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cGMP Analogues with Opposing Actions on CNG Channels Selectively Modulate Rod or Cone Photoreceptor Function

The vertebrate retina harbors rod and cone photoreceptors. Human vision critically depends on cone photoreceptor function. In the phototransduction cascade, cGMP activates distinct rod and cone isoforms of the cyclic nucleotide-gated (CNG) channel. Excessive cGMP levels initiate a pathophysiological...

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Detalles Bibliográficos
Autores principales:	Wucherpfennig, Sophie, Haq, Wadood, Popp, Valerie, Kesh, Sandeep, Das, Soumyaparna, Melle, Christian, Rentsch, Andreas, Schwede, Frank, Paquet-Durand, François, Nache, Vasilica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612005/ https://www.ncbi.nlm.nih.gov/pubmed/36297537 http://dx.doi.org/10.3390/pharmaceutics14102102

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