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Comparative Study of Vaccinated and Unvaccinated Hospitalised Patients: A Retrospective Population Study of 500 Hospitalised Patients with SARS-CoV-2 Infection in a Spanish Population of 220,000 Inhabitants

Objectives. This study aimed to compare the characteristics of fully and partially vaccinated or unvaccinated coronavirus disease 2019 (COVID-19) patients who were hospitalised in a population of 220,000 habitants. Methods: Retrospective, observational, and population studies were conducted on patie...

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Autores principales: Ruiz-Giardin, José M., Rivilla, Marta, Mesa, Nieves, Morales, Alejandro, Rivas, Luis, Izquierdo, Aída, Escribá, Almudena, San Martín, Juan V., Bernal-Bello, David, Madroñal, Elena, Farfán, Ana I., Guerrero, Marta, Calderón, Ruth, Duarte, Miguel A., Piedrabuena, Sara I., Toledano-Macías, María, Satué, José Á., Marrero, Jorge, de Ancos, Cristina L., Frutos, Begoña, Cristóbal, Rafael, Soria, Guillermo, Ayala-Larrañaga, Ibone, Carpintero, Lorena, de Hita, Miguel, Lara, Celia, Llerena, Álvaro R., García, Virginia, Jiménez, Raquel, García, Vanesa, Saiz-Lou, Elena M., Prieto, Santiago, González-Pereira, Natalia, Lechuga, Luis Antonio, Tarancón, Jorge, Gonzalo, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611498/
https://www.ncbi.nlm.nih.gov/pubmed/36298839
http://dx.doi.org/10.3390/v14102284
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author Ruiz-Giardin, José M.
Rivilla, Marta
Mesa, Nieves
Morales, Alejandro
Rivas, Luis
Izquierdo, Aída
Escribá, Almudena
San Martín, Juan V.
Bernal-Bello, David
Madroñal, Elena
Farfán, Ana I.
Guerrero, Marta
Calderón, Ruth
Duarte, Miguel A.
Piedrabuena, Sara I.
Toledano-Macías, María
Satué, José Á.
Marrero, Jorge
de Ancos, Cristina L.
Frutos, Begoña
Cristóbal, Rafael
Soria, Guillermo
Ayala-Larrañaga, Ibone
Carpintero, Lorena
de Hita, Miguel
Lara, Celia
Llerena, Álvaro R.
García, Virginia
Jiménez, Raquel
García, Vanesa
Saiz-Lou, Elena M.
Prieto, Santiago
González-Pereira, Natalia
Lechuga, Luis Antonio
Tarancón, Jorge
Gonzalo, Sonia
author_facet Ruiz-Giardin, José M.
Rivilla, Marta
Mesa, Nieves
Morales, Alejandro
Rivas, Luis
Izquierdo, Aída
Escribá, Almudena
San Martín, Juan V.
Bernal-Bello, David
Madroñal, Elena
Farfán, Ana I.
Guerrero, Marta
Calderón, Ruth
Duarte, Miguel A.
Piedrabuena, Sara I.
Toledano-Macías, María
Satué, José Á.
Marrero, Jorge
de Ancos, Cristina L.
Frutos, Begoña
Cristóbal, Rafael
Soria, Guillermo
Ayala-Larrañaga, Ibone
Carpintero, Lorena
de Hita, Miguel
Lara, Celia
Llerena, Álvaro R.
García, Virginia
Jiménez, Raquel
García, Vanesa
Saiz-Lou, Elena M.
Prieto, Santiago
González-Pereira, Natalia
Lechuga, Luis Antonio
Tarancón, Jorge
Gonzalo, Sonia
author_sort Ruiz-Giardin, José M.
collection PubMed
description Objectives. This study aimed to compare the characteristics of fully and partially vaccinated or unvaccinated coronavirus disease 2019 (COVID-19) patients who were hospitalised in a population of 220,000 habitants. Methods: Retrospective, observational, and population studies were conducted on patients who were hospitalised due to COVID-19 from March to October 2021. We assessed the impact of vaccination and other risk factors through Cox multivariate analysis. Results: A total of 500 patients were hospitalised, among whom 77 (15.4%) were fully vaccinated, 86 (17.2%) were partially vaccinated, and 337 (67.4%) were unvaccinated. Fully vaccinated (FV) patients were older and had a higher Charlson index than those of partially vaccinated and unvaccinated patients (NFV). Bilateral pneumonia was more frequent among NFV (259/376 (68.9%)) than among FV patients (32/75 (42.7%)). The former had more intensive care unit admissions (63/423) than the latter (4/77); OR: 2.80; CI (1.07–9.47). Increasing age HZ: 1.1 (1.06–1.14)) and haematological disease at admission HZ: 2.99 (1.26–7.11)) were independent risk factors for higher mortality during the first 30 days of hospitalisation. The probability of an earlier discharge in the subgroup of 440 patients who did not die during the first 30 days of hospitalisation was related to age (older to younger: HZ: 0.98 (0.97–0.99)) and vaccination status. Conclusions: Among the patients hospitalised because of COVID-19, complete vaccination was associated with less severe forms of COVID-19, with an earlier discharge date. Age and haematological disease were related to a higher mortality rate during the first 30 days of hospitalisation.
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spelling pubmed-96114982022-10-28 Comparative Study of Vaccinated and Unvaccinated Hospitalised Patients: A Retrospective Population Study of 500 Hospitalised Patients with SARS-CoV-2 Infection in a Spanish Population of 220,000 Inhabitants Ruiz-Giardin, José M. Rivilla, Marta Mesa, Nieves Morales, Alejandro Rivas, Luis Izquierdo, Aída Escribá, Almudena San Martín, Juan V. Bernal-Bello, David Madroñal, Elena Farfán, Ana I. Guerrero, Marta Calderón, Ruth Duarte, Miguel A. Piedrabuena, Sara I. Toledano-Macías, María Satué, José Á. Marrero, Jorge de Ancos, Cristina L. Frutos, Begoña Cristóbal, Rafael Soria, Guillermo Ayala-Larrañaga, Ibone Carpintero, Lorena de Hita, Miguel Lara, Celia Llerena, Álvaro R. García, Virginia Jiménez, Raquel García, Vanesa Saiz-Lou, Elena M. Prieto, Santiago González-Pereira, Natalia Lechuga, Luis Antonio Tarancón, Jorge Gonzalo, Sonia Viruses Article Objectives. This study aimed to compare the characteristics of fully and partially vaccinated or unvaccinated coronavirus disease 2019 (COVID-19) patients who were hospitalised in a population of 220,000 habitants. Methods: Retrospective, observational, and population studies were conducted on patients who were hospitalised due to COVID-19 from March to October 2021. We assessed the impact of vaccination and other risk factors through Cox multivariate analysis. Results: A total of 500 patients were hospitalised, among whom 77 (15.4%) were fully vaccinated, 86 (17.2%) were partially vaccinated, and 337 (67.4%) were unvaccinated. Fully vaccinated (FV) patients were older and had a higher Charlson index than those of partially vaccinated and unvaccinated patients (NFV). Bilateral pneumonia was more frequent among NFV (259/376 (68.9%)) than among FV patients (32/75 (42.7%)). The former had more intensive care unit admissions (63/423) than the latter (4/77); OR: 2.80; CI (1.07–9.47). Increasing age HZ: 1.1 (1.06–1.14)) and haematological disease at admission HZ: 2.99 (1.26–7.11)) were independent risk factors for higher mortality during the first 30 days of hospitalisation. The probability of an earlier discharge in the subgroup of 440 patients who did not die during the first 30 days of hospitalisation was related to age (older to younger: HZ: 0.98 (0.97–0.99)) and vaccination status. Conclusions: Among the patients hospitalised because of COVID-19, complete vaccination was associated with less severe forms of COVID-19, with an earlier discharge date. Age and haematological disease were related to a higher mortality rate during the first 30 days of hospitalisation. MDPI 2022-10-17 /pmc/articles/PMC9611498/ /pubmed/36298839 http://dx.doi.org/10.3390/v14102284 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ruiz-Giardin, José M.
Rivilla, Marta
Mesa, Nieves
Morales, Alejandro
Rivas, Luis
Izquierdo, Aída
Escribá, Almudena
San Martín, Juan V.
Bernal-Bello, David
Madroñal, Elena
Farfán, Ana I.
Guerrero, Marta
Calderón, Ruth
Duarte, Miguel A.
Piedrabuena, Sara I.
Toledano-Macías, María
Satué, José Á.
Marrero, Jorge
de Ancos, Cristina L.
Frutos, Begoña
Cristóbal, Rafael
Soria, Guillermo
Ayala-Larrañaga, Ibone
Carpintero, Lorena
de Hita, Miguel
Lara, Celia
Llerena, Álvaro R.
García, Virginia
Jiménez, Raquel
García, Vanesa
Saiz-Lou, Elena M.
Prieto, Santiago
González-Pereira, Natalia
Lechuga, Luis Antonio
Tarancón, Jorge
Gonzalo, Sonia
Comparative Study of Vaccinated and Unvaccinated Hospitalised Patients: A Retrospective Population Study of 500 Hospitalised Patients with SARS-CoV-2 Infection in a Spanish Population of 220,000 Inhabitants
title Comparative Study of Vaccinated and Unvaccinated Hospitalised Patients: A Retrospective Population Study of 500 Hospitalised Patients with SARS-CoV-2 Infection in a Spanish Population of 220,000 Inhabitants
title_full Comparative Study of Vaccinated and Unvaccinated Hospitalised Patients: A Retrospective Population Study of 500 Hospitalised Patients with SARS-CoV-2 Infection in a Spanish Population of 220,000 Inhabitants
title_fullStr Comparative Study of Vaccinated and Unvaccinated Hospitalised Patients: A Retrospective Population Study of 500 Hospitalised Patients with SARS-CoV-2 Infection in a Spanish Population of 220,000 Inhabitants
title_full_unstemmed Comparative Study of Vaccinated and Unvaccinated Hospitalised Patients: A Retrospective Population Study of 500 Hospitalised Patients with SARS-CoV-2 Infection in a Spanish Population of 220,000 Inhabitants
title_short Comparative Study of Vaccinated and Unvaccinated Hospitalised Patients: A Retrospective Population Study of 500 Hospitalised Patients with SARS-CoV-2 Infection in a Spanish Population of 220,000 Inhabitants
title_sort comparative study of vaccinated and unvaccinated hospitalised patients: a retrospective population study of 500 hospitalised patients with sars-cov-2 infection in a spanish population of 220,000 inhabitants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611498/
https://www.ncbi.nlm.nih.gov/pubmed/36298839
http://dx.doi.org/10.3390/v14102284
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