Cargando…
Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women’s Health Research
The regulation of DHEA-sulfate by steroid sulfotransferase (SULT) and steryl-sulfatase (STS) enzymes is a vital process for the downstream formation of many steroid hormones. DHEA-sulfate is the most abundant steroid hormone in the human body; thus, DHEA-sulfate and its hydrolyzed form, DHEA, contin...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611561/ https://www.ncbi.nlm.nih.gov/pubmed/36295844 http://dx.doi.org/10.3390/metabo12100941 |
_version_ | 1784819557478694912 |
---|---|
author | Hamidovic, Ajna Soumare, Fatimata Naveed, Aamina Davis, John Sun, Jiehuan Dang, Nhan |
author_facet | Hamidovic, Ajna Soumare, Fatimata Naveed, Aamina Davis, John Sun, Jiehuan Dang, Nhan |
author_sort | Hamidovic, Ajna |
collection | PubMed |
description | The regulation of DHEA-sulfate by steroid sulfotransferase (SULT) and steryl-sulfatase (STS) enzymes is a vital process for the downstream formation of many steroid hormones. DHEA-sulfate is the most abundant steroid hormone in the human body; thus, DHEA-sulfate and its hydrolyzed form, DHEA, continue to be evaluated in numerous studies, given their importance to human health. Yet, a basic question of relevance to the reproductive-age female population—whether the two steroid hormones vary across the menstrual cycle—has not been addressed. We applied a validated, multi-step protocol, involving realignment and imputation of study data to early follicular, mid-late follicular, periovulatory, and early, mid-, and late luteal subphases of the menstrual cycle, and analyzed DHEA-sulfate and DHEA serum concentrations using ultraperformance liquid chromatography tandem mass spectrometry. DHEA-sulfate levels started to decrease in the early luteal, significantly dropped in the mid-luteal, and returned to basal levels by the late luteal subphase. DHEA, however, did not vary across the menstrual cycle. The present study deep-mapped trajectories of DHEA and DHEA-sulfate across the entire menstrual cycle, demonstrating a significant decrease in DHEA-sulfate in the mid-luteal subphase. These findings are relevant to the active area of research examining associations between DHEA-sulfate levels and various disease states. |
format | Online Article Text |
id | pubmed-9611561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96115612022-10-28 Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women’s Health Research Hamidovic, Ajna Soumare, Fatimata Naveed, Aamina Davis, John Sun, Jiehuan Dang, Nhan Metabolites Article The regulation of DHEA-sulfate by steroid sulfotransferase (SULT) and steryl-sulfatase (STS) enzymes is a vital process for the downstream formation of many steroid hormones. DHEA-sulfate is the most abundant steroid hormone in the human body; thus, DHEA-sulfate and its hydrolyzed form, DHEA, continue to be evaluated in numerous studies, given their importance to human health. Yet, a basic question of relevance to the reproductive-age female population—whether the two steroid hormones vary across the menstrual cycle—has not been addressed. We applied a validated, multi-step protocol, involving realignment and imputation of study data to early follicular, mid-late follicular, periovulatory, and early, mid-, and late luteal subphases of the menstrual cycle, and analyzed DHEA-sulfate and DHEA serum concentrations using ultraperformance liquid chromatography tandem mass spectrometry. DHEA-sulfate levels started to decrease in the early luteal, significantly dropped in the mid-luteal, and returned to basal levels by the late luteal subphase. DHEA, however, did not vary across the menstrual cycle. The present study deep-mapped trajectories of DHEA and DHEA-sulfate across the entire menstrual cycle, demonstrating a significant decrease in DHEA-sulfate in the mid-luteal subphase. These findings are relevant to the active area of research examining associations between DHEA-sulfate levels and various disease states. MDPI 2022-10-04 /pmc/articles/PMC9611561/ /pubmed/36295844 http://dx.doi.org/10.3390/metabo12100941 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hamidovic, Ajna Soumare, Fatimata Naveed, Aamina Davis, John Sun, Jiehuan Dang, Nhan Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women’s Health Research |
title | Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women’s Health Research |
title_full | Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women’s Health Research |
title_fullStr | Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women’s Health Research |
title_full_unstemmed | Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women’s Health Research |
title_short | Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women’s Health Research |
title_sort | reduced dehydroepiandrosterone-sulfate levels in the mid-luteal subphase of the menstrual cycle: implications to women’s health research |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611561/ https://www.ncbi.nlm.nih.gov/pubmed/36295844 http://dx.doi.org/10.3390/metabo12100941 |
work_keys_str_mv | AT hamidovicajna reduceddehydroepiandrosteronesulfatelevelsinthemidlutealsubphaseofthemenstrualcycleimplicationstowomenshealthresearch AT soumarefatimata reduceddehydroepiandrosteronesulfatelevelsinthemidlutealsubphaseofthemenstrualcycleimplicationstowomenshealthresearch AT naveedaamina reduceddehydroepiandrosteronesulfatelevelsinthemidlutealsubphaseofthemenstrualcycleimplicationstowomenshealthresearch AT davisjohn reduceddehydroepiandrosteronesulfatelevelsinthemidlutealsubphaseofthemenstrualcycleimplicationstowomenshealthresearch AT sunjiehuan reduceddehydroepiandrosteronesulfatelevelsinthemidlutealsubphaseofthemenstrualcycleimplicationstowomenshealthresearch AT dangnhan reduceddehydroepiandrosteronesulfatelevelsinthemidlutealsubphaseofthemenstrualcycleimplicationstowomenshealthresearch |