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Tight Junctions, the Key Factor in Virus-Related Disease

Tight junctions (TJs) are highly specialized membrane structural domains that hold cells together and form a continuous intercellular barrier in epithelial cells. TJs regulate paracellular permeability and participate in various cellular signaling pathways. As physical barriers, TJs can block viral...

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Detalles Bibliográficos
Autores principales: Ding, Guofei, Shao, Qingyuan, Yu, Haiyan, Liu, Jiaqi, Li, Yingchao, Wang, Bin, Sang, Haotian, Li, Dexin, Bing, Aiying, Hou, Yanmeng, Xiao, Yihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611889/
https://www.ncbi.nlm.nih.gov/pubmed/36297257
http://dx.doi.org/10.3390/pathogens11101200
Descripción
Sumario:Tight junctions (TJs) are highly specialized membrane structural domains that hold cells together and form a continuous intercellular barrier in epithelial cells. TJs regulate paracellular permeability and participate in various cellular signaling pathways. As physical barriers, TJs can block viral entry into host cells; however, viruses use a variety of strategies to circumvent this barrier to facilitate their infection. This paper summarizes how viruses evade various barriers during infection by regulating the expression of TJs to facilitate their own entry into the organism causing infection, which will help to develop drugs targeting TJs to contain virus-related disease.