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Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil
Background: The correct understanding of the epidemiological dynamics of COVID-19, caused by the SARS-CoV-2, is essential for formulating public policies of disease containment. Methods: In this study, we constructed a picture of the epidemiological dynamics of COVID-19 in a Brazilian population of...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611628/ https://www.ncbi.nlm.nih.gov/pubmed/36298869 http://dx.doi.org/10.3390/v14102314 |
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author | Pinheiro, Josilene R. dos Reis, Esther C. Farias, Jéssica P. Fogaça, Mayanna M. C. da Silva, Patrícia de S. Santana, Itana Vivian R. Rocha, Ana Luiza S. Vidal, Paloma O. Simões, Rafael da C. Luiz, Wilson B. Birbrair, Alexander de Aguiar, Renato S. de Souza, Renan P. Azevedo, Vasco A. de C. Chaves, Gepoliano Belmok, Aline Durães-Carvalho, Ricardo Melo, Fernando L. Ribeiro, Bergmann M. Amorim, Jaime Henrique |
author_facet | Pinheiro, Josilene R. dos Reis, Esther C. Farias, Jéssica P. Fogaça, Mayanna M. C. da Silva, Patrícia de S. Santana, Itana Vivian R. Rocha, Ana Luiza S. Vidal, Paloma O. Simões, Rafael da C. Luiz, Wilson B. Birbrair, Alexander de Aguiar, Renato S. de Souza, Renan P. Azevedo, Vasco A. de C. Chaves, Gepoliano Belmok, Aline Durães-Carvalho, Ricardo Melo, Fernando L. Ribeiro, Bergmann M. Amorim, Jaime Henrique |
author_sort | Pinheiro, Josilene R. |
collection | PubMed |
description | Background: The correct understanding of the epidemiological dynamics of COVID-19, caused by the SARS-CoV-2, is essential for formulating public policies of disease containment. Methods: In this study, we constructed a picture of the epidemiological dynamics of COVID-19 in a Brazilian population of almost 17000 patients in 15 months. We specifically studied the fluctuations of COVID-19 cases and deaths due to COVID-19 over time according to host gender, age, viral load, and genetic variants. Results: As the main results, we observed that the numbers of COVID-19 cases and deaths due to COVID-19 fluctuated over time and that men were the most affected by deaths, as well as those of 60 or more years old. We also observed that individuals between 30- and 44-years old were the most affected by COVID-19 cases. In addition, the viral loads in the patients’ nasopharynx were higher in the early symptomatic period. We found that early pandemic SARS-CoV-2 lineages were replaced by the variant of concern (VOC) P.1 (Gamma) in the second half of the study period, which led to a significant increase in the number of deaths. Conclusions: The results presented in this study are helpful for future formulations of efficient public policies of COVID-19 containment. |
format | Online Article Text |
id | pubmed-9611628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96116282022-10-28 Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil Pinheiro, Josilene R. dos Reis, Esther C. Farias, Jéssica P. Fogaça, Mayanna M. C. da Silva, Patrícia de S. Santana, Itana Vivian R. Rocha, Ana Luiza S. Vidal, Paloma O. Simões, Rafael da C. Luiz, Wilson B. Birbrair, Alexander de Aguiar, Renato S. de Souza, Renan P. Azevedo, Vasco A. de C. Chaves, Gepoliano Belmok, Aline Durães-Carvalho, Ricardo Melo, Fernando L. Ribeiro, Bergmann M. Amorim, Jaime Henrique Viruses Article Background: The correct understanding of the epidemiological dynamics of COVID-19, caused by the SARS-CoV-2, is essential for formulating public policies of disease containment. Methods: In this study, we constructed a picture of the epidemiological dynamics of COVID-19 in a Brazilian population of almost 17000 patients in 15 months. We specifically studied the fluctuations of COVID-19 cases and deaths due to COVID-19 over time according to host gender, age, viral load, and genetic variants. Results: As the main results, we observed that the numbers of COVID-19 cases and deaths due to COVID-19 fluctuated over time and that men were the most affected by deaths, as well as those of 60 or more years old. We also observed that individuals between 30- and 44-years old were the most affected by COVID-19 cases. In addition, the viral loads in the patients’ nasopharynx were higher in the early symptomatic period. We found that early pandemic SARS-CoV-2 lineages were replaced by the variant of concern (VOC) P.1 (Gamma) in the second half of the study period, which led to a significant increase in the number of deaths. Conclusions: The results presented in this study are helpful for future formulations of efficient public policies of COVID-19 containment. MDPI 2022-10-21 /pmc/articles/PMC9611628/ /pubmed/36298869 http://dx.doi.org/10.3390/v14102314 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pinheiro, Josilene R. dos Reis, Esther C. Farias, Jéssica P. Fogaça, Mayanna M. C. da Silva, Patrícia de S. Santana, Itana Vivian R. Rocha, Ana Luiza S. Vidal, Paloma O. Simões, Rafael da C. Luiz, Wilson B. Birbrair, Alexander de Aguiar, Renato S. de Souza, Renan P. Azevedo, Vasco A. de C. Chaves, Gepoliano Belmok, Aline Durães-Carvalho, Ricardo Melo, Fernando L. Ribeiro, Bergmann M. Amorim, Jaime Henrique Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil |
title | Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil |
title_full | Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil |
title_fullStr | Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil |
title_full_unstemmed | Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil |
title_short | Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil |
title_sort | impact of early pandemic sars-cov-2 lineages replacement with the variant of concern p.1 (gamma) in western bahia, brazil |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611628/ https://www.ncbi.nlm.nih.gov/pubmed/36298869 http://dx.doi.org/10.3390/v14102314 |
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