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Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of Myrtus communis against Staphylococcus Species

Myrtaceae family is a continuous source of antimicrobial agents. In the search for novel antimicrobial agents against Staphylococcus species, bioactive fractions of Myrtus communis L., growing in the Sardinia island (Italy) have been investigated. Their phytochemical analysis led us to isolate and c...

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Autores principales: Guzzo, Francesca, Durán, Alexandra G., Sanna, Cinzia, Marasco, Rosangela, Molfetta, Nicola, Buommino, Elisabetta, Fiorentino, Antonio, D’Abrosca, Brigida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612225/
https://www.ncbi.nlm.nih.gov/pubmed/36296701
http://dx.doi.org/10.3390/molecules27207109
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author Guzzo, Francesca
Durán, Alexandra G.
Sanna, Cinzia
Marasco, Rosangela
Molfetta, Nicola
Buommino, Elisabetta
Fiorentino, Antonio
D’Abrosca, Brigida
author_facet Guzzo, Francesca
Durán, Alexandra G.
Sanna, Cinzia
Marasco, Rosangela
Molfetta, Nicola
Buommino, Elisabetta
Fiorentino, Antonio
D’Abrosca, Brigida
author_sort Guzzo, Francesca
collection PubMed
description Myrtaceae family is a continuous source of antimicrobial agents. In the search for novel antimicrobial agents against Staphylococcus species, bioactive fractions of Myrtus communis L., growing in the Sardinia island (Italy) have been investigated. Their phytochemical analysis led us to isolate and characterize four alkylphloroglucinol glycosides (1–4), three of them gallomyrtucommulones G–H (1,2), and myrtucommulonoside (4) isolated and characterized for the first time. The structures of the new and known compounds, endopreroxide G3 (5), myricetin-3-O-glycosides (6,7) were determined based on the spectroscopic evidence including 1D-/2D-NMR and HR-MS spectrometry. Enriched fractions as well as pure compounds were tested for their antimicrobial activity by broth micro-dilution assay against Staphylococcus epidermidis and S. aureus. Results reported herein demonstrated that gallomyrtucommulone G (1) showed a selective antimicrobial activity against both S. aureus strains (ATCC 29213 and 43300) until 16 μg/mL while gallomyrtucommulone D (3) showed the best growth inhibition value at 64 μg/mL.
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spelling pubmed-96122252022-10-28 Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of Myrtus communis against Staphylococcus Species Guzzo, Francesca Durán, Alexandra G. Sanna, Cinzia Marasco, Rosangela Molfetta, Nicola Buommino, Elisabetta Fiorentino, Antonio D’Abrosca, Brigida Molecules Article Myrtaceae family is a continuous source of antimicrobial agents. In the search for novel antimicrobial agents against Staphylococcus species, bioactive fractions of Myrtus communis L., growing in the Sardinia island (Italy) have been investigated. Their phytochemical analysis led us to isolate and characterize four alkylphloroglucinol glycosides (1–4), three of them gallomyrtucommulones G–H (1,2), and myrtucommulonoside (4) isolated and characterized for the first time. The structures of the new and known compounds, endopreroxide G3 (5), myricetin-3-O-glycosides (6,7) were determined based on the spectroscopic evidence including 1D-/2D-NMR and HR-MS spectrometry. Enriched fractions as well as pure compounds were tested for their antimicrobial activity by broth micro-dilution assay against Staphylococcus epidermidis and S. aureus. Results reported herein demonstrated that gallomyrtucommulone G (1) showed a selective antimicrobial activity against both S. aureus strains (ATCC 29213 and 43300) until 16 μg/mL while gallomyrtucommulone D (3) showed the best growth inhibition value at 64 μg/mL. MDPI 2022-10-21 /pmc/articles/PMC9612225/ /pubmed/36296701 http://dx.doi.org/10.3390/molecules27207109 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guzzo, Francesca
Durán, Alexandra G.
Sanna, Cinzia
Marasco, Rosangela
Molfetta, Nicola
Buommino, Elisabetta
Fiorentino, Antonio
D’Abrosca, Brigida
Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of Myrtus communis against Staphylococcus Species
title Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of Myrtus communis against Staphylococcus Species
title_full Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of Myrtus communis against Staphylococcus Species
title_fullStr Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of Myrtus communis against Staphylococcus Species
title_full_unstemmed Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of Myrtus communis against Staphylococcus Species
title_short Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of Myrtus communis against Staphylococcus Species
title_sort gallomyrtucommulones g and h, new phloroglucinol glycosides, from bioactive fractions of myrtus communis against staphylococcus species
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612225/
https://www.ncbi.nlm.nih.gov/pubmed/36296701
http://dx.doi.org/10.3390/molecules27207109
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