Cargando…

Transforming Growth Factor-β Concerning Malarial Infection and Severity: A Systematic Review and Meta-Analysis

Transforming growth factor-β (TGF-β) is important in the pathophysiology of malaria, but its role in acute and severe malaria is largely unknown. As a result, this study used a meta-analysis approach to investigate the difference in TGF-β levels between several groups of malaria patients and healthy...

Descripción completa

Detalles Bibliográficos
Autores principales: Kotepui, Kwuntida Uthaisar, Kwankaew, Pattamaporn, Masangkay, Frederick Ramirez, Mahittikorn, Aongart, Kotepui, Manas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612234/
https://www.ncbi.nlm.nih.gov/pubmed/36288040
http://dx.doi.org/10.3390/tropicalmed7100299
_version_ 1784819724110004224
author Kotepui, Kwuntida Uthaisar
Kwankaew, Pattamaporn
Masangkay, Frederick Ramirez
Mahittikorn, Aongart
Kotepui, Manas
author_facet Kotepui, Kwuntida Uthaisar
Kwankaew, Pattamaporn
Masangkay, Frederick Ramirez
Mahittikorn, Aongart
Kotepui, Manas
author_sort Kotepui, Kwuntida Uthaisar
collection PubMed
description Transforming growth factor-β (TGF-β) is important in the pathophysiology of malaria, but its role in acute and severe malaria is largely unknown. As a result, this study used a meta-analysis approach to investigate the difference in TGF-β levels between several groups of malaria patients and healthy controls. The systematic review protocol was registered at PROSPERO (ID: CRD42022318864). From inception to 7 March 2022, studies that reported TGF-β levels in patients with uncomplicated and healthy controls and patients with severe and uncomplicated malaria were searched in PubMed, Scopus and Embase. The assessment of the quality of the included studies was conducted according to the Strengthening the Reporting of Observational Studies in Epidemiology guidelines. Qualitative and quantitative syntheses were performed to narratively describe and quantitatively pool the mean difference (MD) in TGF-β levels between uncomplicated malaria and healthy controls, and between severe and uncomplicated malaria, using a random-effects model. A total of 1027 relevant articles were identified, and 13 studies were included for syntheses. The meta-analysis results show 233 patients with uncomplicated malaria and 239 healthy controls. Patients with uncomplicated malaria (233 cases) had lower mean TGF-β levels than healthy controls (239 cases; p < 0.01, pooled MD = −14.72 pg/mL, 95% confidence interval (95% CI) = −20.46 to 8.99 pg/mL, I(2) = 98.82%, seven studies). The meta-analysis found no difference in mean TGF-β levels between patients with severe malaria (367 cases) and patients with uncomplicated malaria (180 cases; p = 0.11, pooled MD = −6.07 pg/mL, 95% CI = −13.48 to 1.35 pg/mL, I(2) = 97.73%, six studies). The meta-analysis demonstrated decreased TGF-β levels in patients with uncomplicated malaria compared to healthy controls. In addition, no difference in TGF-β levels was found between patients with severe and uncomplicated malaria. More research is needed to determine whether TGF-β levels could be a candidate marker for malarial infection or disease severity.
format Online
Article
Text
id pubmed-9612234
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96122342022-10-28 Transforming Growth Factor-β Concerning Malarial Infection and Severity: A Systematic Review and Meta-Analysis Kotepui, Kwuntida Uthaisar Kwankaew, Pattamaporn Masangkay, Frederick Ramirez Mahittikorn, Aongart Kotepui, Manas Trop Med Infect Dis Systematic Review Transforming growth factor-β (TGF-β) is important in the pathophysiology of malaria, but its role in acute and severe malaria is largely unknown. As a result, this study used a meta-analysis approach to investigate the difference in TGF-β levels between several groups of malaria patients and healthy controls. The systematic review protocol was registered at PROSPERO (ID: CRD42022318864). From inception to 7 March 2022, studies that reported TGF-β levels in patients with uncomplicated and healthy controls and patients with severe and uncomplicated malaria were searched in PubMed, Scopus and Embase. The assessment of the quality of the included studies was conducted according to the Strengthening the Reporting of Observational Studies in Epidemiology guidelines. Qualitative and quantitative syntheses were performed to narratively describe and quantitatively pool the mean difference (MD) in TGF-β levels between uncomplicated malaria and healthy controls, and between severe and uncomplicated malaria, using a random-effects model. A total of 1027 relevant articles were identified, and 13 studies were included for syntheses. The meta-analysis results show 233 patients with uncomplicated malaria and 239 healthy controls. Patients with uncomplicated malaria (233 cases) had lower mean TGF-β levels than healthy controls (239 cases; p < 0.01, pooled MD = −14.72 pg/mL, 95% confidence interval (95% CI) = −20.46 to 8.99 pg/mL, I(2) = 98.82%, seven studies). The meta-analysis found no difference in mean TGF-β levels between patients with severe malaria (367 cases) and patients with uncomplicated malaria (180 cases; p = 0.11, pooled MD = −6.07 pg/mL, 95% CI = −13.48 to 1.35 pg/mL, I(2) = 97.73%, six studies). The meta-analysis demonstrated decreased TGF-β levels in patients with uncomplicated malaria compared to healthy controls. In addition, no difference in TGF-β levels was found between patients with severe and uncomplicated malaria. More research is needed to determine whether TGF-β levels could be a candidate marker for malarial infection or disease severity. MDPI 2022-10-13 /pmc/articles/PMC9612234/ /pubmed/36288040 http://dx.doi.org/10.3390/tropicalmed7100299 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Kotepui, Kwuntida Uthaisar
Kwankaew, Pattamaporn
Masangkay, Frederick Ramirez
Mahittikorn, Aongart
Kotepui, Manas
Transforming Growth Factor-β Concerning Malarial Infection and Severity: A Systematic Review and Meta-Analysis
title Transforming Growth Factor-β Concerning Malarial Infection and Severity: A Systematic Review and Meta-Analysis
title_full Transforming Growth Factor-β Concerning Malarial Infection and Severity: A Systematic Review and Meta-Analysis
title_fullStr Transforming Growth Factor-β Concerning Malarial Infection and Severity: A Systematic Review and Meta-Analysis
title_full_unstemmed Transforming Growth Factor-β Concerning Malarial Infection and Severity: A Systematic Review and Meta-Analysis
title_short Transforming Growth Factor-β Concerning Malarial Infection and Severity: A Systematic Review and Meta-Analysis
title_sort transforming growth factor-β concerning malarial infection and severity: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612234/
https://www.ncbi.nlm.nih.gov/pubmed/36288040
http://dx.doi.org/10.3390/tropicalmed7100299
work_keys_str_mv AT kotepuikwuntidauthaisar transforminggrowthfactorbconcerningmalarialinfectionandseverityasystematicreviewandmetaanalysis
AT kwankaewpattamaporn transforminggrowthfactorbconcerningmalarialinfectionandseverityasystematicreviewandmetaanalysis
AT masangkayfrederickramirez transforminggrowthfactorbconcerningmalarialinfectionandseverityasystematicreviewandmetaanalysis
AT mahittikornaongart transforminggrowthfactorbconcerningmalarialinfectionandseverityasystematicreviewandmetaanalysis
AT kotepuimanas transforminggrowthfactorbconcerningmalarialinfectionandseverityasystematicreviewandmetaanalysis