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Polyelectrolyte Membrane Nanocoatings Aimed at Personal Protective and Medical Equipment Surfaces to Reduce Coronavirus Spreading

The study of the surface of membrane coatings constructed with adsorbed coronavirus (COV) was described to test their suitability for the antiviral activity for application in personal protective and medical equipment. The nanocoating based on polyethyleneimine (PEI) or polystyrene sulfonate (PSS) w...

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Autores principales: Grzeczkowicz, Anna, Lipko, Agata, Kwiatkowska, Angelika, Strawski, Marcin, Bącal, Paweł, Więckowska, Agnieszka, Granicka, Ludomira H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611533/
https://www.ncbi.nlm.nih.gov/pubmed/36295705
http://dx.doi.org/10.3390/membranes12100946
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author Grzeczkowicz, Anna
Lipko, Agata
Kwiatkowska, Angelika
Strawski, Marcin
Bącal, Paweł
Więckowska, Agnieszka
Granicka, Ludomira H.
author_facet Grzeczkowicz, Anna
Lipko, Agata
Kwiatkowska, Angelika
Strawski, Marcin
Bącal, Paweł
Więckowska, Agnieszka
Granicka, Ludomira H.
author_sort Grzeczkowicz, Anna
collection PubMed
description The study of the surface of membrane coatings constructed with adsorbed coronavirus (COV) was described to test their suitability for the antiviral activity for application in personal protective and medical equipment. The nanocoating based on polyethyleneimine (PEI) or polystyrene sulfonate (PSS) with metallic nanoparticles incorporated was investigated using the AFM technique. Moreover, the functioning of human lung cells in a configuration with the prepared material with the adsorbed coronavirus was studied using microscopic techniques and flow cytometry. The mean values of the percentage share of viable cells compared with the control differed by a maximum of 22%. The results showed that PEI and PSS membrane layer coatings, modified with chosen metallic nanoparticles (AuNPs, AgNPs, CuNPs, FeNPs) that absorb COV, could support lung cells’ function, despite the different distribution patterns of COV on designed surfaces as well as immobilized lung cells. Therefore, the developed membrane nanocoatings can be recommended as material for biomedical applications, e.g., medical equipment surfaces to reduce coronavirus spreading, as they adsorb COV and simultaneously maintain the functioning of the eukaryotic cells.
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spelling pubmed-96115332022-10-28 Polyelectrolyte Membrane Nanocoatings Aimed at Personal Protective and Medical Equipment Surfaces to Reduce Coronavirus Spreading Grzeczkowicz, Anna Lipko, Agata Kwiatkowska, Angelika Strawski, Marcin Bącal, Paweł Więckowska, Agnieszka Granicka, Ludomira H. Membranes (Basel) Article The study of the surface of membrane coatings constructed with adsorbed coronavirus (COV) was described to test their suitability for the antiviral activity for application in personal protective and medical equipment. The nanocoating based on polyethyleneimine (PEI) or polystyrene sulfonate (PSS) with metallic nanoparticles incorporated was investigated using the AFM technique. Moreover, the functioning of human lung cells in a configuration with the prepared material with the adsorbed coronavirus was studied using microscopic techniques and flow cytometry. The mean values of the percentage share of viable cells compared with the control differed by a maximum of 22%. The results showed that PEI and PSS membrane layer coatings, modified with chosen metallic nanoparticles (AuNPs, AgNPs, CuNPs, FeNPs) that absorb COV, could support lung cells’ function, despite the different distribution patterns of COV on designed surfaces as well as immobilized lung cells. Therefore, the developed membrane nanocoatings can be recommended as material for biomedical applications, e.g., medical equipment surfaces to reduce coronavirus spreading, as they adsorb COV and simultaneously maintain the functioning of the eukaryotic cells. MDPI 2022-09-28 /pmc/articles/PMC9611533/ /pubmed/36295705 http://dx.doi.org/10.3390/membranes12100946 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grzeczkowicz, Anna
Lipko, Agata
Kwiatkowska, Angelika
Strawski, Marcin
Bącal, Paweł
Więckowska, Agnieszka
Granicka, Ludomira H.
Polyelectrolyte Membrane Nanocoatings Aimed at Personal Protective and Medical Equipment Surfaces to Reduce Coronavirus Spreading
title Polyelectrolyte Membrane Nanocoatings Aimed at Personal Protective and Medical Equipment Surfaces to Reduce Coronavirus Spreading
title_full Polyelectrolyte Membrane Nanocoatings Aimed at Personal Protective and Medical Equipment Surfaces to Reduce Coronavirus Spreading
title_fullStr Polyelectrolyte Membrane Nanocoatings Aimed at Personal Protective and Medical Equipment Surfaces to Reduce Coronavirus Spreading
title_full_unstemmed Polyelectrolyte Membrane Nanocoatings Aimed at Personal Protective and Medical Equipment Surfaces to Reduce Coronavirus Spreading
title_short Polyelectrolyte Membrane Nanocoatings Aimed at Personal Protective and Medical Equipment Surfaces to Reduce Coronavirus Spreading
title_sort polyelectrolyte membrane nanocoatings aimed at personal protective and medical equipment surfaces to reduce coronavirus spreading
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611533/
https://www.ncbi.nlm.nih.gov/pubmed/36295705
http://dx.doi.org/10.3390/membranes12100946
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