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Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents
Type 2 diabetes mellitus (T2DM) is the most common endocrine disorder (90%) in the world; it has numerous clinical, immunological, and genetic differences from type 1 diabetes mellitus. The pathogenesis of T2DM is complex and not fully clear. To date, animal models remain the main tool by which to s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
A.I. Gordeyev
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611859/ https://www.ncbi.nlm.nih.gov/pubmed/36348712 http://dx.doi.org/10.32607/actanaturae.11751 |
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author | Gvazava, I. G. Karimova, M. V. Vasiliev, A. V. Vorotelyak, E. A. |
author_facet | Gvazava, I. G. Karimova, M. V. Vasiliev, A. V. Vorotelyak, E. A. |
author_sort | Gvazava, I. G. |
collection | PubMed |
description | Type 2 diabetes mellitus (T2DM) is the most common endocrine disorder (90%) in the world; it has numerous clinical, immunological, and genetic differences from type 1 diabetes mellitus. The pathogenesis of T2DM is complex and not fully clear. To date, animal models remain the main tool by which to study the pathophysiology and therapy of T2DM. Rodents are considered the best choice among animal models, because they are characterized by a small size, short induction period, easy diabetes induction, and economic efficiency. This review summarizes data on experimental models of T2DM that are currently used, evaluates their advantages and disadvantages vis-a-vis research, and describes in detail the factors that should be taken into account when using these models. Selection of a suitable model for tackling a particular issue is not always trivial; it affects study results and their interpretation. |
format | Online Article Text |
id | pubmed-9611859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | A.I. Gordeyev |
record_format | MEDLINE/PubMed |
spelling | pubmed-96118592022-11-07 Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents Gvazava, I. G. Karimova, M. V. Vasiliev, A. V. Vorotelyak, E. A. Acta Naturae Research Article Type 2 diabetes mellitus (T2DM) is the most common endocrine disorder (90%) in the world; it has numerous clinical, immunological, and genetic differences from type 1 diabetes mellitus. The pathogenesis of T2DM is complex and not fully clear. To date, animal models remain the main tool by which to study the pathophysiology and therapy of T2DM. Rodents are considered the best choice among animal models, because they are characterized by a small size, short induction period, easy diabetes induction, and economic efficiency. This review summarizes data on experimental models of T2DM that are currently used, evaluates their advantages and disadvantages vis-a-vis research, and describes in detail the factors that should be taken into account when using these models. Selection of a suitable model for tackling a particular issue is not always trivial; it affects study results and their interpretation. A.I. Gordeyev 2022 /pmc/articles/PMC9611859/ /pubmed/36348712 http://dx.doi.org/10.32607/actanaturae.11751 Text en Copyright ® 2022 National Research University Higher School of Economics. https://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gvazava, I. G. Karimova, M. V. Vasiliev, A. V. Vorotelyak, E. A. Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents |
title | Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents |
title_full | Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents |
title_fullStr | Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents |
title_full_unstemmed | Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents |
title_short | Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents |
title_sort | type 2 diabetes mellitus: pathogenic features and experimental models in rodents |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611859/ https://www.ncbi.nlm.nih.gov/pubmed/36348712 http://dx.doi.org/10.32607/actanaturae.11751 |
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