Toward Optimized (89)Zr-Immuno-PET: Side-by-Side Comparison of [(89)Zr]Zr-DFO-, [(89)Zr]Zr-3,4,3-(LI-1,2-HOPO)- and [(89)Zr]Zr-DFO*-Cetuximab for Tumor Imaging: Which Chelator Is the Most Suitable?

(89)Zr represents a highly favorable positron emitter for application in immuno-PET (Positron Emission Tomography) imaging. Clinically, the (89)Zr(4+) ion is introduced into antibodies by complexation with desferrioxamine B. However, producing complexes of limited kinetic inertness. Therefore, sever...

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Detalles Bibliográficos
Autores principales: Damerow, Helen, Cheng, Xia, von Kiedrowski, Valeska, Schirrmacher, Ralf, Wängler, Björn, Fricker, Gert, Wängler, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611803/
https://www.ncbi.nlm.nih.gov/pubmed/36297549
http://dx.doi.org/10.3390/pharmaceutics14102114

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