Cargando…
Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina
Background: Quadrivalent cell-based influenza vaccines (QIVc) avoid egg-adaptive mutations and can be more effective than traditional quadrivalent egg-based influenza vaccines (QIVe). This analysis compared the cost-effectiveness of QIVc and QIVe in Argentinian populations < 65 years old from the...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612026/ https://www.ncbi.nlm.nih.gov/pubmed/36298493 http://dx.doi.org/10.3390/vaccines10101627 |
_version_ | 1784819674920255488 |
---|---|
author | Urueña, Analía Micone, Paula Magneres, María Cecilia McGovern, Ian Mould-Quevedo, Joaquin Sarmento, Túlio Tadeu Rocha Giglio, Norberto |
author_facet | Urueña, Analía Micone, Paula Magneres, María Cecilia McGovern, Ian Mould-Quevedo, Joaquin Sarmento, Túlio Tadeu Rocha Giglio, Norberto |
author_sort | Urueña, Analía |
collection | PubMed |
description | Background: Quadrivalent cell-based influenza vaccines (QIVc) avoid egg-adaptive mutations and can be more effective than traditional quadrivalent egg-based influenza vaccines (QIVe). This analysis compared the cost-effectiveness of QIVc and QIVe in Argentinian populations < 65 years old from the payer and societal perspectives. Methods: A static decision tree model compared the costs and health benefits of vaccination with QIVc vs. QIVe using a one-year time horizon. The relative vaccine effectiveness of QIVc vs. QIVe was assumed to be 8.1% for children and 11.4% for adults. An alternative high egg-adaptation scenario was also assessed. Model inputs were sourced from Argentina or the international literature. Deterministic and probabilistic sensitivity analyses were performed. Results: Compared to QIVe, QIVc would prevent 17,857 general practitioner visits, 2418 complications, 816 hospitalizations, and 12 deaths per year. From the payers’ perspective, the incremental cost-effectiveness ratio per quality-adjusted life years gained was USD12,214 in the base case and USD2311 in the high egg-adaptation scenario. QIVc was cost-saving from the societal perspective in both scenarios. Conclusions: QIVc in Argentina would be cost-effective relative to QIVe. The potential health benefits and savings would be even higher in high egg-adaptation seasons. |
format | Online Article Text |
id | pubmed-9612026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96120262022-10-28 Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina Urueña, Analía Micone, Paula Magneres, María Cecilia McGovern, Ian Mould-Quevedo, Joaquin Sarmento, Túlio Tadeu Rocha Giglio, Norberto Vaccines (Basel) Article Background: Quadrivalent cell-based influenza vaccines (QIVc) avoid egg-adaptive mutations and can be more effective than traditional quadrivalent egg-based influenza vaccines (QIVe). This analysis compared the cost-effectiveness of QIVc and QIVe in Argentinian populations < 65 years old from the payer and societal perspectives. Methods: A static decision tree model compared the costs and health benefits of vaccination with QIVc vs. QIVe using a one-year time horizon. The relative vaccine effectiveness of QIVc vs. QIVe was assumed to be 8.1% for children and 11.4% for adults. An alternative high egg-adaptation scenario was also assessed. Model inputs were sourced from Argentina or the international literature. Deterministic and probabilistic sensitivity analyses were performed. Results: Compared to QIVe, QIVc would prevent 17,857 general practitioner visits, 2418 complications, 816 hospitalizations, and 12 deaths per year. From the payers’ perspective, the incremental cost-effectiveness ratio per quality-adjusted life years gained was USD12,214 in the base case and USD2311 in the high egg-adaptation scenario. QIVc was cost-saving from the societal perspective in both scenarios. Conclusions: QIVc in Argentina would be cost-effective relative to QIVe. The potential health benefits and savings would be even higher in high egg-adaptation seasons. MDPI 2022-09-28 /pmc/articles/PMC9612026/ /pubmed/36298493 http://dx.doi.org/10.3390/vaccines10101627 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Urueña, Analía Micone, Paula Magneres, María Cecilia McGovern, Ian Mould-Quevedo, Joaquin Sarmento, Túlio Tadeu Rocha Giglio, Norberto Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina |
title | Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina |
title_full | Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina |
title_fullStr | Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina |
title_full_unstemmed | Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina |
title_short | Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina |
title_sort | cost-effectiveness analysis of cell versus egg-based seasonal influenza vaccination in children and adults in argentina |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612026/ https://www.ncbi.nlm.nih.gov/pubmed/36298493 http://dx.doi.org/10.3390/vaccines10101627 |
work_keys_str_mv | AT uruenaanalia costeffectivenessanalysisofcellversuseggbasedseasonalinfluenzavaccinationinchildrenandadultsinargentina AT miconepaula costeffectivenessanalysisofcellversuseggbasedseasonalinfluenzavaccinationinchildrenandadultsinargentina AT magneresmariacecilia costeffectivenessanalysisofcellversuseggbasedseasonalinfluenzavaccinationinchildrenandadultsinargentina AT mcgovernian costeffectivenessanalysisofcellversuseggbasedseasonalinfluenzavaccinationinchildrenandadultsinargentina AT mouldquevedojoaquin costeffectivenessanalysisofcellversuseggbasedseasonalinfluenzavaccinationinchildrenandadultsinargentina AT sarmentotuliotadeurocha costeffectivenessanalysisofcellversuseggbasedseasonalinfluenzavaccinationinchildrenandadultsinargentina AT giglionorberto costeffectivenessanalysisofcellversuseggbasedseasonalinfluenzavaccinationinchildrenandadultsinargentina |