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Lower Rate of Water Absorption of an Oral Rehydration Solution with Partially Hydrolyzed Guar Gum in Conscious Rats

The purpose of the present study was to elucidate the rate of water absorption of an oral rehydration solution containing partially hydrolyzed guar gum (PHGG) in the small intestine, which is the main site of water absorption when water is drunk. Seven-week-old male SD rats were employed. We prepare...

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Autores principales: Takahashi, Toru, Tokunaga, Miki, Okubo, Tsutomu, Ozeki, Makoto, Kapoor, Mahendra P., Yasukawa, Zenta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611419/
https://www.ncbi.nlm.nih.gov/pubmed/36296915
http://dx.doi.org/10.3390/nu14204231
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author Takahashi, Toru
Tokunaga, Miki
Okubo, Tsutomu
Ozeki, Makoto
Kapoor, Mahendra P.
Yasukawa, Zenta
author_facet Takahashi, Toru
Tokunaga, Miki
Okubo, Tsutomu
Ozeki, Makoto
Kapoor, Mahendra P.
Yasukawa, Zenta
author_sort Takahashi, Toru
collection PubMed
description The purpose of the present study was to elucidate the rate of water absorption of an oral rehydration solution containing partially hydrolyzed guar gum (PHGG) in the small intestine, which is the main site of water absorption when water is drunk. Seven-week-old male SD rats were employed. We prepared four types of an aqueous solution, i.e., containing mineral and sugar, containing PHGG, containing mineral and sugar and PHGG, or containing no additives. After 24 h of food and 4 h of water deprivation, the aqueous solutions were infused into the stomach of conscious rats on their hands using a syringe with a stomach sonde. We sampled the stomach and the small intestine with contents 8 min after the infusions. Causal effects were calculated using a Bayesian network. PHGG increased the residual amount of water in the gastro-intestine, which depends negatively on the absorption of water in the small intestine/the flow rate to the small intestine. The absorption of water in the small intestine depended positively on the flow rate to the small intestine, which depended negatively on the free water in the solutions. PHGG decreased water absorption in the small intestine by decreasing the free water in the aqueous solutions.
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spelling pubmed-96114192022-10-28 Lower Rate of Water Absorption of an Oral Rehydration Solution with Partially Hydrolyzed Guar Gum in Conscious Rats Takahashi, Toru Tokunaga, Miki Okubo, Tsutomu Ozeki, Makoto Kapoor, Mahendra P. Yasukawa, Zenta Nutrients Article The purpose of the present study was to elucidate the rate of water absorption of an oral rehydration solution containing partially hydrolyzed guar gum (PHGG) in the small intestine, which is the main site of water absorption when water is drunk. Seven-week-old male SD rats were employed. We prepared four types of an aqueous solution, i.e., containing mineral and sugar, containing PHGG, containing mineral and sugar and PHGG, or containing no additives. After 24 h of food and 4 h of water deprivation, the aqueous solutions were infused into the stomach of conscious rats on their hands using a syringe with a stomach sonde. We sampled the stomach and the small intestine with contents 8 min after the infusions. Causal effects were calculated using a Bayesian network. PHGG increased the residual amount of water in the gastro-intestine, which depends negatively on the absorption of water in the small intestine/the flow rate to the small intestine. The absorption of water in the small intestine depended positively on the flow rate to the small intestine, which depended negatively on the free water in the solutions. PHGG decreased water absorption in the small intestine by decreasing the free water in the aqueous solutions. MDPI 2022-10-11 /pmc/articles/PMC9611419/ /pubmed/36296915 http://dx.doi.org/10.3390/nu14204231 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Takahashi, Toru
Tokunaga, Miki
Okubo, Tsutomu
Ozeki, Makoto
Kapoor, Mahendra P.
Yasukawa, Zenta
Lower Rate of Water Absorption of an Oral Rehydration Solution with Partially Hydrolyzed Guar Gum in Conscious Rats
title Lower Rate of Water Absorption of an Oral Rehydration Solution with Partially Hydrolyzed Guar Gum in Conscious Rats
title_full Lower Rate of Water Absorption of an Oral Rehydration Solution with Partially Hydrolyzed Guar Gum in Conscious Rats
title_fullStr Lower Rate of Water Absorption of an Oral Rehydration Solution with Partially Hydrolyzed Guar Gum in Conscious Rats
title_full_unstemmed Lower Rate of Water Absorption of an Oral Rehydration Solution with Partially Hydrolyzed Guar Gum in Conscious Rats
title_short Lower Rate of Water Absorption of an Oral Rehydration Solution with Partially Hydrolyzed Guar Gum in Conscious Rats
title_sort lower rate of water absorption of an oral rehydration solution with partially hydrolyzed guar gum in conscious rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611419/
https://www.ncbi.nlm.nih.gov/pubmed/36296915
http://dx.doi.org/10.3390/nu14204231
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