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Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil

Background: The correct understanding of the epidemiological dynamics of COVID-19, caused by the SARS-CoV-2, is essential for formulating public policies of disease containment. Methods: In this study, we constructed a picture of the epidemiological dynamics of COVID-19 in a Brazilian population of...

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Autores principales: Pinheiro, Josilene R., dos Reis, Esther C., Farias, Jéssica P., Fogaça, Mayanna M. C., da Silva, Patrícia de S., Santana, Itana Vivian R., Rocha, Ana Luiza S., Vidal, Paloma O., Simões, Rafael da C., Luiz, Wilson B., Birbrair, Alexander, de Aguiar, Renato S., de Souza, Renan P., Azevedo, Vasco A. de C., Chaves, Gepoliano, Belmok, Aline, Durães-Carvalho, Ricardo, Melo, Fernando L., Ribeiro, Bergmann M., Amorim, Jaime Henrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611628/
https://www.ncbi.nlm.nih.gov/pubmed/36298869
http://dx.doi.org/10.3390/v14102314
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author Pinheiro, Josilene R.
dos Reis, Esther C.
Farias, Jéssica P.
Fogaça, Mayanna M. C.
da Silva, Patrícia de S.
Santana, Itana Vivian R.
Rocha, Ana Luiza S.
Vidal, Paloma O.
Simões, Rafael da C.
Luiz, Wilson B.
Birbrair, Alexander
de Aguiar, Renato S.
de Souza, Renan P.
Azevedo, Vasco A. de C.
Chaves, Gepoliano
Belmok, Aline
Durães-Carvalho, Ricardo
Melo, Fernando L.
Ribeiro, Bergmann M.
Amorim, Jaime Henrique
author_facet Pinheiro, Josilene R.
dos Reis, Esther C.
Farias, Jéssica P.
Fogaça, Mayanna M. C.
da Silva, Patrícia de S.
Santana, Itana Vivian R.
Rocha, Ana Luiza S.
Vidal, Paloma O.
Simões, Rafael da C.
Luiz, Wilson B.
Birbrair, Alexander
de Aguiar, Renato S.
de Souza, Renan P.
Azevedo, Vasco A. de C.
Chaves, Gepoliano
Belmok, Aline
Durães-Carvalho, Ricardo
Melo, Fernando L.
Ribeiro, Bergmann M.
Amorim, Jaime Henrique
author_sort Pinheiro, Josilene R.
collection PubMed
description Background: The correct understanding of the epidemiological dynamics of COVID-19, caused by the SARS-CoV-2, is essential for formulating public policies of disease containment. Methods: In this study, we constructed a picture of the epidemiological dynamics of COVID-19 in a Brazilian population of almost 17000 patients in 15 months. We specifically studied the fluctuations of COVID-19 cases and deaths due to COVID-19 over time according to host gender, age, viral load, and genetic variants. Results: As the main results, we observed that the numbers of COVID-19 cases and deaths due to COVID-19 fluctuated over time and that men were the most affected by deaths, as well as those of 60 or more years old. We also observed that individuals between 30- and 44-years old were the most affected by COVID-19 cases. In addition, the viral loads in the patients’ nasopharynx were higher in the early symptomatic period. We found that early pandemic SARS-CoV-2 lineages were replaced by the variant of concern (VOC) P.1 (Gamma) in the second half of the study period, which led to a significant increase in the number of deaths. Conclusions: The results presented in this study are helpful for future formulations of efficient public policies of COVID-19 containment.
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spelling pubmed-96116282022-10-28 Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil Pinheiro, Josilene R. dos Reis, Esther C. Farias, Jéssica P. Fogaça, Mayanna M. C. da Silva, Patrícia de S. Santana, Itana Vivian R. Rocha, Ana Luiza S. Vidal, Paloma O. Simões, Rafael da C. Luiz, Wilson B. Birbrair, Alexander de Aguiar, Renato S. de Souza, Renan P. Azevedo, Vasco A. de C. Chaves, Gepoliano Belmok, Aline Durães-Carvalho, Ricardo Melo, Fernando L. Ribeiro, Bergmann M. Amorim, Jaime Henrique Viruses Article Background: The correct understanding of the epidemiological dynamics of COVID-19, caused by the SARS-CoV-2, is essential for formulating public policies of disease containment. Methods: In this study, we constructed a picture of the epidemiological dynamics of COVID-19 in a Brazilian population of almost 17000 patients in 15 months. We specifically studied the fluctuations of COVID-19 cases and deaths due to COVID-19 over time according to host gender, age, viral load, and genetic variants. Results: As the main results, we observed that the numbers of COVID-19 cases and deaths due to COVID-19 fluctuated over time and that men were the most affected by deaths, as well as those of 60 or more years old. We also observed that individuals between 30- and 44-years old were the most affected by COVID-19 cases. In addition, the viral loads in the patients’ nasopharynx were higher in the early symptomatic period. We found that early pandemic SARS-CoV-2 lineages were replaced by the variant of concern (VOC) P.1 (Gamma) in the second half of the study period, which led to a significant increase in the number of deaths. Conclusions: The results presented in this study are helpful for future formulations of efficient public policies of COVID-19 containment. MDPI 2022-10-21 /pmc/articles/PMC9611628/ /pubmed/36298869 http://dx.doi.org/10.3390/v14102314 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pinheiro, Josilene R.
dos Reis, Esther C.
Farias, Jéssica P.
Fogaça, Mayanna M. C.
da Silva, Patrícia de S.
Santana, Itana Vivian R.
Rocha, Ana Luiza S.
Vidal, Paloma O.
Simões, Rafael da C.
Luiz, Wilson B.
Birbrair, Alexander
de Aguiar, Renato S.
de Souza, Renan P.
Azevedo, Vasco A. de C.
Chaves, Gepoliano
Belmok, Aline
Durães-Carvalho, Ricardo
Melo, Fernando L.
Ribeiro, Bergmann M.
Amorim, Jaime Henrique
Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil
title Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil
title_full Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil
title_fullStr Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil
title_full_unstemmed Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil
title_short Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil
title_sort impact of early pandemic sars-cov-2 lineages replacement with the variant of concern p.1 (gamma) in western bahia, brazil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611628/
https://www.ncbi.nlm.nih.gov/pubmed/36298869
http://dx.doi.org/10.3390/v14102314
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