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Neotropical Sylvatic Mosquitoes and Aedes aegypti Are Not Competent to Transmit 17DD Attenuated Yellow Fever Virus from Vaccinated Viremic New World Non-Human Primates

Beside humans, thousands of non-human primates (NHPs) died during the recent outbreak caused by the yellow fever virus (YFV) in Brazil. Vaccination of NHPs against YFV with the YF 17DD attenuated virus has emerged as a public health strategy, as it would reduce sylvatic transmission while also prese...

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Autores principales: de Miranda, Rafaella Moraes, Fernandes, Rosilainy Surubi, da Silva-Fernandes, André Tavares, Ferreira-de-Brito, Anielly, Moreira, Silvia Bahadian, Pereira, Renata Carvalho, da Silva Mendes, Ygara, de Lima, Sheila Maria Barbosa, Pissinatti, Alcides, Freire, Marcos da Silva, Alencar, Jerônimo Augusto Fonseca, Lourenco-de-Oliveira, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611963/
https://www.ncbi.nlm.nih.gov/pubmed/36298786
http://dx.doi.org/10.3390/v14102231
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author de Miranda, Rafaella Moraes
Fernandes, Rosilainy Surubi
da Silva-Fernandes, André Tavares
Ferreira-de-Brito, Anielly
Moreira, Silvia Bahadian
Pereira, Renata Carvalho
da Silva Mendes, Ygara
de Lima, Sheila Maria Barbosa
Pissinatti, Alcides
Freire, Marcos da Silva
Alencar, Jerônimo Augusto Fonseca
Lourenco-de-Oliveira, Ricardo
author_facet de Miranda, Rafaella Moraes
Fernandes, Rosilainy Surubi
da Silva-Fernandes, André Tavares
Ferreira-de-Brito, Anielly
Moreira, Silvia Bahadian
Pereira, Renata Carvalho
da Silva Mendes, Ygara
de Lima, Sheila Maria Barbosa
Pissinatti, Alcides
Freire, Marcos da Silva
Alencar, Jerônimo Augusto Fonseca
Lourenco-de-Oliveira, Ricardo
author_sort de Miranda, Rafaella Moraes
collection PubMed
description Beside humans, thousands of non-human primates (NHPs) died during the recent outbreak caused by the yellow fever virus (YFV) in Brazil. Vaccination of NHPs against YFV with the YF 17DD attenuated virus has emerged as a public health strategy, as it would reduce sylvatic transmission while also preserving endangered susceptible species. The hypothesis of establishing an uncontrolled transmission of this attenuated virus in nature was raised. We assessed vector competence of four sylvatic mosquito species, Haemagogus leucocelaenus, Haemagogus janthinomys/capricornii, Sabethes albiprivus, and Sabethes identicus, as well as the urban vector Aedes aegypti for YF 17DD attenuated vaccine virus when fed directly on eleven viremic lion tamarins or artificially challenged with the same virus. No infection was detected in 689 mosquitoes engorged on viremic lion tamarins whose viremia ranged from 1.05 × 10(3) to 6.61 × 10(3) FFU/mL, nor in those artificially taking ≤ 1 × 10(3) PFU/mL. Low viremia presented by YF 17DD-vaccinated New World NHPs combined with the low capacity and null dissemination ability in sylvatic and domestic mosquitoes of this attenuated virus suggest no risk of its transmission in nature. Thus, vaccination of captive and free-living NHPs against YFV is a safe public health strategy.
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spelling pubmed-96119632022-10-28 Neotropical Sylvatic Mosquitoes and Aedes aegypti Are Not Competent to Transmit 17DD Attenuated Yellow Fever Virus from Vaccinated Viremic New World Non-Human Primates de Miranda, Rafaella Moraes Fernandes, Rosilainy Surubi da Silva-Fernandes, André Tavares Ferreira-de-Brito, Anielly Moreira, Silvia Bahadian Pereira, Renata Carvalho da Silva Mendes, Ygara de Lima, Sheila Maria Barbosa Pissinatti, Alcides Freire, Marcos da Silva Alencar, Jerônimo Augusto Fonseca Lourenco-de-Oliveira, Ricardo Viruses Article Beside humans, thousands of non-human primates (NHPs) died during the recent outbreak caused by the yellow fever virus (YFV) in Brazil. Vaccination of NHPs against YFV with the YF 17DD attenuated virus has emerged as a public health strategy, as it would reduce sylvatic transmission while also preserving endangered susceptible species. The hypothesis of establishing an uncontrolled transmission of this attenuated virus in nature was raised. We assessed vector competence of four sylvatic mosquito species, Haemagogus leucocelaenus, Haemagogus janthinomys/capricornii, Sabethes albiprivus, and Sabethes identicus, as well as the urban vector Aedes aegypti for YF 17DD attenuated vaccine virus when fed directly on eleven viremic lion tamarins or artificially challenged with the same virus. No infection was detected in 689 mosquitoes engorged on viremic lion tamarins whose viremia ranged from 1.05 × 10(3) to 6.61 × 10(3) FFU/mL, nor in those artificially taking ≤ 1 × 10(3) PFU/mL. Low viremia presented by YF 17DD-vaccinated New World NHPs combined with the low capacity and null dissemination ability in sylvatic and domestic mosquitoes of this attenuated virus suggest no risk of its transmission in nature. Thus, vaccination of captive and free-living NHPs against YFV is a safe public health strategy. MDPI 2022-10-11 /pmc/articles/PMC9611963/ /pubmed/36298786 http://dx.doi.org/10.3390/v14102231 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Miranda, Rafaella Moraes
Fernandes, Rosilainy Surubi
da Silva-Fernandes, André Tavares
Ferreira-de-Brito, Anielly
Moreira, Silvia Bahadian
Pereira, Renata Carvalho
da Silva Mendes, Ygara
de Lima, Sheila Maria Barbosa
Pissinatti, Alcides
Freire, Marcos da Silva
Alencar, Jerônimo Augusto Fonseca
Lourenco-de-Oliveira, Ricardo
Neotropical Sylvatic Mosquitoes and Aedes aegypti Are Not Competent to Transmit 17DD Attenuated Yellow Fever Virus from Vaccinated Viremic New World Non-Human Primates
title Neotropical Sylvatic Mosquitoes and Aedes aegypti Are Not Competent to Transmit 17DD Attenuated Yellow Fever Virus from Vaccinated Viremic New World Non-Human Primates
title_full Neotropical Sylvatic Mosquitoes and Aedes aegypti Are Not Competent to Transmit 17DD Attenuated Yellow Fever Virus from Vaccinated Viremic New World Non-Human Primates
title_fullStr Neotropical Sylvatic Mosquitoes and Aedes aegypti Are Not Competent to Transmit 17DD Attenuated Yellow Fever Virus from Vaccinated Viremic New World Non-Human Primates
title_full_unstemmed Neotropical Sylvatic Mosquitoes and Aedes aegypti Are Not Competent to Transmit 17DD Attenuated Yellow Fever Virus from Vaccinated Viremic New World Non-Human Primates
title_short Neotropical Sylvatic Mosquitoes and Aedes aegypti Are Not Competent to Transmit 17DD Attenuated Yellow Fever Virus from Vaccinated Viremic New World Non-Human Primates
title_sort neotropical sylvatic mosquitoes and aedes aegypti are not competent to transmit 17dd attenuated yellow fever virus from vaccinated viremic new world non-human primates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611963/
https://www.ncbi.nlm.nih.gov/pubmed/36298786
http://dx.doi.org/10.3390/v14102231
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