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Go-Ichi-Ni-San 2: A potential biomarker and therapeutic target in human cancers

Cancer incidence and mortality are increasing globally, leading to its rising status as a leading cause of death. The Go-Ichi-Ni-San (GINS) complex plays a crucial role in DNA replication and the cell cycle. The GINS complex consists of four subunits encoded by the GINS1, GINS2, GINS3, and GINS4 gen...

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Autores principales: Shan, Dan-Dan, Zheng, Qiu-Xian, Chen, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611433/
https://www.ncbi.nlm.nih.gov/pubmed/36310704
http://dx.doi.org/10.4251/wjgo.v14.i10.1892
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author Shan, Dan-Dan
Zheng, Qiu-Xian
Chen, Zhi
author_facet Shan, Dan-Dan
Zheng, Qiu-Xian
Chen, Zhi
author_sort Shan, Dan-Dan
collection PubMed
description Cancer incidence and mortality are increasing globally, leading to its rising status as a leading cause of death. The Go-Ichi-Ni-San (GINS) complex plays a crucial role in DNA replication and the cell cycle. The GINS complex consists of four subunits encoded by the GINS1, GINS2, GINS3, and GINS4 genes. Recent findings have shown that GINS2 expression is upregulated in many diseases, particularly tumors. For example, increased GINS2 expression has been found in cervical cancer, gastric adenocarcinoma, glioma, non-small cell lung cancer, and pancreatic cancer. It correlates with the clinicopathological characteristics of the tumors. In addition, high GINS2 expression plays a pro-carcinogenic role in tumor development by promoting tumor cell proliferation and migration, inhibiting tumor cell apoptosis, and blocking the cell cycle. This review describes the upregulation of GINS2 expression in most human tumors and the pathway of GINS2 in tumor development. GINS2 may serve as a new marker for tumor diagnosis and a new biological target for therapy.
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spelling pubmed-96114332022-10-28 Go-Ichi-Ni-San 2: A potential biomarker and therapeutic target in human cancers Shan, Dan-Dan Zheng, Qiu-Xian Chen, Zhi World J Gastrointest Oncol Minireviews Cancer incidence and mortality are increasing globally, leading to its rising status as a leading cause of death. The Go-Ichi-Ni-San (GINS) complex plays a crucial role in DNA replication and the cell cycle. The GINS complex consists of four subunits encoded by the GINS1, GINS2, GINS3, and GINS4 genes. Recent findings have shown that GINS2 expression is upregulated in many diseases, particularly tumors. For example, increased GINS2 expression has been found in cervical cancer, gastric adenocarcinoma, glioma, non-small cell lung cancer, and pancreatic cancer. It correlates with the clinicopathological characteristics of the tumors. In addition, high GINS2 expression plays a pro-carcinogenic role in tumor development by promoting tumor cell proliferation and migration, inhibiting tumor cell apoptosis, and blocking the cell cycle. This review describes the upregulation of GINS2 expression in most human tumors and the pathway of GINS2 in tumor development. GINS2 may serve as a new marker for tumor diagnosis and a new biological target for therapy. Baishideng Publishing Group Inc 2022-10-15 2022-10-15 /pmc/articles/PMC9611433/ /pubmed/36310704 http://dx.doi.org/10.4251/wjgo.v14.i10.1892 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Minireviews
Shan, Dan-Dan
Zheng, Qiu-Xian
Chen, Zhi
Go-Ichi-Ni-San 2: A potential biomarker and therapeutic target in human cancers
title Go-Ichi-Ni-San 2: A potential biomarker and therapeutic target in human cancers
title_full Go-Ichi-Ni-San 2: A potential biomarker and therapeutic target in human cancers
title_fullStr Go-Ichi-Ni-San 2: A potential biomarker and therapeutic target in human cancers
title_full_unstemmed Go-Ichi-Ni-San 2: A potential biomarker and therapeutic target in human cancers
title_short Go-Ichi-Ni-San 2: A potential biomarker and therapeutic target in human cancers
title_sort go-ichi-ni-san 2: a potential biomarker and therapeutic target in human cancers
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611433/
https://www.ncbi.nlm.nih.gov/pubmed/36310704
http://dx.doi.org/10.4251/wjgo.v14.i10.1892
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