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Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents

Type 2 diabetes mellitus (T2DM) is the most common endocrine disorder (90%) in the world; it has numerous clinical, immunological, and genetic differences from type 1 diabetes mellitus. The pathogenesis of T2DM is complex and not fully clear. To date, animal models remain the main tool by which to s...

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Autores principales: Gvazava, I. G., Karimova, M. V., Vasiliev, A. V., Vorotelyak, E. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611859/
https://www.ncbi.nlm.nih.gov/pubmed/36348712
http://dx.doi.org/10.32607/actanaturae.11751
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author Gvazava, I. G.
Karimova, M. V.
Vasiliev, A. V.
Vorotelyak, E. A.
author_facet Gvazava, I. G.
Karimova, M. V.
Vasiliev, A. V.
Vorotelyak, E. A.
author_sort Gvazava, I. G.
collection PubMed
description Type 2 diabetes mellitus (T2DM) is the most common endocrine disorder (90%) in the world; it has numerous clinical, immunological, and genetic differences from type 1 diabetes mellitus. The pathogenesis of T2DM is complex and not fully clear. To date, animal models remain the main tool by which to study the pathophysiology and therapy of T2DM. Rodents are considered the best choice among animal models, because they are characterized by a small size, short induction period, easy diabetes induction, and economic efficiency. This review summarizes data on experimental models of T2DM that are currently used, evaluates their advantages and disadvantages vis-a-vis research, and describes in detail the factors that should be taken into account when using these models. Selection of a suitable model for tackling a particular issue is not always trivial; it affects study results and their interpretation.
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spelling pubmed-96118592022-11-07 Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents Gvazava, I. G. Karimova, M. V. Vasiliev, A. V. Vorotelyak, E. A. Acta Naturae Research Article Type 2 diabetes mellitus (T2DM) is the most common endocrine disorder (90%) in the world; it has numerous clinical, immunological, and genetic differences from type 1 diabetes mellitus. The pathogenesis of T2DM is complex and not fully clear. To date, animal models remain the main tool by which to study the pathophysiology and therapy of T2DM. Rodents are considered the best choice among animal models, because they are characterized by a small size, short induction period, easy diabetes induction, and economic efficiency. This review summarizes data on experimental models of T2DM that are currently used, evaluates their advantages and disadvantages vis-a-vis research, and describes in detail the factors that should be taken into account when using these models. Selection of a suitable model for tackling a particular issue is not always trivial; it affects study results and their interpretation. A.I. Gordeyev 2022 /pmc/articles/PMC9611859/ /pubmed/36348712 http://dx.doi.org/10.32607/actanaturae.11751 Text en Copyright ® 2022 National Research University Higher School of Economics. https://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gvazava, I. G.
Karimova, M. V.
Vasiliev, A. V.
Vorotelyak, E. A.
Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents
title Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents
title_full Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents
title_fullStr Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents
title_full_unstemmed Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents
title_short Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents
title_sort type 2 diabetes mellitus: pathogenic features and experimental models in rodents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611859/
https://www.ncbi.nlm.nih.gov/pubmed/36348712
http://dx.doi.org/10.32607/actanaturae.11751
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