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Clinical Potential of Himalayan Herb Bergenia ligulata: An Evidence-Based Study

Herbal products have been used in traditional systems of medicine and by ethnic healers for ages to treat various diseases. Currently, it is estimated that about 80% of people worldwide use herbal traditional medicines against various ailments, partly due to easy accessibility and low cost, and the...

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Autores principales: Roychoudhury, Shubhadeep, Das, Dipika, Das, Sandipan, Jha, Niraj Kumar, Pal, Mahadeb, Kolesarova, Adriana, Kesari, Kavindra Kumar, Kalita, Jogen C., Slama, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611975/
https://www.ncbi.nlm.nih.gov/pubmed/36296631
http://dx.doi.org/10.3390/molecules27207039
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author Roychoudhury, Shubhadeep
Das, Dipika
Das, Sandipan
Jha, Niraj Kumar
Pal, Mahadeb
Kolesarova, Adriana
Kesari, Kavindra Kumar
Kalita, Jogen C.
Slama, Petr
author_facet Roychoudhury, Shubhadeep
Das, Dipika
Das, Sandipan
Jha, Niraj Kumar
Pal, Mahadeb
Kolesarova, Adriana
Kesari, Kavindra Kumar
Kalita, Jogen C.
Slama, Petr
author_sort Roychoudhury, Shubhadeep
collection PubMed
description Herbal products have been used in traditional systems of medicine and by ethnic healers for ages to treat various diseases. Currently, it is estimated that about 80% of people worldwide use herbal traditional medicines against various ailments, partly due to easy accessibility and low cost, and the lower side effects they pose. Bergenia ligulata, a herb ranging from the Himalayas to the foothills, including the north-eastern states of India, has traditionally been used as a remedy against various diseases, most prominently kidney stones. The medicinal properties of B. ligulata have been attributed to bergenin, its most potent bioactive component. Apart from bergenin, the other compounds available in B. ligulata are arbutin, gallic acid, protocatechuic acid, chlorogenic acid, syringic acid, catechin, ferulic acid, afzelechin, paashaanolactone, caryophyllene, 1,8-cineole, β-eudesmol, stigmasterol, β-sitosterol, parasorbic acid, 3-methyl-2-buten-1-ol, phytol, terpinen-4-ol, tannic acid, isovalaric acid, avicularin, quercetin, reynoutrin, and sitoinoside I. This review summarizes various medicinal properties of the herb, along with providing deep insight into its bioactive molecules and their potential roles in the amelioration of human ailments. Additionally, the possible mechanism(s) of action of the herb’s anti-urolithiatic, antioxidative, antipyretic, anti-diabetic, anti-inflammatory and hepatoprotective properties are discussed. This comprehensive documentation will help researchers to better understand the medicinal uses of the herb. Further studies on B. ligulata can lead to the discovery of new drug(s) and therapeutics for various ailments.
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spelling pubmed-96119752022-10-28 Clinical Potential of Himalayan Herb Bergenia ligulata: An Evidence-Based Study Roychoudhury, Shubhadeep Das, Dipika Das, Sandipan Jha, Niraj Kumar Pal, Mahadeb Kolesarova, Adriana Kesari, Kavindra Kumar Kalita, Jogen C. Slama, Petr Molecules Review Herbal products have been used in traditional systems of medicine and by ethnic healers for ages to treat various diseases. Currently, it is estimated that about 80% of people worldwide use herbal traditional medicines against various ailments, partly due to easy accessibility and low cost, and the lower side effects they pose. Bergenia ligulata, a herb ranging from the Himalayas to the foothills, including the north-eastern states of India, has traditionally been used as a remedy against various diseases, most prominently kidney stones. The medicinal properties of B. ligulata have been attributed to bergenin, its most potent bioactive component. Apart from bergenin, the other compounds available in B. ligulata are arbutin, gallic acid, protocatechuic acid, chlorogenic acid, syringic acid, catechin, ferulic acid, afzelechin, paashaanolactone, caryophyllene, 1,8-cineole, β-eudesmol, stigmasterol, β-sitosterol, parasorbic acid, 3-methyl-2-buten-1-ol, phytol, terpinen-4-ol, tannic acid, isovalaric acid, avicularin, quercetin, reynoutrin, and sitoinoside I. This review summarizes various medicinal properties of the herb, along with providing deep insight into its bioactive molecules and their potential roles in the amelioration of human ailments. Additionally, the possible mechanism(s) of action of the herb’s anti-urolithiatic, antioxidative, antipyretic, anti-diabetic, anti-inflammatory and hepatoprotective properties are discussed. This comprehensive documentation will help researchers to better understand the medicinal uses of the herb. Further studies on B. ligulata can lead to the discovery of new drug(s) and therapeutics for various ailments. MDPI 2022-10-18 /pmc/articles/PMC9611975/ /pubmed/36296631 http://dx.doi.org/10.3390/molecules27207039 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Roychoudhury, Shubhadeep
Das, Dipika
Das, Sandipan
Jha, Niraj Kumar
Pal, Mahadeb
Kolesarova, Adriana
Kesari, Kavindra Kumar
Kalita, Jogen C.
Slama, Petr
Clinical Potential of Himalayan Herb Bergenia ligulata: An Evidence-Based Study
title Clinical Potential of Himalayan Herb Bergenia ligulata: An Evidence-Based Study
title_full Clinical Potential of Himalayan Herb Bergenia ligulata: An Evidence-Based Study
title_fullStr Clinical Potential of Himalayan Herb Bergenia ligulata: An Evidence-Based Study
title_full_unstemmed Clinical Potential of Himalayan Herb Bergenia ligulata: An Evidence-Based Study
title_short Clinical Potential of Himalayan Herb Bergenia ligulata: An Evidence-Based Study
title_sort clinical potential of himalayan herb bergenia ligulata: an evidence-based study
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9611975/
https://www.ncbi.nlm.nih.gov/pubmed/36296631
http://dx.doi.org/10.3390/molecules27207039
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