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Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors

The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of three endoplasmic reticulum (ER) transmembrane sensors of the unfolded protein response (UPR) responsible for regulating protein synthesis and alleviating ER stress. PERK has been implicated in tumorigenesis, cancer cell s...

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Detalles Bibliográficos
Autores principales:	Stokes, Michael E., Surman, Matthew D., Calvo, Veronica, Surguladze, David, Li, An-Hu, Gasparek, Jennifer, Betzenhauser, Matthew, Zhu, Guangyu, Du, Hongwen, Rigby, Alan C., Mulvihill, Mark J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611727/ https://www.ncbi.nlm.nih.gov/pubmed/36297668 http://dx.doi.org/10.3390/pharmaceutics14102233

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