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Development of a Silicone-Based Polymer Matrix as a Suitable Transdermal Therapeutic System for Diallyl Disulfide

There is an unmet need for novel therapeutic tools relieving chronic pain. Hydrogen sulfide (H(2)S) is highly involved in pain processes; however, the development of ideal matrices for sulfide donor compounds remains a great pharmaceutical challenge. We aimed to establish a suitable transdermal ther...

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Autores principales: László, Szabolcs, Hajna, Zsófia, Egyed, Attila, Pintér, Erika, Wagner, Ödön
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612217/
https://www.ncbi.nlm.nih.gov/pubmed/36297294
http://dx.doi.org/10.3390/ph15101182
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author László, Szabolcs
Hajna, Zsófia
Egyed, Attila
Pintér, Erika
Wagner, Ödön
author_facet László, Szabolcs
Hajna, Zsófia
Egyed, Attila
Pintér, Erika
Wagner, Ödön
author_sort László, Szabolcs
collection PubMed
description There is an unmet need for novel therapeutic tools relieving chronic pain. Hydrogen sulfide (H(2)S) is highly involved in pain processes; however, the development of ideal matrices for sulfide donor compounds remains a great pharmaceutical challenge. We aimed to establish a suitable transdermal therapeutic system (TTS) using the H(2)S donor diallyl disulfide (DADS) as a model compound. After the preparation of DADS, its solubility was investigated in different liquid excipients (propylene glycol, polyethylene glycol, silicone oil) and its membrane diffusivity was assessed in silicone matrices of different compositions. Drug-releasing properties of DADS-containing patches with different silicone oil contents were determined with Franz and flow-through cells. We found a correlation between the liquid excipient content of the patch and the diffusion rate of DADS. DADS showed the best solubility in dimethyl silicone oil, and the diffusion constant was proportional to the amount of oil above the 3 m/m% threshold value. The 8-day-old patch showed a significantly lower, but better-regulated, drug release over time than the 4-day-old one. In conclusion, the silicone-based polymer matrix developed in this study is suitable for stable storage and optimal release of DADS, providing a good basis for a TTS applied in chronic pain.
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spelling pubmed-96122172022-10-28 Development of a Silicone-Based Polymer Matrix as a Suitable Transdermal Therapeutic System for Diallyl Disulfide László, Szabolcs Hajna, Zsófia Egyed, Attila Pintér, Erika Wagner, Ödön Pharmaceuticals (Basel) Article There is an unmet need for novel therapeutic tools relieving chronic pain. Hydrogen sulfide (H(2)S) is highly involved in pain processes; however, the development of ideal matrices for sulfide donor compounds remains a great pharmaceutical challenge. We aimed to establish a suitable transdermal therapeutic system (TTS) using the H(2)S donor diallyl disulfide (DADS) as a model compound. After the preparation of DADS, its solubility was investigated in different liquid excipients (propylene glycol, polyethylene glycol, silicone oil) and its membrane diffusivity was assessed in silicone matrices of different compositions. Drug-releasing properties of DADS-containing patches with different silicone oil contents were determined with Franz and flow-through cells. We found a correlation between the liquid excipient content of the patch and the diffusion rate of DADS. DADS showed the best solubility in dimethyl silicone oil, and the diffusion constant was proportional to the amount of oil above the 3 m/m% threshold value. The 8-day-old patch showed a significantly lower, but better-regulated, drug release over time than the 4-day-old one. In conclusion, the silicone-based polymer matrix developed in this study is suitable for stable storage and optimal release of DADS, providing a good basis for a TTS applied in chronic pain. MDPI 2022-09-23 /pmc/articles/PMC9612217/ /pubmed/36297294 http://dx.doi.org/10.3390/ph15101182 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
László, Szabolcs
Hajna, Zsófia
Egyed, Attila
Pintér, Erika
Wagner, Ödön
Development of a Silicone-Based Polymer Matrix as a Suitable Transdermal Therapeutic System for Diallyl Disulfide
title Development of a Silicone-Based Polymer Matrix as a Suitable Transdermal Therapeutic System for Diallyl Disulfide
title_full Development of a Silicone-Based Polymer Matrix as a Suitable Transdermal Therapeutic System for Diallyl Disulfide
title_fullStr Development of a Silicone-Based Polymer Matrix as a Suitable Transdermal Therapeutic System for Diallyl Disulfide
title_full_unstemmed Development of a Silicone-Based Polymer Matrix as a Suitable Transdermal Therapeutic System for Diallyl Disulfide
title_short Development of a Silicone-Based Polymer Matrix as a Suitable Transdermal Therapeutic System for Diallyl Disulfide
title_sort development of a silicone-based polymer matrix as a suitable transdermal therapeutic system for diallyl disulfide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612217/
https://www.ncbi.nlm.nih.gov/pubmed/36297294
http://dx.doi.org/10.3390/ph15101182
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