alternative therapies to ribavirin that are discussed in this paper.
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spelling pubmed-96113262022-10-28 Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients Kamar, Nassim Del Bello, Arnaud Abravanel, Florence Pan, Qiuwei Izopet, Jacques Viruses Perspective Hepatitis E virus (HEV) is the most prevalent hepatitis virus worldwide. Genotypes 3 (HEV3) and 4 (HEV4) as well as rat HEV can lead to chronic hepatitis E and cirrhosis in immunosuppressed patients. Within the last decade, several options for treating chronic hepatitis have been developed and have achieved a sustained virological response. However, there are still unmet needs such as optimizing immunosuppression to allow HEV clearance with or without ribavirin, as well as alternative therapies to ribavirin that are discussed in this paper. MDPI 2022-09-25 /pmc/articles/PMC9611326/ /pubmed/36298671 http://dx.doi.org/10.3390/v14102116 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Kamar, Nassim
Del Bello, Arnaud
Abravanel, Florence
Pan, Qiuwei
Izopet, Jacques
Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients
title Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients
title_full Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients
title_fullStr Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients
title_full_unstemmed Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients
title_short Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients
title_sort unmet needs for the treatment of chronic hepatitis e virus infection in immunocompromised patients
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611326/
https://www.ncbi.nlm.nih.gov/pubmed/36298671
http://dx.doi.org/10.3390/v14102116
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