An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study

Cytochrome P450 2D6 (CYP2D6) gene polymorphisms influence the exposure to tramadol (T) and its pharmacologically active metabolite, O-demethyl tramadol (O-dT). Tramadol has been considered as a candidate probe drug for CYP2D6 phenotyping. The objective of the CYTRAM study was to investigate the valu...

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Detalles Bibliográficos
Autores principales: De La Gastine, Blandine, Percevault, Soizic, Varin, Laurent, Richard, Nicolas, Fobe, Fabienne, Plaud, Benoît, Daccache, Georges, Compere, Vincent, Parienti, Jean-Jacques, Coquerel, Antoine, Loilier, Magalie, Bleyzac, Nathalie, Bourguignon, Laurent, Goutelle, Sylvain, Lelong-Boulouard, Véronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611900/
https://www.ncbi.nlm.nih.gov/pubmed/36297612
http://dx.doi.org/10.3390/pharmaceutics14102177

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