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Structural Aspects and Intermolecular Energy for Some Short Testosterone Esters

Testosterone (17β-hydroxyandrost-4-en-3-one) is the primary naturally occurring anabolic–androgenic steroid. The crystal structures of three short esterified forms of testosterone, including propionate, phenylpropionate, and isocaproate ester, were determined via single-crystal X-ray diffraction. Fu...

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Autores principales: Turza, Alexandru, Popescu, Violeta, Mare, Liviu, Borodi, Gheorghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611952/
https://www.ncbi.nlm.nih.gov/pubmed/36295310
http://dx.doi.org/10.3390/ma15207245
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author Turza, Alexandru
Popescu, Violeta
Mare, Liviu
Borodi, Gheorghe
author_facet Turza, Alexandru
Popescu, Violeta
Mare, Liviu
Borodi, Gheorghe
author_sort Turza, Alexandru
collection PubMed
description Testosterone (17β-hydroxyandrost-4-en-3-one) is the primary naturally occurring anabolic–androgenic steroid. The crystal structures of three short esterified forms of testosterone, including propionate, phenylpropionate, and isocaproate ester, were determined via single-crystal X-ray diffraction. Furthermore, all the samples were investigated using powder X-ray diffraction, and their structural features were described and evaluated in terms of crystal energies and Hirshfeld surfaces. They were also compared with the base form of testosterone (without ester) and the acetate ester. Moreover, from a pharmaceutical perspective, their solubility was evaluated and correlated with the length of the ester.
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spelling pubmed-96119522022-10-28 Structural Aspects and Intermolecular Energy for Some Short Testosterone Esters Turza, Alexandru Popescu, Violeta Mare, Liviu Borodi, Gheorghe Materials (Basel) Article Testosterone (17β-hydroxyandrost-4-en-3-one) is the primary naturally occurring anabolic–androgenic steroid. The crystal structures of three short esterified forms of testosterone, including propionate, phenylpropionate, and isocaproate ester, were determined via single-crystal X-ray diffraction. Furthermore, all the samples were investigated using powder X-ray diffraction, and their structural features were described and evaluated in terms of crystal energies and Hirshfeld surfaces. They were also compared with the base form of testosterone (without ester) and the acetate ester. Moreover, from a pharmaceutical perspective, their solubility was evaluated and correlated with the length of the ester. MDPI 2022-10-17 /pmc/articles/PMC9611952/ /pubmed/36295310 http://dx.doi.org/10.3390/ma15207245 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Turza, Alexandru
Popescu, Violeta
Mare, Liviu
Borodi, Gheorghe
Structural Aspects and Intermolecular Energy for Some Short Testosterone Esters
title Structural Aspects and Intermolecular Energy for Some Short Testosterone Esters
title_full Structural Aspects and Intermolecular Energy for Some Short Testosterone Esters
title_fullStr Structural Aspects and Intermolecular Energy for Some Short Testosterone Esters
title_full_unstemmed Structural Aspects and Intermolecular Energy for Some Short Testosterone Esters
title_short Structural Aspects and Intermolecular Energy for Some Short Testosterone Esters
title_sort structural aspects and intermolecular energy for some short testosterone esters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611952/
https://www.ncbi.nlm.nih.gov/pubmed/36295310
http://dx.doi.org/10.3390/ma15207245
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